Мертенил Drug photo

The description is actual on 03.07.2014

  • Latin name: Mertenil
  • ATH code: C10AA07
  • Active ingredient: Rozuvastatin of calcium (Rosuvastatin)
  • Producer: Gedeon Richter (Hungary)


Drug Mertenil as a part of one tablet contains active agent rozuvastatin calcium – 10,4 mg, and also excipients: cellulose microcrystallic 12, magnesium hydroxide, magnesium stearate, lactoses monohydrate, krospovidon (type A).

Is a part of a film cover opadray the II white (talc, titanium dioxide (E171), a macrogoal 3350 and polyvinyl alcohol).

Release form

Round and biconvex tablets in a film cover with an engraving of "C34". 10 pieces in one strip planimetric packaging (on 3 pieces in one cardboard pack).

Pharmacological action

Hypolipidemic drug for prevention and treatment of atherosclerosis. Reduces the level of cholesterol of lipoproteins of low density and increases the level of cholesterol of lipoproteins of high density.

Pharmacodynamics and pharmacokinetics

Mertenil's tablets are the selection and competitive inhibitor of enzyme which turns GMG-KOA in mevalonat. At use has the main effect where carries out synthesis of cholesterol and a catabolism of LPNP (lipoproteins of low density). Contacts proteins of a blood plasma approximately for 90%. The metabolism is limited – 10%.

Rozuvastatin of calcium reduces the level of the general cholesterol and LPNP cholesterol. Drug is removed from an organism naturally. Its system exposure increases in direct ratio to the accepted dose.

It is effective for treatment of people with a hypercholesterolemia, regardless of gender and age.

The maximum concentration of active agent in a blood plasma is reached approximately in 5 hours after reception of the corresponding dose. Bioavailability makes about 20%.

The first effect of use of medicine is swept up in a week. The greatest possible positive changes are reached after 1 month of reception and supported at further use of drug.

Indications to Mertenil's use

Indications to Mertenil's use can be the following:

  • hypercholesterolemia;
  • the combined dislipidemichesky states;
  • gipertriglitseridemiya of the IV type across Fredrikson;
  • family homozygous hypercholesterolemia;
  • prevention and treatment of atherosclerosis;
  • prevention of cardiovascular complications (heart attack, arterial revascularization, stroke and so forth).

Medicine is quite often appointed as addition to a dietotherapy when dietary food and other methods of lipidosnizhayushchy therapy, for example, exercise stresses, work insufficiently.


Mertenil in tablets on 5, 10 and 20 mg is not recommended to accept:

  • to pregnant women;
  • in the period of a lactation;
  • to the women of childbearing age using unreliable contraceptives;
  • at a liver failure;
  • at use of fibrat with cyclosporine;
  • in case of a lack of lactase and a lactose intolerance;
  • at functional problems with kidneys;
  • to people with predisposition to miotoksichesky complications;
  • in case of a myopathy;
  • at hypersensitivity and individual intolerance of some components of medicine;
  • in case of glyukozo-galaktozny malabsorption.

Mertenil's pill on 40 mg is forbidden to be taken at:

  • hypothyroidism;
  • excessive use of alcoholic beverages;
  • liver diseases in an active phase;
  • personal or family anamnesis of diseases of muscular tissue.

Similar dosages also do not recommend to patients of Asian race.

Besides, Mertenil with care appoint at:

  • metabolic, electrolytic and endocrine disturbances of heavy degree;
  • uncontrollable epilepsy;
  • arterial hypotension;
  • sepsis;
  • the increased risk of emergence and development of a myopathy;
  • disease baking in the anamnesis;
  • injuries;
  • extensive surgical interventions.

Besides, people should accept circumspectly this means 65 years are more senior. And its efficiency and safety for children are not established yet.

Side effects

Widespread side effects of Mertenil can be the following:

In rare instances there can be rash, a skin itch, a myopathy, a rabdomioliza, pancreatitis, the small tortoiseshell. And at regular reception of tablets on 40 mg development of a mialgiya, proteinuria and myopathy is possible. In addition, at such dosage concentration of bilirubin and glucose can increase, and also to be broken work of a thyroid gland.

Besides, if you accept Mertenil, the application instruction indicates that seldom or never there can be an arthralgia, jaundice, hepatitis, memory loss, an asthma, peripheral hypostases, diarrhea, a hamaturia, a polyneuropathy, cough.

However side effects which can be caused by Mertenil's use, as a rule, short-term or moderately expressed. In many cases they depend on a drug dosage. So the application instruction of Mertenil has to be observed strictly.

