Magnesium Sulphate

Магния Сульфат Drug photo

The description is actual on 16.07.2015

  • Latin name: Magnesium sulfate International Nepatentirovanny Name (INN): Magnesium sulfate
  • ATH code: B05XA05
  • Active ingredient: Magnesium sulfate
  • Producer: Pharmaceutical factory of St. Petersburg of joint stock company (Russia), Ivanovo pharmaceutical factory (Russia), Kaliningrad farmfabrika (Russia), Pyatigorsk farmfabrika (Russia), DEKO company (Russia), Biochemist (Russia), Novosibkhimfarm (Russia), Borisovsky plant of medical supplies (Republic of Belarus)


In 1 ml of solution ampullary — magnesium of sulfate of 250 mg.

Release form

  • Powder for dissolution in water of 10 g, 20 g, 25 g and 50 g.
  • Solution in ampoules of 5 ml and 10 ml of 20% or 25%.

Pharmacological group

Microelements, vazodilatator, sedative.

Pharmacological action

Sedative, spasmolytic.

Pharmacodynamics and pharmacokinetics


What is magnesium sulfate? The state pharmacopeia defines magnesium sulfate (formula MgSOi) as medicine and specifies norms on its production and the highest doses of use. "magnesium sulfate" is appropriated to a product the OKPD24.42.13.683 code.

With water this substance forms hydrates, heptahydrate is most important from them — bitter, or Epsom salt is a magnesia as to its thicket call which is used in medicine. Is issued in the form of powder from which prepare solution or suspension for intake and in ampoules for intramuscular and intravenous administration.

Depending on a way of introduction has different effect on an organism. At parenteral administration (pricks)sedative, diuretic, vasodilating, anticonvulsant, hypotensive, spasmolytic, antiarrhytmic, tokolitichesky, somnolent.

The action mechanism as anticonvulsant is connected with the fact that magnesium reduces release of a mediator of acetylcholine from synapses, suppressing a neuromuscular transmission, operates oppressing on TsNS.

Tokolitichesky action (relaxation of muscles of a uterus) is explained by the fact that magnesium reduces sokratitelny ability of a uterus and strengthens in it a blood stream.

Antiarrhytmic action is caused by stabilization of cellular membranes and decrease in excitability of cardiomyocytes. Effects after intravenous administration develop at once, later intramuscular — in 1 h.

At oral administration has cholagogue effect and serves as a purgative which is applied at locks or to purgation, at blind sounding, poisonings with salts of heavy metals (is an antidote). Laxative action is caused by bad absorbability in intestines in which osmotic pressure increases and water collects that attracts fluidifying of contents of intestines and strengthening of a vermicular movement.

Solution for injections can be used for intake as a purgative. The beginning of effect at intake in 1-3 h, lasts 4-6 h.

Magnesium sulfate also found the application in cosmetology at production of emulsions, lotions and creams. It is used as the weakening bath salt which removes a muscle tension.


At parenteral administration (pricks) gets through GEB. In maternal milk creates the concentration exceeding twice concentration in blood. It is removed by kidneys, the speed of removal is proportional to the level of glomerular filtering. At removal diuresis amplifies.

At oral administration it is badly soaked up in intestines. At malabsorption and the use of greasy food absorption of magnesium decreases. It is deposited in bones, muscles, kidneys, a myocardium.

Indications to use

Magnesium Sulphate powder is applied inside at:

  • locks;
  • diskineziya of a gall bladder, cholangites and cholecystitises (for carrying out tyubazhy);
  • duodenal sounding;
  • poisoning with salts of heavy metals;
  • for purgation.

Contraindications on Magnesium Sulphate

  • arterial hypotension;
  • heavy HPN;
  • the expressed bradycardia;
  • hypersensitivity;
  • AV blockade;
  • the period before childbirth (for 2 h);
  • oppression of a respiratory center.

With care appoint at a myasthenia. Contraindications for intake: appendicitis, intestinal bleeding, impassability of intestines, dehydration (dehydration).

