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In 1 ml of solution — a meldony dihydrate of 100 mg.
In 1 capsule — a meldoniya of 250 mg or 500 mg. Magnesium stearate, potato starch, silicon dioxide — as excipients.
- capsules of 500 mg and 250 mg;
- solution for injections.
Anti-ischemic, cardioprotective (improves a metabolism and power supply of a myocardium).
Pharmacodynamics and pharmacokinetics
Has cardioprotective effect, besides membranostabiliziruyushchy and immunotropny. Limits the speed of synthesis of a carnitine from a γ-butyrobetaine that attracts disturbance of transport of fatty acids in a mitochondrion. Under the influence of drug the level of a γ-butyrobetaine which strengthens formation of an oxide of nitrogen that attracts reduction of OPSS and a vazodilatation increases.
Meldony reduces ability of thrombocytes to aggregation and improves elasticity of membranes of erythrocytes. In the conditions of ischemia prevents disturbance of transport of ATP. At ischemic damage of a cardiac muscle slows down formation of a zone of a necrosis. At heart failure increases contractility of a myocardium and reduces quantity of attacks of stenocardia. It is effective at pathology of vessels of an eyeground. Increases working capacity. Eliminates disturbances of a nervous system at patients with an alcoholism.
It is well soaked up at intake. Bioavailability at such way of introduction of 78% and 100% at intravenous administration. Cmax is defined in blood by 1-2 h. It is metabolized with formation of two metabolites, they are removed by kidneys in not changed look.
Indications to use
- ISCHEMIC HEART DISEASE;
- the lowered working capacity;
- dishormonal cardiomyopathy;
- postoperative rehabilitation;
- disturbances of cerebral circulation;
- physical overstrain;
- abstinence syndrome at an alcoholism.
- retinal apoplexy;
- disturbance of blood circulation in a retina;
- retina vein thrombosis;
- retinopathies (diabetic and hypertensive).
- The increased intracranial pressure;
- feeding by a breast;
- aged to 18 (capsules).
All side reactions meet seldom:
- psychomotor excitement;
- dispeptic frustration;
- changes of the ABP (decrease or increase);
- skin itch;
Meldony, application instruction (Way and dosage)
Capsules Meldony-Mick accept inside and in connection with a possibility of exciting effect they are recommended to be accepted in the morning. The dose and frequency rate of reception are selected individually.
At cardiological diseases — 500 mg-1000 of mg a day. Treatment lasts till 6 weeks.
At disturbances of cerebral circulation — 500 mg once a day, a course of 4-6 weeks.
At an abstinence syndrome — 500 mg 4 times a day.
At physical overworks — 250 mg 4 times a day, a course of 14 days.
Solution for injections
Usually the dose makes 0,5-1 g a day daily. The drug is administered on 10 ml 0,9% of NaCl solution.
Unstable stenocardia, state after the postponed myocardial infarction — enter in/in struyno 1–2 ampoules (500–1000 mg) 4 days in a row once a day. Stable stenocardia: dosage and frequency rate same introductions.
Parabulbarno is entered by 0,5 ml of solution.
Drug is a little toxic and cases of overdose do not meet or meet extremely seldom. Development of hypotension, tachycardia, headache, dizziness and the general weakness is theoretically possible. The symptomatic treatment is carried out.
Strengthens action of hypotensive, anti-anginal means, cardiac glycosides.
The combination to anti-anginal drugs, anticoagulants, antiarrhytmic means and diuretics is possible.
Not to apply along with the other drugs containing meldoniya.
Terms of sale
It is released according to the recipe of the doctor.
Temperature of storage is up to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
Purpose of this drug in complex treatment of cardiological pathology for 55,6% reduces quantity of attacks of stenocardia and daily need for nitroglycerine by 55,1%. Significantly improves reductions of a myocardium without influences on a cordial rhythm, limits fluctuations of the ABP. Drug malotoksichen also does not cause the expressed side reactions.
Judging by responses of patients, this means was appointed at an ischemic heart disease in a combination with anti-anginal and hypotensive drugs. Important that drug was appointed by the patient of the senior age groups and they well it transferred.
- "... Me added a tablet Meldony at stenocardia, to other tablets. Noticed improvement in 3 weeks";
- "… Accepted after a microinsult in capsules 2 times a day. Spent on drink one and a half months — the speech improved, cheerfulness appeared";
- "… I accept courses three times a year. I can characterize it as vital for all. I have a stenocardia and is a little raised the ABP";
- "… To the child year, very much I am tired. According to the recommendation of the neuropathologist I accept Meldony twice a day. I drink only week and already best of all I feel";
- "… I was recommended by the neuropathologist (the diagnosis "chronic fatigue"). Pricked pricks. Excellent drug, quickly returns forces";
- "… Noticed that Meldoniya's reception increases appetite a little, even recovered a little";
- "… After 7 days of reception of this drug became the head is turned".
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