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In 1 ml of solution of Fluphenazin of a dekanoat of 25 mg.
Solutio oleosa for injections of 1 ml.
Pharmacodynamics and pharmacokinetics
Classical antipsychotic drug of long action. Eliminates hallucinations, uneasiness, irritability and nonsense. Action Moditenum of depot is caused by blockade of cerebral D2 and D1 receptors in three dopamine systems and more than other neuroleptics. It is characterized by bigger antipsychotic activity (by 25 times exceeds Chlorpromazinum). High clinical performance is followed by by-effects: extrapyramidal frustration and giperlaktonemiya.
Sedative action is expressed moderately and is explained by blockade of serotoninovy, adrenergic and histamine receptors. The expressed antiemetic action, and also antidepressive and normotimichesky is moderated.
It is especially effective at nuclear and it is long the current schizophrenia. Moдитен® of depot — drug in the prolonged form. Action continues 2 weeks and more that very important for reliable out-patient treatment of patients.
Active Fluphenazin is gradually emitted from depot and comes to blood. The effect develops for 24 — 72 h. It is metabolized in a liver, allocated with a stake and urine. An elimination half-life of 7 — 10 days, at repeated injections — till 14 days. Action continues from 15 to 35 days.
Indications to use
- nervoza with a behavior disorder (at elderly people);
- schizophrenia (all forms);
- paranoid states;
- maniacal excitement, aggression;
- fear, nervous tension;
- depressive and hypochiondrial syndrome;
- disturbances of consciousness of heavy degree;
- the expressed renal or heart failure;
- intoxication alcohol, antidepressants, sedative, hypnotic drugs, drugs, tranquilizers;
- pregnancy and feeding by a breast;
- age till 12 flyings.
- Often met side reactions: extrapyramidal frustration, late dyskinesia.
- Not often: tachycardia, perspiration, a headache, deterioration sight, glaucoma, a nose congestion, nausea, the raised sialosis or dryness in a mouth, locks, bladder paralysis, a gynecomastia, disturbances of an erection and menstrual cycle.
- Seldom: hyperthermia, muscular rigidity, lowering of arterial pressure, stupor, urine incontience, photosensitivity, dermatitis, small tortoiseshell, eczema, seborrhea, drowsiness.
- Very seldom: ventricular tachycardia, asthma, Quincke's edema.
At emergence of heavy reactions treatment stops.
Moditenum, application instruction (Way and dosage)
Moditenum of depot, application instruction
The dose and frequency of reception is selected the doctor individually. Injections are carried out deeply in a muscle. Solution for injections is not mixed with other solutions.
Most often the initial dose makes 12,5 — 25 mg. Pricks carry out Moditenum of depot with an interval of 15 — 35 days. The dose if necessary gradually increases by 12,5 mg, but should not exceed 100 mg.
If the patient did not receive a fenotiazina earlier, appoint Moдитен® in tablets, and then transfer to injections of the prolonged action.
Elderly people have enough dose of 3,125 and no more than 6,25 mg.
To teenagers of 12-18 years drug in a dose from 6,25 mg to 18,75 mg which is administered with an interval of 7-21 days is appointed. At a renal failure low doses are applied.
Drug is not used at a liver failure.
Injection therapy is sometimes supplemented with the tablets Moдитен®.
It is shown by heavy extrapyramidal disturbances, the expressed arterial hypotension, a hypothermia, an ischuria, disturbances of a heart rhythm (as at Quinidine overdose), block and disturbance of consciousness, lack of reflexes, spasms and a coma.
Symptomatic treatment. At arrhythmia sodium bicarbonate and magnesium sulfate are shown. At extrapyramidal disturbances — antiparkinsonichesky means, at arterial hypotension enter Noradrenaline.
At appointment with tricyclic antidepressants, MAO inhibitors the risk of a malignant antipsychotic syndrome, with antihypertensives — an orthostatic collapse, with gepatotoksichny — damages of a liver increases.
At use with drugs, the oppressing TsNS, respiratory depression, consciousnesses and psychomotor reactions is noted.
Drug increases glucose level in blood and reduces effect of alpha adrenoblockers.
Can lower a convulsive threshold in this connection dose adjustment of antiepileptic means is required.
Exponentiates effect of anticoagulants therefore control of a prothrombin ratio is necessary.
It is impossible to appoint adrenaline for the purpose of correction of reduced pressure against reception of Moditenum of depot as in combination with fenotiaziny, opposite reaction is noted. It is necessary to avoid use of antiarrhytmic means at treatment by this drug.
Terms of sale
According to the recipe.
In the dry place at a temperature not above 25 °C.
Period of validity
Mirenil, Prolinat, Fluphenazin.
Many patients accepting earlier different neuroleptics consider that Moditenum of depot removes negative symptomatology more effectively, than Rispolept. Therefore, in most cases responses positive. Administration of drug causes permanent, long remission. However, drug is not deprived of side effects what patients report about.
In the first days of treatment at some hypertensia, a hyperthermia and vegetative frustration (perspiration, pallor, heartbeat) was noted. Many noted the hyperkinesias of face muscles and a mouth, grimacing which are smacking the lips the movements of lips and language. As well as many depots drugs, this caused depressions of different severity too. The suppressed mood is shown in several months after an initiation of treatment.
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Section: For a nervous system
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