Side effects

At intravenous use: a headache, a polyuria, decrease in the ABP, nausea, the expressed sedation, a uterus atony.

Gipermagniyemiya signs: bradycardia, doubling in eyes, an asthma, the muffled speech, an adynamy, decrease and loss of tendon jerks, oppression of a respiratory center and disturbance of cordial conductivity.

At intake: vomiting, diarrhea, exacerbation of diseases of a gastrointestinal tract, meteorism, thirst, intestines pains, disturbance of electrolytic balance (fatigue, adynamy, spasms).

Application instruction of Magnesium of Sulphate (Way and dosage)

The application instruction of solution in ampoules

25% solution are applied intravenously or intramusculary most often. At hypertensive crises, a convulsive syndrome, spastic states appoint 5–20 ml of drug.

At an eclampsia — on 10 – 20 ml of 25% of solution to 4 times a day.

For stopping of spasms at children enter 0,1-0,2 ml in oil on kg of the weight of 20% solution.

At acute poisonings — in/in 5–10 ml of 10% solution.

Magnesium powder Sulphate, application instruction

How to accept magnesium sulfate as a purgative? Powder in number of 20-30 g is dissolved in 100 ml of water (better than warm) and drunk for the night or in the morning for half an hour to food. At a chronic lock do enemas — the same amount of powder on 100 ml of water. Drug as laxative can be used only incidentally.

Powder route of administration as cholagogue means

Prepare solution from 20 g of powder and 100 ml of water. Accept on 1 tablespoon 3 times a day to food. At poisoning with salts of heavy metals accept inside solution — 20-25 g on 200 ml of water. At duodenal sounding through a probe enter 50 ml of 25% of solution.

Sulfate and as fertilizer — the separate section is devoted to it is applied magnesium.

Use as fertilizers

Magnesium sulfate — fertilizer which is a source of magnesium and sulfur for agricultural and decorative cultures. This fertilizer represents crystals of white color, well soluble in water. Accelerates growth of new escapes and increases quantity of a harvest, improves tastes of vegetable cultures due to increase in content of sugar, starch and vitamins. For prevention of deficit of magnesium it is recommended to bring every year from 50 to 100 g of bitter salt on sq.m. During vegetation to carry out root and extra root top-dressings.

Use for plants causes a gain and promotes violent blossoming. For example, for roses take 1 tablespoon of powder on a bucket of water and water each bush of 2 l of this solution. Top-dressing is carried out in June and to the middle of July as it causes the strengthened growth of escapes. It is possible to carry out also extra root top-dressings by spraying. For working solution take 20 g of drug on 10 l of water.


Overdose at intravenous administration is shown by disappearance of a knee jerk, sharp lowering of arterial pressure, nausea, vomiting, bradycardia, respiratory depression and TsNS.

Treatment: gluconate / chloride calcium solution in/in slowly (antidote), an oxygenotherapy, an artificial respiration, symptomatic therapy.

Overdose at intake — diarrhea. The symptomatic treatment is carried out.


Use with cardiac glycosides increases risk of AV of blockade, with muscle relaxants — neuromuscular blockade amplifies. At combined use with vazodilatator the hypotensive effect amplifies. The probability of oppression of a respiratory center and TsNS at use with barbiturates and narcotic analgetics increases.

Salts of calcium reduce effect of drug. The deposit from clindamycin by phosphate, polymyxin B, a hydrocortisone, Procainum a hydrochloride, salicylates, the drugs Ca2+, ethanol, salts of strontium, arsenic acid, barium is formed.

Terms of sale

Without recipe.

Storage conditions

At a temperature up to 25 Pages.

Period of validity

3 years.