At unexpected muscle pains or emergence of muscular weakness which is followed by a febricula and fever immediately stop administration of drug and see a doctor.

Application instruction of Mertenil

It is possible to accept drug at any time inside with a small amount of water. However its reception should be combined with the dietary food coordinated with the specialist. The daily diet has to consist of products with the low content of fats.

In each case the medicine dose for the patient is selected individually. First of all, it depends on the treatment purpose. At correction of a dosage the general level of cholesterol at each patient, and also risk of emergence of cardiovascular complications and possible side effects is considered.

The minimum dosage, as a rule, 5-10 mg a day. Gradually (but not earlier than in a month) the dose can be increased. It is better to take a pill in 40 mg under continuous supervision of the doctor.


In case of overdose the symptomatic treatment is carried out. The hemodialysis is ineffective. It is important to control functions of a liver and a degree of activity of KFK.


Mertenil it is very important to combine with other medicines correctly. If you accept:

  • Cyclosporine – Mertenil's AUC (the area under a curve "concentration time") raises by 7 times.
  • Ezetimib – change in indicators of AUC and concentration of both drugs. Probability of emergence of the undesirable phenomena.
  • Inhibitors of proteases — lengthening of systemic action of Mertenil is possible.
  • Erythromycin — reduction of AUC0-t and Mertenil's Cmax.
  • Antagonists of vitamin K – increase INR (the international normalized relation) is possible.
  • Gemfibrozil and other means reducing the level of lipids – increase twice concentration and Mertenil's AUC. The risk of emergence of a myopathy is possible. Simultaneous use of tablets of Mertenil on 40 mg and fibrat is forbidden. The dose of a rozuvastatin should not be higher than 5 mg.
  • Antacids – in suspensions, the containing aluminum or magnesium hydroxide, can cause reduction of concentration of Mertenil in a blood plasma approximately on a half.
  • Oral contraceptives and gormonozamestitelny therapy – increase in AUC ethinylestradiol by 26% and Norgestrelum for 34% is possible.
  • P450 cytochrome isoenzymes – perhaps insignificant increase in AUC of Mertenil.

Terms of sale

Drug is available only according to the recipe of the doctor.

Storage conditions

It is necessary to store tablets Mertenil in the dry and protected from hit of direct sunshine place. Temperature has to be not above 30 °C.

Period of validity

Drug is stored 2 years.

Mertenil's analogs

Mertenil's analogs, components, code of automatic telephone exchange and which form of release match:

  • Klivas 10, Klivas 20;
  • Krestor;
  • Roviks;
  • Rozart;
  • Rozvator;
  • Rozuvastatin Sandoz;
  • Rozukard 10, Rozukard 20, Rozukard 40;
  • Rozulip;
  • Rock sulfur;
  • Romazik;
  • Fastrong.

All of them are on sale in tablets in a film cover. The cost of tablets in 10 mg fluctuates on average from 65 to 150

The price of Mertenil's analogs on a code of automatic telephone exchange of the 4th level on average from 40 to 80

About Mertenile

At forums About Mertenile generally positive. As a rule, it does not cause side effects. Overall health of the patients taking a pill for cholesterol does not worsen.

Specialists, in turn, discuss whether use of statines is justified in general and what dosages of this drug in each case have to be.


  • Mertenil of 40 mg No. 30 of a tablet
  • Mertenil of 5 mg No. 30 of a tablet
  • Mertenil of 20 mg No. 30 of a tablet
  • Mertenil of 10 mg No. 30 of a tablet

Drugstore of IFC

  • Mertenil tbl p / about 10 mg No. 30, Gedeon Richter-RUS Zaorossiya
  • Mertenil tbl p / about 20 mg No. 30, Gedeon Richter-RUS Zaorossiya
  • Mertenil tbl p / about 5 mg No. 30, Gedeon Richter-RUS Zaorossiya
  • Mertenil tbl p / about 40 mg No. 30, Gedeon Richter-RUS Zaorossiya
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  • Mertenil
  • Mertenil


  • Mertenil of 100 mg No. 30 Gideon Richter
  • Mertenil of 100 mg No. 30 Gideon Richter
  • Mertenil of 100 mg No. 30 Gideon Richter


  • Mertenil of 10 mg No. 30 tabl.p.p.o.
  • Mertenil of 20 mg No. 30 tabl.p.p.o.
  • Mertenil of 5 mg No. 30 tabl.p.p.o.
  • Mertenil of 40 mg No. 30 tabl.p.p.o.
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Section: Cardiovascular
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Mertenil surely consult with the attending physician.