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One tablet of drug Metandiyenon contains 10 mg of the active agent of the same name.
Additional substances: krospovidon, magnesium stearate, dye red, povidone, lactose.
Pink, square, flat tablets with roundish edges, with a notch and letters of "BP" on the one hand and a text "10" on the other hand. The mramornost on a tablet surface is admissible.
Twenty tablets in the blister; three blisters in a box from a cardboard.
Pharmacodynamics and pharmacokinetics
Steroid anabolic steroid. Affects a cellular kernel, stimulating the genetic device that leads to activation of synthesis of RNA, DNA and structural proteins, enzymes of tissue respiration and increase in oxidizing phosphorylation, tissue respiration, biosynthesis of ATP and accumulation of makroerg in a cell.
Suppresses catabolic changes after reception of glucocorticosteroids and stimulates anabolic processes. It leads to increase in mass of muscles, decrease in an adiposity, improves food of fabrics, promotes increase in content of calcium in skeleton bones, detains phosphorus, nitrogen, potassium, sulfur, sodium and water. Stimulates erythropoetin synthesis. Weak androgenic activity promotes development of characteristic secondary sexual characteristics.
It is quickly soaked up from a digestive tract. Bioavailability low is also connected with effect of transhepatic first passing. In blood for 90% contacts globulins carriers. Metabolites are inactive. It is removed with urine.
Duration of action reaches 14 hours.
Indications to use
- Osteoporosis of various nature; the progressing dystrophy of muscles;
- cachexia of various nature;
- disturbance of an exchange of proteins after infectious diseases, severe injuries, burns, surgical interventions, radiation therapy;
- prevention of osteoporosis and myopathy against treatment by glucocorticosteroids.
- Sensitization to drug;
- cancer or adenoma of a prostate;
- prostatitis (acute or chronic);
- serious illness of a liver or insufficiency of function of a liver;
- diabetes mellitus;
- heart attack, coronary heart disease and heart failure;
- breast cancer at men;
- pregnancy and lactation.
- Dyspepsia: nausea, diarrhea, vomiting, abdominal pains;
- jaundice, hepatocellular carcinoma;
- allergic reactions;
- strengthening of bleeding;
- depression, sleeplessness;
- adenoma and adenocarcinoma of a prostate;
- emergence of the centers of consolidations in a mammary gland;
- virilescence: a hirsutism, suppression of normal function of ovaries, irreversible lowering of a timbre of a voice, baldness, changes of a menstrual cycle, increase in a clitoris (for women);
- gynecomastia (for men);
- polyuria and pollakiuria;
- leukemoid test;
- progressing of atherosclerosis;
- closing of regions of growth ahead of time at children.
Application instruction (Way and dosage)
Metandiyenon accept orally before food. For adults the initial dose makes 10-15 mg a day, in special cases it can be raised to 30 mg a day. The greatest single dose – 10 mg, the greatest day dose – 50 mg. As a maintenance dose 5-10 mg a day are appointed.
To children of 6-4 years appoint 5 mg of times a day or time in two days.
The course of treatment can reach about one month. The repeated course is possible after a 6-8-week break.
Signs: strengthening of undesirable effects.
Therapy: gastric lavage, symptomatic treatment.
At emergence of symptoms of virilescence Metandiyenon it is necessary to cancel.
Stimulates effects of antiagregant, anticoagulants, hypoglycemic drugs and undesirable effects of hepatotoxic means.
Terms of sale
Strictly according to the recipe.
- To store at a temperature of 25 degrees in the dark dry place;
- to protect from children.
Period of validity
During treatment by drug it is regularly necessary to exercise control of indicators of a lipidemiya and cholesterinemia.
For achievement of the best effect along with drug use the patient has to use enough carbohydrates, fats, proteins, vitamins and minerals with food.
Use of drug for the purpose of stimulation of muscle growth at athletes is inadmissible and can do heavy harm to health.
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