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Lactose, corn starch, talc, polividon 25000, magnesium stearate as excipients.
Dragee No. 21.
Pharmacokinetics and pharmacodynamics
Mikroginon is combined monophase is oestrogenic-gestagennym drug for contraception in which hormones contain in low doses. The mechanism of action consists in suppression of an ovulation at the level of a hypothalamus and a hypophysis, change of a cervical secret which becomes insuperable to spermatozoa. In the same time it causes changes of an endometria that makes impossible implantation.
At reception of the combined contraceptives the menstrual cycle is recovered, painful periods disappear, intensity of bleeding decreases.
Levonorgestrel is quickly soaked up and its maximum concentration in blood is defined in 1 hour. Bioavailability is almost full. Contacts blood proteins, and 1,3% are in a free look. It is completely metabolized. Concentration in blood decreases in two phases. T1/2 of a final phase of 20-23 hours. It is removed with urine and bile only in the form of metabolites. At daily reception the level of levonorgestrel increases by 3-4 times, and in the second half of a cycle equilibrium concentration is reached.
Ethinylestradiol is also well soaked up. Its maximum concentration in blood — in 1-2 hours. Its bioavailability about 45% is metabolized in a liver. For 98% communicates albumine. Decrease in concentration in blood also happens in two phases. T1/2 in the second phase — 10-20 hours. Metabolites are removed by kidneys and a liver. After one week of reception equilibrium concentration is reached.
Indications to use
Prevention of undesirable pregnancy.
Mikroginon it is impossible to apply at:
- cardiovascular diseases (defeats of valves of heart, disturbance of a rhythm, hypertensia, coronary heart disease);
- thrombophlebitises, thromboses and thromboembolisms;
- migraines with focal neurologic manifestations;
- long immobilization and surgeries standing;
- breast cancer;
- to myometrium carcinoma;
- estrogen - dependent tumors;
- liver diseases;
- pancreatitis with the expressed gipertriglitseridemiya;
- diabetes mellitus with defeat of vessels;
- pregnancies and lactations;
- uterine bleedings of not specified genesis;
- renal failure;
- hemophilia and the lowered coagulability of blood;
- serious immune illness;
- to excess body weight;
Mikroginon can cause:
- increase in mammary glands, their morbidity and intensity;
- headache, migraine;
- allocations from mammary glands;
- differences of mood;
- bloody allocations or plentiful uterine bleedings;
- change of a libido;
- increased fatigue;
- vision disorder and intolerance of contact lenses;
- nausea, vomiting, diarrhea, abdominal pains;
- changes of vulval secretion;
- generalized itch and skin rash;
- knotty erythema;
- development of thromboses and thromboembolisms;
- cholestatic jaundice;
- delay of liquid and increase in weight.
Application instruction of Mikroginon (Way and dosage)
To accept inside every day one after another, better at the same time. To accept continuously 21 days, after a week break start reception of the following packaging. During a break for 1-3 day after the last tablet cancellation bleeding begins. It can not end until reception of new packaging.
Begin reception in the first day of menstrual bleeding. If reception of a dragee is begun for 2-5 day of a cycle, it is necessary to apply in addition within 7 days barrier contraception.
Upon transition from other oral contraceptives it is necessary to begin administration of drug right after reception of an active dragee of other drug or after a week break of Mikroginon. If earlier the contraceptive like "was accepted mini-drank" or Mirren's contraceptive was used, then it is possible to pass to this drug in any day without interruption, but it is in addition necessary to apply barrier contraception within a week of reception of new drug.
After the delivery it is necessary to begin reception for 21-28 day. If terms were extended, it is necessary to apply a barrier method of contraception in addition. It is important that pregnancy was excluded, it is in that case better to wait for the first periods.
If reception of a dragee is missed and delay made menshe12 hours, then protection does not decrease. Administration of drug should not be interrupted, more, than for 7 days as week of continuous reception is necessary for suppression of ovarian regulation from gipotalamo-pituitary system.
The instruction on Mikroginon contains a detailed explanation how to accept drug in different situations: after abortion, for change of day of the beginning of periods how to behave in case of vomiting and what to do if day of reception of a dragee is missed. Having attentively studied the instruction and carrying out it, it is possible to avoid side reactions and unexpected situations.
It is shown by symptoms: bloody allocations, nausea, vomiting. The symptomatic treatment is undertaken.
Contraceptive action decreases at reception of ampitsillin and tetracyclines. Streptocides and derivatives of Pyrazyl ketone strengthen a metabolism.
At prolonged treatment by drugs which induce liver enzymes (Primidonum, Rifampicin, Phenytoinum, barbiturates, Carbamazepine, Okskarbazepin, Topiramat, Ritonavir, Felbamat, Griseofulvin) that is followed by increase of clearance of sex hormones and leads to massive bleedings and decrease in contraceptive activity.
Influences a cyclosporine metabolism, changing its concentration in plasma. At administration of drug correction of doses of indirect anticoagulants and hypoglycemic HP is necessary.
Terms of sale
According to the recipe.
Temperature of storage is not above 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
On activity the combined oral contraceptives containing analogs of women's hormones which are developed in different phases of a cycle — estrogen and gestagen are considered as the most effective.
There are monophase drugs in which doses of estrogen and gestagen are constant in all tablets and throughout all cycle of their concentration in blood will be identical. Mikroginon, Femoden, Diane-35, Rigevidonum, Jeanine, Logest treats them. Also exist two - and three-phase drugs in which the content of estrogen and gestagen changes. Variable doses of hormones imitate the physiological level of hormones at a menstrual cycle.
Comments of doctors on Mikroginona are connected, first of all, with the fact that there is no best or worst drug for contraception — it is all about portability and lack of side effects. But from the point of view of physiology of the woman, three-phase the COOK which imitate the content of hormones in blood more precisely combine big efficiency and a minimum of side effects.
There are women who for years (3-8 years) accept this drug and are very happy with it as it does not cause undesirable reactions in them. And is such who could not accept it more than a month.
The main criterion of the choice of drug for protection from pregnancy is the smallest dose of steroids which is sufficient for reliable protection. The preference has to be given to drugs in which estrogen no more than 30-35 mkg, and progestins — a dose of equivalent 150 mkg of levonorgestrel. This drug meets such requirements.
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