Лиотон Drug photo

The description is actual on 11.03.2015

  • Latin name: Lioton 1000
  • ATH code: C05BA03
  • Active ingredient: Heparin sodium (Heparinum natricum)
  • Producer: Berlin-Chemie AG Menarini Group (Germany)


Heparin sodium in concentration of 1000 ME/gram is Lioton's part as active agent.

As auxiliary components are a part of gel: methyl - and propyl-p-hydroxybenzoate, oils of not role and a lavender, carbomer 940, trietanolamine, ethanol, the purified water.

Release form

Dosage form of drug — gel for external use. Means represents almost transparent, colourless or slightly yellowish, viscous weight.

Gel Lioton 1000 goes on sale in aluminum tubas of 30, 50 or 100 grams.

Pharmacological action

Antitrombotichesky, antiekssuadtivny, moderate antiinflammatory.

Pharmacodynamics and pharmacokinetics

When drawing on skin Lioton gel removes puffiness, eliminates a hyperpermeability of vascular walls and interferes with an exit of liquid (exudate) in adjacent fabrics, stops inflammatory process, activity of coagulant system of blood oppresses (has anticoagulating anticoagulative effect).

After drug use heparin is found in a blood plasma for the next 24 hours, at the same time plasma concentration reaches the maximum values in 8 hours.

Excretion of substance and its metabolites is carried out mainly by kidneys. When drawing heparin does not exert impact on hemocoagulation parameters on skin.

Indications to use

Ointment Lioton 1000 is recommended to apply at diseases of the superficial veins including complicated by a phlebothrombosis (a state which is connected with education in a gleam of a vein of the blood clot fixed to its wall, partially or completely occlusive a vessel), thrombophlebitis (thrombosis which is followed by an inflammation of a vascular wall and overlapping of a gleam of a vessel blood clot) or a superficial periphlebitis (an acute or chronic inflammation of a wall of a vein).

Ointment use Lioton for elimination of the complications provoked by a surgery on veins, effects of injuries and stretchings of capsular and copular and muscular and tendinous devices, damages of soft tissues and a musculoskeletal system is considered expedient.

Means effectively removes the localized hypostasis of fabrics, eliminates inflammatory infiltrate, accelerates a rassasyvaniye of hypodermic hematomas.


It is not necessary to use cream Lioton 1000 at:

  • the known individual sensitivity to its components;
  • existence of ulcer and necrotic changes of an integument on sites of expected drawing means;
  • traumatic disturbances of integrity of an integument;
  • the lowered hemocoagulation;
  • thrombocytopenia.

Side effects

Allergic reactions.

Gel Lioton, application instruction

In the application instruction of Lioton it is specified that the single dose for the adult corresponds to the gel volume which is contained in a strip from 3 to 10 cm long (depending on extensiveness of defeat). After drawing on skin ointment should be rubbed carefully the easy movements.

Frequency rate of uses — from 1 to 3 times a day.

According to the instruction on Lioton 1000, duration of treatment depends on indications and severity of pathological process.


There are no messages on cases of overdose so far. As system absorption of heparin sodium is extremely insignificant, danger of overdose by means at topical administration is absent.

At an accidental proglatyvaniye of gel at the child nausea and vomiting can be noted. For assistance to the victim it is necessary to wash out a stomach and if in it there is a need, to appoint a symptomatic treatment.

Antidote is protamin sulfate.


Use of heparin in a combination with anticoagulants for oral administration can provoke lengthening of a prothrombin time.

It is not necessary to mix Lioton with other drugs for external use.

It is contraindicated to appoint means in a combination with NPVP, antibiotics of a tetracycline row, antihistaminic drugs.

Terms of sale

Without recipe.

Storage conditions

Gel is recommended to be stored at a temperature no more than 25 degrees Celsius in the place, unavailable to children.

Period of validity

Means is considered suitable for use during 5 flyings after a date of issue.

Special instructions

As auxiliary components are a part of gel methyl - and propyl-p-hydroxybenzoate therefore Lioton is contraindicated to persons with the known allergy to parabens.

At patients with hemorrhagic symptoms it is necessary to weigh expediency of use of means carefully.

Drug cannot be used at bleedings and defeats of an integument purulent process, to apply on the infected sites of skin and open wounds, mucous membranes, skin sites around eyes. It is also necessary to avoid hit of gel in eyes.

Patients with disturbances of hemocoagulation are not recommended to process drug extensive sites of an integument. At treatment of phlebitis, it is contraindicated to rub ointment in skin.

As experience of use of Lioton for children is limited, it is not necessary to appoint drug for treatment of the specified category of patients.

Means does not exert impact on ability to steer vehicles and does not slow down mental and motor activity.

Analogs Lioton 1000

Coincidence on the ATH code of the 4th level:

Structural analogs of gel Lioton 1000 (generics) are drugs Geparin-Akrigel 1000, Laventum, Trombless, Heparin.

To group of the drugs close on the action mechanism, belong: To Venitan Forta, Venolayf, Unguentum Heparini, Geparoid Zentiva, Gepatrombin, Dolobene, Kontraktubeks, Venabos, Trombless Plus, Troxevasinum Neo.

Russian analogs of Lioton: Heparin, Geparin-Akrigel, Unguentum Heparini.

The price of analogs — from 35 Russian rubles (purchase of a tube of Unguentum Heparini of 25 g of production of the Russian company JSC Biosintez will cost approximately 35-60 rubles).

Lioton or Unguentum Heparini?

Gel and its analog Unguentum Heparini are direct anticoagulants. The main mechanism of their antitrombotichesky action is connected with thrombin suppression.

The sodium salt of heparin which is active component of Lioton as a part of Unguentum Heparini is present at smaller concentration — 100 ME/gram (in Liotona its concentration in one gram of means 1000 ME). However in addition to heparin sodium also contain in Unguentum Heparini benzocaine (local anesthetic of a broad spectrum of activity) and an antiagregant benzilnikotinat.

Estimating efficiency of both means, patients note that the effect of their use is expressed approximately equally therefore for many at the drug choice the price — Unguentum Heparini much cheaper the analog becomes a decisive factor.


  • Lioton of 1000 100 g gela.menarini Manufacturing Logistics
  • Lioton of 1000 30 g gela.menarini Manufacturing Logistics
  • Lioton of 1000 50 g gela.menarini Manufacturing Logistics

Drugstore of IFC

  • Lioton 1000 gel 30 of, Berlin-Chemie/Menarini Groupitaliya
  • Lioton 1000 gel 100 of, Berlin-Chemie/Menarini Groupitaliya
  • Lioton 1000 gel 50 of, Berlin-Chemie/Menarini Groupitaliya
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  • Lioton 1000Menarirni Manufacturing (Italy)
  • Lioton gel of a 30gberlin-Hema (Germany)


  • Lioton 30gberlin-Hema gel
  • Lioton 30gberlin-Hema gel


  • Lioton of 1000 100 g gel naruzhn. A. Menarini Menyufekchering Lodzhistiks and Servisiz of Neuter. L. for Astellas of Farm of INK., Japan (Italy)
  • Lioton of 100000 ED/100 g 50 g gel naruzhn. (Stock 2+1) A. Menarini (Italy)
  • Lioton of 100000 ED/100 g 50 g gel naruzhn.a. Menarini (Italy)
  • Lioton of 100000 ED/100 g 30 g gel naruzhn.a. Menarini (Italy)
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Section: Cardiovascular
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