Макрогол Constitutional formula

The description is actual on 29.02.2016

  • Latin name: Macrogolum
  • ATH code: A06AD65, A06AD15
  • Chemical formula: C2nH4n+2On+1
  • CAS code: 25322-68-3

Chemical name

Pauly (oxyethylene)

Chemical properties

The macrogoal, what is it? Makrogol is a polymer of ethylene glycol. Depending on the molecular mass of connection, it is in different aggregate states. It is liquid, gel or solid substance. Constitutional formula of substance: HO−(CH2−CH2−O)n−OH.

Polyethyleneglycol is used in various industries as binding component of solid rocket fuel, solvent, a cryoprotector, an osmotik for imitation of conditions of a drought in experiences on plants, the reagent replacing a lava when modeling underwater eruptions. Also means is applied in the form of a food additive of E1521, as a basis for cosmetics and various ointments, a purgative.

Usually at the mention of means in instructions add its molecular weight to the name of substance. In medicine use Makrogol 4000 and Makrogol 6000.

Pharmacological action


Pharmacodynamics and pharmacokinetics

The mechanism of effect of drug is based on ability of polyatomic alcohol to form hydrogen bindings with water molecules. Thus, getting into a gastrointestinal tract, this substance connects water, increases the content of liquid in a chyme, stimulates fast evacuation of fecal masses, stimulates an intestines peristaltics. Means prevents loss of electrolytes with a stake.

High-molecular Makrogol is not soaked up through gastrointestinal tract walls, does not get into a system blood stream, does not exert impact on acidity of the environment. It is removed in not changed look through intestines.

Indications to use

Means is appointed:

  • for a symptomatic treatment of locks at adults and children since 8;
  • by preparation for a kolonoskopiya, surgical interventions and X-ray inspections.


Substance is contraindicated to reception:

  • at ulcers and erosion mucous large intestine;
  • to patients with full or partial intestinal obstruction;
  • at a medicinal allergy;
  • if at the patient pains in a stomach of not clear etiology are observed;
  • to children till 8 flyings;
  • at an illness Krone, ulcer colitis, toxic megacolon.

Extra care is recommended to be observed at heart failure, dehydration and the other expressed disturbances in a condition of the patient.

Side effects

The macrogoal is well transferred by patients. However there is a list of side reactions which can develop in treatment time this substance.

Are possible:

  • allergic reactions to drug, rash, hypostases, urticaria;
  • diarrhea, painful feelings in a stomach, feeling of discomfort and weight;
  • vomiting and nausea, meteorism;
  • urgent desires to defecation, up to an incontience a calla (reception of high doses).

Macrogoal, application instruction (Way and dosage)

Inside. According to the recommendation of the doctor.

Usually drug is appointed in a dosage of 10-20 grams, once a day. Medicine is drunk since morning on an empty stomach, in time or before food. Effect of drug begins 1-2 days later after reception. Treatment duration is also defined by the doctor.

By preparation for research of intestines or operation substance is accepted according to recommendations of the attending physician. Means is drunk in 18-20 hours before procedure. It is necessary to drink 3 liters of solution with Makrogol's addition, on 200 ml each 20 minutes. Further it is possible to eat only liquid food. It is necessary to stop meal at ten o'clock evenings on the eve of operation.


At overdose there is severe diarrhea. As treatment it is recommended to lower a daily dosage or to interrupt therapy. Owing to excess loss of liquid electrolytic disturbances can develop. Diarrhea passes independently 1-2 days later after cancellation of medicine.


The macrogoal can slow down process of absorption of medicines which were accepted in parallel with drug. It is necessary to observe an interval at 2 o'clock between drug intakes.

Terms of sale

The recipe is not necessary.

Storage conditions

Medicine is stored far from small children, at observance of temperature condition.

Period of validity

3 years.

Special instructions

Drug cannot be used for a long time.

There are data on the cases of aspiration arising owing to Makrogol's introduction and electrolytes through a nazogastralny probe. Especially children with the broken swallowing function are subject to risk of aspiration.

Allergic reactions to drug develop seldom (rash, hypostases, urticaria). Isolated cases when the patient had an acute anaphylaxis are registered.

To children

Means is appointed to children of 8 flyings.

Trade names of this substance: Lavakol, Realaksan, Forlaks, Fortrans, Osmogol, Tranzipeg, Forteza Romfarm.

Means is in a combination with sodium chloride and potassium iodide as a part of drug Polioksidin.

Also substance is a part of the following medicines: Lavakol, Moviprep, Polioksifumarin, Endofalk.

About Makrogole

About Makrogole generally good. Positively doctors speak of drug and recommend to use drug for treatment of locks if other, not medicinal methods were inefficient. Medicine possesses high performance against low probability of development of side effects. This chemical compound does not irritate chemoceptors of a mucous membrane of intestines and does not damage them, even at prolonged treatment.

Patients also positively speak of drug. The truth of some of them does not suit the fact that sometimes the effect of reception develops within several days. Some consider means insufficiently effective. If Makrogol was appointed the attending physician and the patient followed recommendations of the specialist during treatment, then substance is well transferred.

Makrogol's price where to buy

Makrogol's price in the form of powder for preparation of solution for intake of Forlaks, 10 bags on 10 grams makes 150 rubles.

Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance use Makrogol surely consult with the attending physician.