Use at pregnancy

Drug at pregnancy is used at threat of premature births. As the antikonvulsant having hypotensive action he is choice drug for treatment and prevention of spasms at an eclampsia. Therapy there begin if diastolic ABP> 130 mm of mercury. Magnesian therapy is carried out by 24-48 more hours after the delivery. Criteria of the termination of therapy is disappearance of spasms, lack of a hyperreflexia of convulsive readiness, permanent decrease in the ABP, diuresis normalization. Use of this drug is at the time of delivery contraindicated as it reduces sokratitelny activity of a myometrium.

Magnesium sulfat-DarnitsaKormagnezin.

About Magnesium Sulphate

Often as the purgative is applied Magnesium powder Sulphate About which contradictory. Laxative action is shown at all differently: it is more or less expressed. Many note considerable strengthening of a vermicular movement and emergence of abdominal pains. Not all can drink bitter, unpleasant solution which sometimes causes vomiting.

It is necessary to remember that administration of drug is contraindicated at cholelithiasis, the lowered arterial pressure. The good effect gives this means when carrying out blind sounding.

Magnesium sulfate is applied to weight loss — responses are given below.

Magnesium Sulphate for weight loss

Before any diet it is desirable to clear intestines and this means it is applied disposable. Why it is impossible to resort to such method of purgation often? Magnesium sulfate irritates mucous with a gastrointestinal tract, breaks water-salt balance and at frequent use leads to dysbacteriosis. It was told above about how to accept powder for the purpose of purgation.

For the purpose of weight loss it is possible to take baths, adding a glass of powder or is one bathtub more. Time of reception of a bathtub of 15-20 minutes. It is necessary to take a bath before going to bed, on a course of 15 procedures which are carried out 2 times a week. After procedure it is necessary to take cover a warm blanket to achieve plentiful sweating. Action is that excess liquid is removed, puffiness is eliminated and exchange processes accelerate. The effect of weight loss occurs due to liquid loss, but through all the time comes back. Many consider such method as the emergency means for weight loss — responses confirm it.

The Sulphate Magnesium price where to buy

It is possible to buy Magnesium Sulphate in all drugstores of Moscow and other cities of Russia. Magnesium powder Sulphate which price depends on the number of grams costs within 38-58 rub.


  • Magnesium sulfate 25,0 poroshoktulsky pharmaceutical factory of Ltd company
  • Magnesium sulfate poroshokvologodsky farmfabrika state unitary enterprise
  • Magnesium sulfate of 25% solution for injections of 5 ml No. 10 ampulyborisovsky ZMP
  • Magnesium sulfate of 25% 10 ml No. 10 of amp. A microgene - NPO Virion
  • Magnesium sulfate of 25% 5 ml No. 10 ampulymikrogen - NPO Virion

Drugstore of IFC

  • Magnesium sulfate powder 25g, Tula FF (Tula) Russia
  • Magnesium sulfate solution for in 25% 5 ml No. 10, Groteks Ooorossiya
  • Magnesium sulfate solution for in 25% 5 ml No. 10 *, Mikrogen of NGO (Immunopreparauf) Russia
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  • Magnesium of a sulfatviol of FF (Ukraine, Zaporizhia)
  • Magnesium sulfatgalichfarm (Ukraine, Lviv)
  • Magnesium sulfatgalichfarm (Ukraine, Lviv)
  • Magnesium of sulfatdarniyets (Ukraine, Kiev)
  • Magnesium sulfatniko (Ukraine, Makiivka)


  • Magnesium sulfate of a time. 25ggalichfarm


  • Magnesium sulfat-Darnitsa 25%/5 ml No. 10 solution for in.amp. Darnitsa (Ukraine)
  • Magnesium sulfate 25%/5 of ml No. 10 solution for in.amp. Borisovsky ZMP (Belarus)
  • Magnesium sulfate 25%/5 of ml No. 5 solution for in.amp.
  • Magnesium sulfate of 25 g powder in Bang. Pharmacy Karaganda (Kazakhstan)
  • Magnesium sulfate 25%/5 of ml No. 10 solution for in.amp. Biosynthesis (Russia)
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Section: Others
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before Magnesium medicine use Sulphate surely consult with the attending physician.