Magnikor

Магникор Drug photo

The description is actual on 27.03.2015

  • Latin name: Magnikor
  • ATH code: B01AC06
  • Active ingredient: Acetylsalicylic acid + Magnesium hydroxide (Acetylsalicylic acid + Magnesium hydroxide)
  • Producer: Kiev vitamin plant of joint stock company (Ukraine)

Structure

One tablet contains active components: acetylsalicylic acid and magnesium hydroxide.

Additional components are: corn and potato starch, microcrystallic cellulose, magnesium stearate and mix for a film covering.

Release form

Magnikor in the form of tablets 75 and 150 of mg, film coated, packed on 10 pieces into blisters is issued. 10 or 3 blisters enter one packaging.

Pharmacological action

The antiinflammatory, febrifugal, antiagregantny and anesthetizing action is characteristic of drug.

Pharmacodynamics and pharmacokinetics

Tablets Magnikor possess all actions caused by the active components which are his part. The inhibition of tromboksanovy and prostaglandinovy synthesis belongs to the main pharmacological effects acetylsalicylic acid. Manifestation of analgetic effect happens thanks to TsOG inhibition. Under the influence of this component there is irreversible suppression of production of prostaglandins of the classes G/H. It is noted that such influence remains even after removal of drug from an organism. There is it because of action of the main component on synthesis of thromboxane which is in thrombocytes. It is expressed by increase in a bleeding time that is normalized with formation of new thrombocytes.

Antiacid action causes magnesium hydroxide and a factor which provides protection with a mucous gastrointestinal tract from the irritating influence of aggressive acetylsalicylic acid.

In an organism there is a fast absorption of drug in mucous a gastrointestinal tract. Meal slows down its absorbability. The maximum concentration of substances as a part of blood is found within 30 min.-2 hours. Linkng with plasma proteins is characteristic of acetylsalicylic acid that makes about 80-90%.

The connected salicylates and small part of magnesium get through placental and other barriers, and also into breast milk.

The metabolism of drug occurs in mucous a stomach therefore active metabolitessalicylates are formed. Removal of drug happens mainly by means of kidneys in metabolites – and small part in an invariable look.

Indications to use

Appoint Magnikor to patients at:

  • treatment of chronic and acute forms of coronary heart disease, for example: unstable stenocardia, acute myocardial infarction;
  • to prevention of repeated formation of blood clots;
  • to prevention of pathologies of cardiovascular system, for example, acute coronary syndrome;
  • hypercholesterolemia;
  • obesity;
  • diabetes mellitus.

Besides, tablets are appointed to patients till 55 flyings which transferred a myocardial infarction.

Contraindications to use

The tablet Magnikor is not appointed at:

  • individual intolerance of drug;
  • exacerbation of stomach ulcer;
  • the increased risk of developing of the bleedings caused by deficit of vitamin K, an anemia, thrombocytopenia;
  • renal and liver failure of a severe form;
  • heart failure;
  • asthma or Quincke's edema;
  • last trimester of pregnancy;
  • children's age.

Side effects

At treatment by Magnikor various side effects, work-related important bodies and systems of an organism can develop. Therefore deviations in work nervous, respiratory, digestive, endocrine, immune and other systems are possible. The disturbances affecting a state and functions of blood and a lymph, for example are not excluded: increase of bleeding, anemia, prothrombinopenia, neutropenia, thrombocytopenia and other. Development of allergic reactions is quite often noted: small tortoiseshells, gemmoragichesky vasculitis, angioedema, purpura and so on.

Tablets Magnikor, application instruction (Way and dosage)

As the application instruction of Magnikor specifies, carrying out prevention and treatment of serious diseases with use of this drug are possible only on doctor's orders. The dosage and duration of therapy is established individually, considering complexity of a disease and feature of an organism of the patient.

Magnikor's pill is taken in the whole look, washing down with water. Also crushing, chewing or razlamyvany tablets is allowed.

Treatment of acute and chronic forms of coronary heart disease assumes daily reception of 150 mg of drug. The supporting daily dosage makes 75 mg.

At treatment of stenocardia and acute myocardial infarction appoint a daily dose within 150-450 mg. Begin to accept Magnikor at once at emergence of the first symptoms.

During prevention of a thrombogenesis recommend to accept 150 mg a day. Reception of tablets Magnikor of 75 mg provides the supporting daily dosage. For the purpose of prevention of disturbances of activity of cardiovascular system also recommend to accept daily 75 mg of this medicine.

Overdose

Prolonged use of drug in the raised dosages can become the reason of moderately severe chronic poisoning. It is shown by such symptoms as:

  • dizziness;
  • deafness;
  • vascular expansion;
  • sonitus;
  • strong perspiration;
  • confusion of consciousness;
  • nausea;
  • vomiting.

The severe form of poisoning is followed: spontaneous concern, hyperventilation of lungs, alkaloidal alkalosis, high temperature, ketosis and metabolic acidosis. Effects of a serious poisoning are: the oppression of a nervous system leading to a coma, a cardiovascular collapse and an apnoea.

Also overdose by acetylsalicylic acid is capable to cause an acute liver failure.

At the same time urgently carry out: a gastric lavage, give Absorbent carbon.

Important point is recovery of water and electrolytic balance to avoid dehydration, acidosis, a hyperpotassemia and a hyper pyrexia. As an effective method of elimination of salicylate from composition of blood serves the hemodialysis, hemoperfusion and alkaline diuresis.

Interaction

Magnikor's combination to anticoagulants – Warfarin, Heparin, Klopidogrel, Fenprokumon and hypoglycemic drugs strengthens their action.

The concomitant use of this drug with NPVS is contraindicated. The combination with antiacid means can reduce Magnikor's absorbability, with Probenetsid – reduces efficiency of each medicine.

Terms of sale

Magnikor 30 pieces release tablets without recipe, 100 pieces – only according to the recipe of the doctor.

Storage conditions

The place for storage of medicine has to be the dry dark place with room temperature, unavailable to children.

Period of validity

2 years.

Analogs

The main analogs are: Aspekard, Kardiomagnil and Magnil.

Action possess also similar: Paracetamol, Amizon, Kardiomagnil, Analginum.

Alcohol

During treatment by Magnikor it is necessary to refuse alcohol intake.

Apteka24

  • Magnikor, Kia
  • Magnikor, Kia

Paniapteka

  • Magnikor of the tab. p / about No. 100 the Kiev vitamin plant
  • Magnikor of the tab. p / about No. 100 the Kiev vitamin plant
  • Magnikor of the tab. p / about No. 100 the Kiev vitamin plant
  • Magnikor of the tab. p / about No. 100 the Kiev vitamin plant
Section: For blood
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