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In 1 bottle of interferon of alpha 2b 500 000 ME. Sodium chloride, vitamin C, vitamin E, sodium hydrophosphate, sodium digidrofosfatadigidrat, cholesterol, lecithin, lactose as excipients.
The lyophilized powder for preparation of suspension on 500000 ME in bottles.
Pharmacodynamics and pharmacokinetics
The liposomal drug having active substances: recombinant interferon alpha 2b, ascorbic acid and vitamin E. The liposomal covering — from lecithin and cholesterol — is the carrier of medicinal substances. The active agents included in liposomes are steadier in an organism, do not collapse in a digestive tract therefore oral administration is possible, have low toxicity, do not cause allergic and immune responses. Active agent is released from a lipidic membrane by an exocytosis when liposomes merge with a cell wall. It provides delivery it directly in a cell.
Drug has antiviral effect. Recombinant interferon is emitted from colibacillus cells which genetic code included a gene of interferon alpha 2b the person. Biological activity of recombinant and human interferon are identical. It suppresses penetration of viruses into a cell. On a surface of a cell initiates a chain of changes which prevent replication of viruses in a cell. Immunomodulatory action is connected with increase of activity of macrophages, strengthening of action of T lymphocytes. Lipoferon is active concerning gram-positive microorganisms that is caused by strengthening of phagocytal activity and cytotoxicity of natural killers.
Reception of a liposomal form inside provides long circulation of interferon. Absorption happens in initial departments of a small intestine, a metabolism — in a liver. The elimination half-life makes 6 hours.
Indications to use
- complex treatment of hepatitis B;
- allergic rino-conjunctivitis;
- bronchial asthma (carrying out a specific immunotherapy);
- treatment of flu, SARS;
- chlamydial infection (as a part of complex therapy).
- hypersensitivity to interferon;
- serious allergic illness;
- age till 3 flyings;
- pregnancy and feeding by a breast.
Lipoferon, application instruction (Way and dosage)
Lipoferon of 500 thousand ME is applied inside. It is necessary to add 2 ml of boiled water to contents of a bottle, it is good to stir up before formation of homogeneous suspension.
Hepatitis B — in 30 min. prior to food on 1 million ME twice a day, 10 days and more before clinical recovery. To children from 3 to 7 years appoint 500 000 ME once a day.
Allergic rinokonjyunktivit — 500000 ME once a day.
Atopic OH — 500000 ME once a day, 10 days, then every other day in the same dose of 20 more days.
Prevention of a SARS — 500000 ME 2 time a week to accept 1 month. In case of treatment of a SARS — 500000 ME 2 time a day, every day, 3-5 days. To store ready suspension in the refrigerator no more than 12 hours.
Cases are not revealed.
With care to appoint with antiepileptic drugs, antidepressants which clearance depends on the P450 system of tsitokhrom.
At chronic hepatitis it is impossible to appoint immunosuppressive drugs — they promote strengthening of replication of a virus.
Studying of interaction with corticosteroids it was not carried out. Perhaps joint appointment them at patients with multiple sclerosis at recurrence.
Terms of sale
It is released according to the recipe.
Temperature of storage is 8 °C.
Suspensions — 12 hours at a temperature of 8 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
Creation of artificial liposomes — the perspective direction of nanobiotechnology. Liposomal drugs prolong effect of the entered medicine and increase its bioavailability. LSP of various orientation are used: antineoplastic, antifungal, antioxidant, gepatoprotektorny and antiviral.
Lipoferon is the representative of liposomal drugs who has properties of recombinant interferon, but differs from them in high safety, the best portability, long presence of interferon at blood and an opportunity to call products of endogenous interferon. Also vitamins E are its part and With which strengthen antiviral action and minimize toxic influence of interferon on a children's organism therefore this drug is successfully used in pediatrics.
For prevention of ORZ at children drug on 250 000 ME once a day, only 2 times a week one month was used. With the medical purpose — on 250 000 ME 2 times a day within 3 days. Preventive appointment led to decrease in frequency of diseases twice. If drug was used at sick people, reduction of an intoksikatsionny syndrome (weakness, an ache, a headache), reduction of the period of fever and the general duration of an illness till 5 days is noticed. By results of laboratory researches — improvement of cellular and humoral immunity.
"… To us the doctor at a disease already the second time appoints to 3-5 days. The child is 3 years old. Really ORZ proceeds easier, does without bronchitis — and it is our scourge".
Lipoferon joined in the scheme of the combined treatment of a viral hepatitis With in a dose of 2 million ME every other day together with ribaviriny that also showed success of therapy. Patients had an effective purpose of this drug with a syndrome of chronic fatigue.
"… I have a viral hepatitis of S. Propisali Lipoferon's scheme of 2 million every other day, to drink 6 months. The effect was stunning — appetite improved, weakness and fast fatigue disappeared, the mood improved. Made tests on VHC RNA — much better".
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