Микосист Drug photo

The description is actual on 26.06.2016

  • Latin name: Mycosyst
  • ATH code: J02AC01
  • Active ingredient: Flukonazol (Fluconazole)
  • Producer: Gedeon Richter, Hungary


Active component is Mikosist's part: flukonazol.

Additional components of drug in capsules: silicon dioxide colloid, magnesium stearate, talc, corn starch, povidone, lactose anhydrous.

Solution for infusions, except the main substance, also contains sodium chloride and water for injections.

Release form

Mikosist in the form of capsules and solution for infusions is issued.

Capsules of 50 mg, 100 mg and 150 mg are packaged in blisters, on 1, 2 or 4 in packaging.

Solution for infusions is placed in the glass, carefully corked bottles, and packed together with the plastic holder for droppers.

Pharmacological action

All forms of drug possess antifungal action.

Pharmacodynamics and pharmacokinetics

Substance flukonazol is the representative of a class of derivatives of triazole and belongs to the selection inhibitors of synthesis of the sterol occurring in cells of mushrooms. It is capable to block process of transformation of a lanosterol of mushrooms at the level of cells in ergosterol. At the same time increase in permeability of a cellular membrane is noted. Androgenic activity is not characteristic of it.

This drug shows high performance at treatment of diseases which cause Candida spp., Microsporum spp., Cryptococcus neoformans, Trichophyton spp., Coccidioides immitis Blastomyces dermatitidis and so on.

At reception of capsules in an organism or its introduction flukonazol about 80-90% are exposed to good absorption, with bioavailability. Meal does not exert impact on its absorption. As a rule, treatment with this drug is begun with higher dosage for increase of concentration of substance and full recovery. The main component is found practically in all fabrics, physiological liquids as it without effort breaks all barriers of an organism. Out of an organism of Mikosist it is brought by means of kidneys.

Indications to use

This drug is shown to use at:

  • various forms of a cryptococcosis;
  • treatment and prevention of candidiases;
  • to prevention of fungal infections at patients with malignant new growths, having predisposition to similar infections because of chemotherapy cytostatics, beam therapyand and so on;
  • mycoses of skin of different localization and other fungal infections of integuments.


Mikosist is not appointed at:

  • sensitivity to it;
  • lactose intolerances, deficit of lactase and glyukozo-galaktozny malabsorption – for capsules;
  • lactations.

At pregnancy drug is appointed with care, having compared advantage of treatment with possible infliction of harm to a fruit.

Side effects

Treatment by Mikosist can be followed by the side effects mentioning various systems and bodies. Therefore such symptoms as can be shown: nausea, vomiting, abdominal pains, diarrhea, meteorism, food faddism, problems with work of a liver, headache, spasms, dizziness.

Also disturbance of work from bodies of a hemopoiesis is not excluded, development of allergic reactions and other failures of activity of an organism.

Application instruction of Mikosist (Way and dosage)

The application instruction recommends to accept drug of Mikosist inside or to enter intravenously, depending on a dosage form. At the same time transition from one form to another does not demand change of a daily dosage.

It should be noted that purpose of dosing, the therapeutic scheme and duration of use depends on a look and complexity of disturbance, and also specific features of the patient. During purpose of capsules the dosage of 100 or 150 mg which can double at the beginning of therapy is usually used. Anyway it is possible only under control of the attending physician.


Emergence of accidental overdose can be shown by such symptoms as diarrhea, nausea, vomiting, convulsive states, hallucinations.

For elimination of signs of overdose carry out the symptomatic treatment including a gastric lavage, a hemodialysis, an artificial diuresis and so on.


At purpose of this drug together with anticoagulants of a coumarinic row it is necessary to control carefully PV which can raise.

The combination to drugs of a sulfonilmochevina is capable to cause development of a hypoglycemia.

Simultaneous use with Phenytoinum, the Zidovudine and Cyclosporine quite often leads to increase in their concentration therefore dosing correction is required. Rifampicin is capable to lower concentration of a flukonazol.

The Mikosist can increase serumal concentration of Rifabutin that leads to development of a uveitis.

Contraindicated simultaneous use with Terfenadin, Tsizaprid, Theophylline, Midazol, Takrolimus as it can become serious threat for health and the patient's life.

Special instructions

It is necessary to carry out therapy flukonazoly to full kliniko-hematologic remission. When treatment stops prematurely, manifestation of recurrence is possible.

Care at purpose of drug is required for the patients having a renal failure and disturbances of functions of a liver.

During reception of a flukonazol dizziness therefore it is necessary to be careful during management of transport and the performance of work demanding extreme care can be shown.

Terms of sale

Drug in capsules is released without recipe.

While solution for infusions can be bought only according to the recipe.

Storage conditions

Storage of drug is possible in usual conditions, in the place unavailable to children.

Period of validity

5 years.

Mikosist's analogs

Main analogs of Mikosist: Flukonazol, Mikoflyukan, Diflucan, Mikomaks, Flucostat, Flukozan and others.

Mikosist or Flukonazol – what is better?

This drug has a set of analogs, one of them is Flukonazol. Therefore patients are always concerned by a question what of these drugs is better. The matter is that the main substance of each of these drugs is flukonazol. As for efficiency of these drugs, it cannot raise doubts. And here individual portability can differ. In other, as well as their cost.


  • Mikosist of 150 mg No. 2 kapsulygedeon Richter
  • Mikosist of 50 mg No. 7 kapsulygedeon Richter
  • Mikosist of 150 mg No. 1 kapsulagedeon Richter
  • Mikosist of 100 mg No. 28 kapsulygedeon Richter
  • Mikosist 2mg/ml solution for infusions of 100 ml No. 1 flakongedeon Richter

Drugstore of IFC

  • Mikosist kaps 150 mg No. 4, Gedeon Richtervengriya
  • Mikosist kaps 50 mg No. 7, Gedeon Richtervengriya
  • Mikosist kaps 150 mg No. 1, Gedeon Richtervengriya
  • Mikosist kaps 150 mg No. 2, Gedeon Richtervengriya
  • Mikosist kaps 150 mg No. 1, Gedeon Richter/Gideon-Richter-RUS Zaorossiya
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  • Mikosistgedeon Richter (Hungary)
  • Mikosistgedeon Richter (Hungary)
  • Mikosistgedeon Richter (Hungary)
  • Mikosistgedeon Richter (Hungary)
  • Mikosistgedeon Richter (Hungary)


  • Mikosist kaps. 100 mg No. 28 Gideon Richter
  • Mikosist kaps. 100 mg No. 28 Gideon Richter
  • Mikosist kaps. 100 mg No. 28 Gideon Richter
  • Mikosist kaps. 100 mg No. 28 Gideon Richter
  • Mikosist kaps. 100 mg No. 28 Gideon Richter


  • Mikosist of 50 mg No. 7 kaps.
  • Mikosist of 150 mg No. 1 kaps.
  • Mikosist of 150 mg No. 2 kaps.
  • Mikosist of 100 mg No. 28 kaps.
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Section: Antifungal
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