Metrogil Plus

Метрогил Плюс Drug photo

The description is actual on 17.05.2016

  • Latin name: Metrogyl Plus
  • ATH code: G01AF20
  • Active ingredient: Clotrimazolum + Metronidazole (Clotrimazole + Metronidazole)
  • Producer: Unique Pharmaceutical Laboratories (India)


Metrogil Plus contains metronidazole and Clotrimazolum in structure, and also propilgidroksibenzoat, propylene glycol, methylhydroxybenzoate, carbomer-940, dinatrium edetat, sodium hydroxide, benzyl alcohol, water.

Release form

HP let out in the form of gel vaginal. It is homogeneous, white or almost white, opalescent gel. Contains in tubas on 20 g, 30 g, also the applicator is included in the package.

Pharmacological action

Metrogil Plus – the combined means for use intravaginalno. As a part of two ingredients — metronidazole and Clotrimazolum.

Activity of metronidazole in relation to protozoa is noted: Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, to gram-negative anaerobe bacterias: Prevotella spp. Fusobacterium spp., Bacteroides fragilis, Gardnerella vaginalis. Also substance is active concerning Peptostreptococcus spp., Clostridium difficile, Clostridium perffringens, Peptococcus spp.

The substance Clotrimazolum exerts bactericidal and fungicidal impact. Substance provides braking of biosynthesis of ergosterol which regulates permeability of a wall of cells of microorganisms. In low concentration provides a fungistasis, in high — fungicidal.

Substance in fungicidal concentration enters interaction with mitochondrial enzymes and peroxidases. As a result, concentration of peroxide of hydrogen to toxic increases, and there is a death of mushrooms.

High activity in relation to a number of mushrooms, dermatophytes, the elementary, gram-positive bacteria is noted.

Pharmacokinetics and pharmacodynamics

The substance Metronidazole after introduction is intravaginalno soaked up in a system blood stream approximately for 56%. Bioavailability of metronidazole in the form of gel vaginal is twice higher, than in the form of vulval tablets at single use of 500 mg of means. The maximum concentration of substance is observed in 6-12 hours after introduction. Easily gets into body tissues, passes through a placenta, through GEB, gets to breast milk. Contacts proteins of plasma less, than for 20%.

The metabolism occurs in a liver. 60-80% are brought from an organism with urine (about 20% — in not changed look) and 6-15%

If Clotrimazolum is applied intravaginalno, then no more than 3-10% are soaked up systemically. For 2-3 days high concentration of a component in a vaginal secret, and also low – in blood remain. The metabolism occurs in a liver — inactive metabolites are formed.

Indications to use

Metrogil Plus it is reasonable to apply in the following cases:


Gel is contraindicated at:

  • leukopenias (also in the anamnesis);
  • organic lesions of TsNS (epilepsy , etc.);
  • liver failure;
  • pregnancies – in the first trimester;
  • high sensitivity to means components.

Side effects

In the course of use of this means such negative manifestations can develop:

  • local effects: the burning sensation, a frequent urination, at the man (the sexual partner) is possible feeling of irritation and burning of a penis;
  • system manifestations: nausea, a headache, dizziness, spastic pains in the field of an abdominal cavity;
  • allergy: urticaria, rash on skin.

If at the patient the symptoms or any other negative effects described above develop, he needs to stop therapy at once and to address the doctor.

The instruction on Metrogil Plus (A way and a dosage)

The application instruction provides that gel is entered to patients intravaginalno. It is recommended to enter on once 5 g of gel Metrogil Plus, that is one hollow applicator. It is necessary to enter means in the morning and in the evening. Treatment continues five days if there is a need, repeated treatment is practiced in two weeks.


When using medicine in those doses which are designated in the instruction overdose symptoms at patients were not observed.


When using along with reception of indirect anticoagulants action of the last amplifies.

It is not necessary to apply together with not depolarizing muscle relaxants (vekuroniya).

If Metrogil Plus is applied together with lithium drugs, then concentration of lithium in blood can increase.

The metabolism of metronidazole accelerates Phenobarbital and reduces Cimetidinum

At simultaneous use with Clotrimazolum its efficiency is reduced by Nystatin, Amphotericinum In, Natamitsin.

Disulfiramopodobny reactions at use along with ethanol are possible.

Terms of sale

According to the recipe.

Storage conditions

To protect from children, to store up to 25 °C in temperature condition.

Period of validity

It is possible to store gel 2 years.

Special instructions

During use of gel it is impossible to take alcoholic drinks as such combination can lead to development of disulfiramopodobny reaction, the shown headache, vomiting, nausea, pain in a stomach, rushes of blood to the person.

It is necessary to consider that in the course of treatment the false positive test of Nelson as substance metronidazole can immobilize treponemas can be noted.

It is possible to apply means exclusively vnutrivaginalno.

It is not necessary to allow its hits in eyes.

It is important to abstain from sexual contacts during therapy.


Now analogs Metrogil Plus on active components are absent.


  • Metrogil plus 50 g gel vaginal with the applicator (1 applicator) Unique Pharmaceutical Lab.
  • Metrogil plus 50 g gel vaginal with the applicator (10 applicators) Unique Pharmaceutical Lab.
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  • Metrogil Plus of 30 g gel of levers. Yunik Farmasyyutikal Laboratoriz (India)
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Section: Gynecologic Antimicrobic
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Metrogil Plus surely consult with the attending physician.