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Mianserina hydrochloride, calcium hydrophosphate, potato starch, silicon dioxide, methyl cellulose, polietilenglyukol, talc.
Tablets of 30 mg in a film cover in the blister in cardboard packaging No. 20.
Pharmacodynamics and pharmacokinetics
Drug from group of piperazino-azepinovy connections in which structure there is no lateral chain which is present at tricyclic antidepressants. Drug blocks α2-адренорецепторы and breaks process of the return capture of noradrenaline. Mianserin contacts serotoninovy receptors of a brain. Has the expressed anksiolitichesky effect that is of great importance in therapy of patients with the depression caused by an alarming state. Sedation is connected with influence of drug on histamine and α1-адренорецепторы, allows to use it for treatment of the sleep disorders developing against depressions.
Drug has no anticholinergic activity and practically does not influence function of cardiovascular system that allows to appoint it patients of advanced age and to the patient having cardiovascular diseases. In cases even of the expressed overdose cardiotoxic effects it is much less concerning effect of tricyclic antidepressants.
Mianserin is quickly soaked up in a gastrointestinal tract. Bioavailability of drug at the level of 20%, a svyazyvayemost with blood proteins high (95%). Cmax in blood is reached in three hours after administration of drug, and stable concentration in blood is reached during six-day reception. T1/2 varies from 20 to 60 hours, it is enough to accept drug of 1 times a day. It is metabolized by oxidation and demethylation, removed for a week with urine and a stake.
Indications to use
Depressions of various origin.
The expressed abnormal liver functions, maniacal states.
Emergence of drowsiness in an initial stage of treatment by drug is possible. Seldom – abnormal liver functions, process of a hemogenesis, emergence of peripheral hypostases, spasms, decrease in the ABP, manifestation of a hypomaniacal state, bradycardia, an arthralgia, a hyperkinesia, increase in body weight is possible.
Miaser, application instruction (Way and dosage)
Miaser it is necessary to swallow of tablets without chewing, once a day, washing down with a small amount of water. For adults the initial recommended drug dose – 30 mg a day. In need of it it is possible to raise gradually (each 3 days) to achievement of necessary clinical effect. Maximum drug should not exceed 90 mg. In most cases the effective daily dose is equal to 60-90 mg. The effective supporting daily dose administration of drug in quantity has to be a little lower than the accepted dose. It is better to accept a daily dose in one step, in the evening, proceeding from positive influence of drug on a night dream of the patient, but in need of it it is possible to distribute on 2-3 receptions.
The effect of treatment (monotherapy) at correctly picked up dose comes after 2–4 weeks of administration of drug. If efficiency insufficient, Miaser's dose it is possible to increase. If the positive effect for the next month is not observed, administration of drug needs to be stopped and passed to other HP. After improvement of a clinical picture for maintenance of a positive effect administration of drug it is necessary to continue a current of 5-6 months on an extent. It is necessary to stop administration of drug not sharply, and gradually reducing a dose.
At prolonged use of drug in the doses exceeding therapeutic development of long sedation is possible. Arterial hypotension, arrhythmias, respiratory depression and spasms develop extremely seldom.
During treatment by drug it is impossible to accept alcohol the containing drinks as at the same time the oppressing effect of alcohol on TsNS considerably amplifies. It is not necessary to accept Miaser together with MAO inhibitors and within 2 weeks after the end of reception of these drugs. At a concomitant use of Miaser and anti-hypertensive HP it is necessary to control the ABP level. Miaser can exert impact on a metabolism of the HP which are coumarin derivatives.
Terms of sale
According to the recipe.
At a temperature up to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
About drug positive. Drug is effective at a depression, disturbances of a night dream.
- "… I had very severe sleeplessness against a depression. The constant alarm, fear, concern, nightmares, lack of a dream did not stop Trittico and Melitor. On the advice of the neurologist I began to accept Miaser. The effect at me came in 4 days. Accepted on 1 tablet within two months, with further reduction of a dose to 1/4 tablets. Is as it seems to me, insignificant accustoming. I will pass to administration of drugs of a plant origin".
Section: For a nervous system
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