Metadoksil

Метадоксил Drug photo

The description is actual on 23.04.2016

  • Latin name: Metadoxil
  • ATH code: N07BB
  • Active ingredient: Metadoksin (Metadoxine)
  • Producer: Doppel Farmaceutici (Italy), Laboratoire Baldacci (Italy)

Structure

  • 1 tablet of drug Metadoksil includes 500 mg of a metadoksin. Additional substances: magnesium stearate, MKTs.
  • 5 ml of solution for injection introduction include 300 mg of a metadoksin. Additional substances: water, sodium metabisulphite, methyl-p-hydroxybenzoate, edetat sodium.

Release form

  • White tablets biconvex a round form with a notch on one party and the name of medicine on other party. 10 pieces in the blister, 3 or 1 blister in a paper pack.
  • Transparent colourless solution. 5 ml of solution in a glass ampoule, 5/10 ampoules in PVC pallet, 2/1 PVC pallet in a paper pack.

Pharmacological action

Gepatoprotektivny, disintoxication, antialcoholic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Gepatoprotektorny effect of the medicine is based on ability to regulate a ratio of fatty unsaturated and saturated acids. It increases resistance of cells of a liver to impact of peroxide oxidation of molecules of fats by toxic agents.

Disintoxication action is caused by induction of the enzymes of a liver participating in ethanol transformation that lowers its toxic effect.

Metadoksin also prevents increase of content of triglycerides in hepatocytes, slows down formation of fibronectin and collagen in them that considerably slows down developments of cirrhosis. Improves cogitative activity and work of short memory, stimulates neyrotransmitterny GABA ергическую and cholinergic systems, emergence of motor excitement which is provoked by ethanol stops.

Accelerates stopping of symptoms of an abstinence syndrome, smoothes its somatic and mental manifestations.

Metadoksin has anksiolitichesky and nonspecific antidepressive action.

Pharmacokinetics

After oral administration it is actively absorbed in intestines and has bioavailability of equal 65-80%.

Reaction with blood proteins makes 50%.

It is transformed in a liver to active derivatives – carboxylat of a pirrolidon and pyridine. Time of semi-removal makes 45-55 minutes. About a half of drug is removed by kidneys within a day, another 35-45% are brought by intestines within four days.

Indications to use

Indications to use of tablets:

  • diseases of a liver, mainly alcoholic etiology, as a part of complex treatment;
  • alcoholism.

Indications to solution use:

  • abstinence syndrome of alcoholic genesis;
  • acute alcoholic poisoning.

Contraindications

  • pregnancy and lactation;
  • hypersensitivity to drug components.

It is recommended to apply with care medicine at Parkinson's illness if the Levodopa as metadoksin weakens his action is jointly applied.

At solution of drug there is a sodium metabisulphite capable to cause in predisposed persons allergic reactions or increase in force and frequency of attacks of asthma at having bronchial asthma.

Side effects

Development of allergic reactions, emergence of a bronchospasm in persons with bronchial asthma is not excluded.

Application instruction of Metadoksil (Way and dosage)

Tablets Metadoksil, application instruction

Pill is taken on 1 piece twice a day orally in 25-30 minutes prior to reception of food. If necessary it is authorized to increase a dosage to 3 tablets a day.

Duration of therapy makes usually not less than 3 months.

Solution Metadoksil, application instruction

At therapy of acute alcoholic poisoning depending on weight of intoxication enter 300-600 mg (1-2 ampoules) of drug intramusculary or 300-900 mg (1-3 ampoules) of drug intravenously. At an intravenous way of introduction the necessary dose of drug is dissolved in 500 ml of physical solution or solution of 5% of glucose and entered for 90 minutes kapelno.

At treatment of an alcoholic abstinence syndrome enter intravenously infusionally 900 mg (3 ampoules) of drug of times a day for 4-7 days depending on weight of a condition of the patient.

Overdose

There are no data on the occurred overdose cases drug.

Interaction

At simultaneous use drug lowers efficiency of the Levodopa.

Terms of sale

Only according to recipe.

Storage conditions

To store in the dark at a temperature up to 25 degrees. To protect from children.

Period of validity

5 years.

Special instructions

Influence on ability of the patient to manage motor transport is absent.

Analogs

Metadoksil's analogs: Adepress, Antabusum, Ataraxum, Baklosan, Hydroxyzinum, Biotredin, Vivitrol, Demanol, Gammalonum, Diazepam, Cocarboxylase, Zoreks, Colm, Lidevin, Ksanaks, Limontar, Mebicarum, Lutsetam, Mebiks, Nootobril, Napotonum, Oxazepam, Pikogam, Orvagil, Sibazonum, Tazepamum, Sonapaks, Teturamum, Topral, Flokset, Tiaprid, Unithiolum, Elenium.

Zdravzona

  • Metadoksil of 500 mg No. 30 of a tablet
  • Metadoksil of 5 ml No. 10 of amp.

Drugstore of IFC

  • Metadoksil tbl 500 mg No. 30, Baldacci Lab.Italiya
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Section: For a nervous system
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Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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