Loperamide Hydrochloride

Лоперамида Гидрохлорид Drug photo

The description is actual on 16.09.2015

  • Latin name: Loperamide hydrochloride
  • ATH code: A07DA03
  • Active ingredient: Loperamide (Loperamide)
  • Producer: Fleming Laboratories, Vasudha Pharma Chem, Kempro of Farm of Pvt. Ltd. (India), LLC Harkovskoye pharmaceutical enterprise "Health to the People" (Ukraine)

Structure

1 capsule includes 2 mg of loperamide of a hydrochloride – active ingredient.

Additional components: milk sugar, corn starch, magnesium stearate.

Release form

The Health to the People company lets out Loperamide the Hydrochloride in the form of capsules, on 10 or 20 pieces in a pack.

Pharmacological action

Antidiarrheal.

Pharmacodynamics and pharmacokinetics

Loperamide the Hydrochloride is anti-diarrheal drug which efficiency consists in oppression of a vermicular movement of intestines. Effect of drug is shown thanks to linkng of its active ingredient with the opioid receptors which are in intestines walls owing to what there is a suppression of release of E2α prostaglandin and acetylcholine. As a result of such influence advance of contents of intestines and its peristaltics is slowed down, and also time of absorption of electrolytes and water lasts. In addition to it, medicine possesses anti-secretory action, reduces desires to defecation, increases a tone of a sphincter of an anus and promotes control of fecal masses.

Medicine T1/2 on average equals to 11 (from 9 to 14) to hours. Communication with plasma proteins (mainly with albumine) is at the level of 95%. The elimination is carried out thanks to the oxidizing N-demethylation which is the main way of metabolic transformations of drug. It is brought out of a human body mainly with a fecal masses.

Indications to use

Use of Loperamide of the Hydrochloride is shown for a symptomatic treatment of diarrhea chronic and acuity.

Use of drug for prevention at diarrhea of travelers is possible. In this case therapy has to continue, at least, 48 hours. Only at detection in Calais blood reception of HP should be interrupted, up to exact establishment of the reason of this phenomenon.

Contraindications

Appointment of drug is not allowed at:

  • the pathologies connected with intolerance of sugars;
  • personal hypersensitivity to loperamide to a hydrochloride or other components of tablets;
  • the pseudomembranous colitis or acute ulcer colitis which developed because of the previous antibioticotherapia;
  • acute dysentery (with manifestations of temperature increase and availability of blood in Calais);
  • bacterial coloenteritis, owing to influence of bacteria of families of Kampilobakter, Shigellas and Salmonellas;
  • liver pathologies;
  • to children till 6 years.

Side effects

Immune system:

Nervous system:

Alimentary system:

  • gripes/spasms in a stomach;
  • nausea/vomiting;
  • Ilheus;
  • lock;
  • the forced forming of toxic megacolon;
  • dyspepsia;
  • dryness in an oral cavity;
  • meteorism;
  • intestinal impassability (paralytic).

Urinary system:

Integuments:

Application instruction of Loperamide of the Hydrochloride

According to the instruction on Loperamide the Hydrochloride drug is intended for intake (orally), the patients who reached 6 summer age.

At acute diarrhea reception of an initial dose of 4 mg by adult patients and 2 mg by children is shown. In the subsequent, despite age of the patient, recommend to accept 2 mg of drug after each liquid defecation.

At chronic diarrhea appoint daily 4 mg to adult patients and on 2 mg to children. Further it is necessary to pick up individually a maintenance dose of drug for what loperamide the hydrochloride is dosed so that the number of acts of firm defecation in days made 1-2 times. At the same time the individual dosing mode varies in the range of 2-12 mg of 24 hours.

At any display of diarrhea (chronic/acute) the maximum daily dosage for adults the dose of 16 mg is considered. For children this dose is expected proceeding from their weight, in the ratio by 6 mg 20 kg of body weight.

In the absence of clinical performance of treatment of acute diarrhea for 48 hours, administration of drug should be cancelled.

For therapy of elderly patients and patients with pathologies of kidneys correction of the dosing mode is not required.

At liver pathologies prescription of medicine has to pass with care, in connection with possible delay of metabolic transformations of the first passing.

