Mifegin

Мифегин Drug photo

The description is actual on 01.08.2014

  • Latin name: Mifegyne
  • ATH code: G03XB01
  • Active ingredient: Mifepristone (Mifepristone)
  • Producer: EXELGYN Laboratoires, MACORS Laboratoires (France)

Structure

As a part of one biconvex tablet of Mifegin of light yellow color, with the put code 167B 20 mg contain. actively operating compound of the micronized mifepristone.

Corn starch, colloid silicon dioxide, magnesium stearate, microcrystallic cellulose and povidone are a part of drug as excipients.

Release form

Mifegin let out in the tableted form. In one cardboard packaging there are, as a rule, 3 blisters with medicine, with a total nominal amount of 200, 400 or 700 mg.

Pharmacological action

Drug makes antiprogestagenny impact.

Pharmacodynamics and pharmacokinetics

As the chemical compounds which are a part of drug possess antigestagenny influence, Mifegin already at the level of receptors blocks effect of progesterone. Due to this communication with receptors when using drug the antagonism with GKS is noted.

Besides, drug stimulates in horiodetsidualny cells release process interleykina-8, thereby increasing sokratitelny ability at myometriums, and also sensitivity to prostaglandins.

Under the influence of drug there is an ekspulsiya of fetal egg and desquamation of a decidua. For efficiency strengthening Mifegin quite often combine with synthetic analogs of prostaglandin.

Necessary concentration of actively operating connection in an organism is reached in 1,3 hours after a single dose of medicine. Getting to plasma, mifepristone contacts an acid alfa1-glycoprotein and albumine for 98%.

At a stage of removal of actively active ingredient for 12-18 hours its concentration in an organism gradually goes down. Completely mifepristone to be removed from an organism within 72 hours after the end of use of drug.

Indications to use

Drug is used, as a rule, at medicamentous abortion on terms till 42 days, and also in house conditions as means of an emergency contraception within 72 hours after the unprotected sexual intercourse. To all other, Mifegin apply at the full-term pregnancy to induction and preparation for childbirth, and also at treatment of a leiomyoma of a uterus.

Contraindications

The main contraindications to use of drug are the following diseases and states:

  • insufficiency of adrenal glands;
  • renal or liver failure, including chronic or acute forms of diseases;
  • hypersensitivity to compound components of drug;
  • long period of treatment by glucocorticoids;
  • hem on a uterus;
  • porphyria;
  • heavy extragenital pathologies;
  • diseases of generative organs;
  • anemia;
  • disturbances in a hemostasis.

It is forbidden to use Mifegin for abortion in the presence:

At induction or by preparation for childbirth drug is not recommended to be used in the presence:

Drug is not used during treatment of a leiomyoma of a uterus in the presence:

  • pregnancy which term exceeds 12 weeks, and also in the period of a lactation;
  • tumors of ovaries;
  • submucous arrangement of myomatous nodes;
  • hyperplasia endometria.

Side effects

When using drug there can be such side effects as: weakness, discomfort in the lower part of a stomach, a headache, vomiting or nausea, dizzinesses, diarrhea, an enanthesis, and also a gipetermiya.

In addition to the listed above indispositions when using drug during medicamentous abortion there can be such additional side effects as bleeding, an exacerbation of infections of generative organs and urinary tract, and also an inflammation of appendages and a uterus.

When sharing of Mifegin and Mizoprostol hemoglobin level can decrease, develop dyspepsia, an adynamy and a vaginitis. Besides, there can be unconscious states and disturb onychalgias.

Use of drug as an emergency contraception can cause disturbance of a menstrual cycle and bloody allocations. In the course of treatment of a leiomyoma by means of Mifegin the amenorrhea can develop.

Application instruction of Mifegin (Way and dosage)

According to the instruction on Mifegin, drug is intended only for use under supervision of the doctor in medical institution. Medicine is not recommended for use for the purpose of continuous contraception, and also does not protect from diseases, sexually transmitted.

For abortion accept 600 mg. means in the presence of health workers who on an extent of 2 hours have to carry out supervision over the patient. After 48 hours after drug use, the patient has to make ultrasonography, and in 14 days – to repeat ultrasonic research and to pass survey at the gynecologist finally to confirm abortion.

As means, preparatory to childbirth, drug accept 200 mg in a dose. also in the presence of physicians. Within 24 hours repeated reception of medicine in the same dose is shown. After 72 hours after repeated administration of drug, and also after carrying out an assessment of a condition of patrimonial ways doctors can appoint Oxytocin or Prostaglandin.

Overdose

When using in the doses, safe for an organism, which are not exceeding 2 g, Mifegin does not cause undesirable side reactions. At overdose epinephral insufficiency is observed.

Interaction

For effective treatment by Mifegin it is necessary to avoid within 12 days after administration of drug of use of non-steroidal anti-inflammatory drugs.

Terms of sale

It is released for needs of the specialized medical institutions having the license for rendering obstetric and gynecologic services.

Storage conditions

Drug belongs to group A and demands a certain temperature condition of storage (strictly not above 25 °C).

Period of validity

3 years.

Special instructions

As Mifegin use for medicamentous abortion, patients have to be informed on obligatory need of passing of medical examination within 14 days after direct use of medicine. In cases when drug does not achieve the goal (the continuing pregnancy, incomplete abortion) it is necessary to carry out immediately vacuum aspiration as mifepristone provokes development of heavy malformations  of a fruit.

Drug has to be used in medical institution and therefore that before its reception, as well as to operational abortion it is necessary to pass some specific researches, for example, the prevention of a Rhesus factor-alloimmunizatsii.

During treatment by means of Mifegin the patients having an infectious endocarditis or with an artificial heart valve it is necessary to use antibiotics at the same time.

Mifegin's analogs

Now there are following analogs of Mifegin on actively operating component:

That it is better: Mifepristone or Mifegin?

In essence both of these drugs are intended for medicamentous abortion, and also are used at a stage, preparatory to childbirth. Mifepristone as well as Mifegin has the extensive list of contraindications and is allowed for use only in medical institutions where at emergence of side effects or complications doctors will be able to give to the patient immediate help.

Section: Gynecologic Contraceptives
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