Moksonidin

Моксонидин Drug photo

The description is actual on 10.01.2015

  • Latin name: Moxonidine
  • ATH code: C02AC05
  • Active ingredient: Moksonidin (Moxonidine)
  • Producer: Northern star of closed joint stock company (Russia)

Structure

One tablet contains 200 mkg of active ingredient of a moksonidin.

As excipients cellulose microcrystallic is used, klutset, aerosil of the A-380 brand, castor oil, polyvinylpirrolidone, the twin-80, magnesium stearate.

Release form

Drug is issued in tablets coated, in cellular packaging on 14 pieces, in a cardboard pack there can be 14, 28 pieces – 1 or 2 blisters.

Pharmacological action

Anti-hypertensive effect.

Pharmacodynamics and pharmacokinetics

Active agent moksonidin is the selection agonist of imidazolinovy receptors and is responsible for tonic and reflex control over the sympathetic nervous system localized in a myelencephalon in ventero-lateral department. Drug is capable to reduce systolic and diastolic the ABP at one-time reception and long therapy due to decrease in pressor influence of sympathetic system on peripheric vascular resistance and peripheral vessels, without essential changes of cordial emission and ChSS.

Absorption happens for 90% regardless of meals. Bioavailability makes 88%, and 7% contact proteins of a blood plasma. Substance is capable to pass through a blood-brain barrier, to get into milk, long reception does not lead to accumulation. The concentration maximum in plasma is reached in 0,5-3 h and makes 1-3 pikogramm on ml, taking into account that the volume of distribution is in limits 1,4-3 liters on kg. An elimination half-life — several hours. 90% are brought by kidneys, and 70% — in not changed look, the rest — in the form of metabolites.

Indications to use

Drug is appointed at arterial hypertension in the anamnesis.

Contraindications

  • hypersensitivity to the components which are a part of drug;
  • syndrome of weakness of a sinus node;
  • disturbances of upper atrial and atrioventricular conduction of the 2nd – the 3rd degree;
  • the expressed bradycardia at ChSS is less than 50 blows in 1 minute;
  • severe forms of arrhythmia;
  • heart failure;
  • existence in the anamnesis of data on the endured Quincke's disease;
  • glaucoma;
  • the expressed disturbances of normal functioning of a liver and kidneys;
  • various disturbances of peripheral blood circulation, including Parkinson's illness, Raynaud's disease, obliterating atherosclerosis, Charcot's syndrome;
  • epilepsy;
  • depression;
  • unstable stenocardia;
  • intolerance of a galactose, either deficit of lactose, or malabsorption of glucose and galactose;
  • pregnancy or period of a lactation;
  • age category till 18 flyings.

Side effects

Drug Moksonidin can cause the following side reactions:

  • vomiting, dyspepsia, dryness in a mouth, diarrhea, nausea;
  • skin rash, itch;
  • increased fatigue;
  • asthenic state;
  • migraines;
  • dizziness (vertigo);
  • various sleep disorders or drowsiness;
  • nervousness;
  • orthostatic hypotension or bradycardia;
  • hypostases are peripheral.

Moksonidin, application instruction (Way and dosage)

Accept inside, since a dose of 200 mkg once a day. The most acceptable single dose has to be no more than 400 mkg whereas an admissible daily dose — to 600 mkg for two receptions. The application instruction of Moksonidin indicates the need corrections of a daily dose in an individual order on the basis of data on portability of therapy.

Overdose

Is followed by headaches and the dizziness, sedation, vomiting, spasms in a stomach which is excessively expressed by decrease in the ABP at the general weakness and dryness in a mouth. Treatment is appointed symptomatic in the form of a gastric lavage, by administrations of absorbent carbon and laxative.

Decrease in the ABP demands recovery of volume of blood by administration of physical solution, bradycardia is stopped Atropine.

Specific antidote Idazoksanthe well-known antagonist of imidazolines.

Interaction

Moksonidin with the following means and drugs gives combined use of drug to:

  • With antihypertensives — to the additive effect.
  • With tricyclic antidepressants, tranquilizers, ethanol, sedative and hypnagogues – strengthening of action of Moksonidin is possible.
  • Lorazepam — improvement of the weakened cognitive functions.
  • To strengthening of sedation of derivatives of benzodiazepine.

Terms of sale

According to the recipe.

Storage conditions

In the dry dark place not available to children, at a temperature no more than 25 ° Celsius.

Period of validity

Till three years.

Special instructions

Treatment demands regular control of the ABP, ChSS and an ECG, it is desirable to exclude alcohol intake, work with mechanisms and driving of the car, and also other types of activity which require special attention or high speed of reactions. It is necessary to stop a course gradually.

If cancellation at the same time of β-adrenoblockers and Moksonidina is necessary, then initially it is necessary to cancel β-adrenoblockers, then in several days it is possible to cancel Moksonidin.

Moksonidin's analogs

Coincidence on the ATH code of the 4th level:

Synonyms of this drug incorporate the same active agent whereas Moksonidin's analogs (or in a different way — generics) can only have similar therapeutic effect, among them are the most popular:

Zdravzona

  • Moksonidin-SZ 0,2mg No. 14 tabletkiseverny star of closed joint stock company
  • Moksonidin-SZ 0,4mg No. 28 tabletkiseverny star of closed joint stock company
  • Moksonidin-SZ 0,4mg No. 14 tabletkiseverny star of closed joint stock company
  • Moksonidin-SZ 0,2mg No. 28 tabletkiseverny star of closed joint stock company
  • Moksonidin of 200 mkg No. 20 of a tabletkifarmzashchit of NPTs
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Section: Cardiovascular
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Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

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