Drug is not appointed for initial therapy of heavy diarrhea which proceeds with decrease in level of electrolytes and liquids in an organism. At children's age such loss should be offset purpose of peroral and/or parenteral replacement therapy.

Overdose

At disturbance of the dosing mode and reception of the overestimated drug doses can be observed: stupor, drowsiness, lack of coordination, miosis, respiratory depression, hyper tone of muscles of a skeleton, ischuria, and also symptomatology of intestinal impassability. Children, because of the blood-brain barrier which is not functioning fully are most subject to impact of drug on TsNS.

Antidote of drug is Naloxonum. Because loperamide the hydrochloride works for 1-3 hours longer than Naloxonum, there can be a need for repeated use of an antidote. For detection of possible suppression of TsNS the patient is obliged to be under medical supervision for at least 48 hours. In parallel with use of an antidote it is possible to carry out the symptomatic treatment including cleaning of a gastrointestinal tract and reception of sorbents.

Interaction

The combined use with cholinolytic drugs (atropine) causes mutual increase in efficiency in this connection it is better to avoid a similar combination of HP.

You should not carry out loperamide therapy by a hydrochloride at use by the patient of the HP suppressing TsNS (in particular to children).

Parallel use of the drugs which are inhibitors of P-glycoproteins (Ritonavir, Quinidine) and dosages of loperamide of a hydrochloride of confidants to maximum, increases the plasma level of the last by 2-3 times. The importance of such interaction for clinical therapy, in the range of reception of doses of loperamide of a hydrochloride of 2-16 mg is not established.

Terms of sale

Loperamide the Hydrochloride comes to drugstores as an OTC medicine.

Storage conditions

It is necessary to adhere to temperature condition of storage of capsules of drug which makes – up to 25 °C.

Period of validity

From the moment of production – 3 years.

Special instructions

It is worth remembering that hydrochloride loperamide use for treatment of diarrhea has symptomatic character. In a case when the diarrhea origin is precisely diagnosed, it is better to carry out purposeful therapy with use of the drugs shown for this disease state.

Purely against diarrhea, in particular at children, the imbalance of electrolytes and dehydration forms. At supervision of these phenomena first of all it is necessary to hold the events directed to replenishment of electrolytes and liquid in an organism.

At hydrochloride loperamide reception for treatment of diarrhea at patients with an immunodeficiency syndrome, in case of detection of the first symptoms of abdominal distention, carrying out therapy is immediately stopped. Also at patients with AIDS noted the separate facts of forming of toxic megacolon with parallel infectious colitis of both a bacterial, and virus etiology.

Despite the lack of deviations in pharmacokinetic parameters of loperamide of a hydrochloride at treatment of patients with pathologies of the liver given to group of patients it is necessary to appoint drug with care, because of delay of metabolic transformations of the first passing. For timely detection of possible symptomatology of toxic defeat of TsNS such patients have to be under continuous supervision.

Because of presence at lactose drug, its reception is prohibited patients with intolerance of sugars.

In case of forming of abdominal distention, a lock, partial intestinal obstruction, and also the megacolon, a divertuculosis, a coloenteritis connected with influence of bacteria of a genus of salmonellas it is necessary to stop therapy immediately.

Analogs

Coincidence on the ATH code of the 4th level:

Apteka24

  • GIDROKHLORIDZDOROVYE LOPERAMIDE to the people (Ukraine, Kharkiv)
  • Loperamide hydrochloride of OZ of a tablet 2 of mg No. 20OZ GNTsLS (Ukraine, Kharkiv)

BIOSPHERE

  • Loperamide hydrochloride of 2 mg No. 10 kaps. Borisovsky ZMP (Belarus)
  • Loperamide hydrochloride of 2 mg No. 10 kaps. Health to the people of HGFP (Ukraine)
  • Loperamide hydrochloride of 0,002 g No. 20 of the tab. Lekhim-Kharkiv autonomous area (Ukraine)
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Section: Gastrointestinal
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Education: Graduated from the Vinnytsia national medical university of N. I. Pirogov, pharmaceutical faculty, the higher pharmaceutical education – the specialty "Pharmacist".

Experience: Work in Koneks and Bios-Media pharmacy chains as "Druggist". Work as "Pharmacist" in Avicenna pharmacy chain of the city of Vinnytsia.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before Loperamide medicine use the Hydrochloride surely consult with the attending physician.