Моноприл Drug photo

The description is actual on 08.12.2014

  • Latin name: Monopril
  • ATH code: C09AA09
  • Active ingredient: Fozinopril (Fosinopril)
  • Producer: BRISTOL-MYERS SQUIBB (Italy)


One tablet of Monopril depending on a dosage may contain 20 or 10 mg of sodium of a fozinopril as active agent.

Additional substances: krospovidon, microcrystallic cellulose, lactose, polyvinylpyrrolidine, the stearylfumarating sodium.

Release form

Monopril is white, round, inodorous biconvex tablets, with a notch from one edge and an engraving "609" or "158" from another.

Is issued on:

  • 14 such tablets on 20 mg in the blister, two blisters in a paper pack;
  • 10 such tablets on 10 mg in the blister from plastic and aluminum foil, one or two blisters in a paper pack;
  • 14 such tablets on 10 mg in the blister from plastic and aluminum foil, one or two blisters in a paper pack.

Pharmacological action

Drug possesses hypotensive action.

Pharmacodynamics and pharmacokinetics


Inhibitor of an angiotensin-converting enzyme. Chemically fozinoprit sodium – sodium salt of ether of a fozinoprilat.
Fozinoprilat is the selection competitive blocker of an angiotensin-converting enzyme. After APF inhibition, it interferes with transformation of angiotensin of the first type in the angiotensin of the second type possessing angiotonic action. It leads to lowering of content of angiotensin of the second type in blood – it causes decrease in its vasoconstrictive activity and weakening of secretion of Aldosteronum.

Fozinoprilat brakes an exchange of bradikinin and therefore its anti-hypertensive effect amplifies. Pressure decrease is not followed by reduction or increase in the circulating volume of blood, a renal and brain blood-groove, blood supply of bodies. After internal reception the anti-hypertensive effect comes within one hour, becomes maximum in 2-5 hours and lasts about one days. Several weeks are necessary for achievement of the greatest therapeutic action.

Anti-hypertensive effects of thiazide diuretics and fozinopril complement each other.

Drug promotes reduction of sensitivity to an exercise stress, lowering of severity of heart failure.


After the peroral use absorption from intestines reaches 30-40% and does not depend on reception of food. The maximum concentration in plasma comes in three hours. Interaction with proteins of blood reaches 95%.

Enzymic hydrolysis of drug happens in a liver and mucous intestines. Fozinoprilat is brought equally through a digestive tract and kidneys. The elimination half-life is close by 11 o'clock.

Indications to use

Indications to Monopril's use:

  • heart failure;
  • arterial hypertension (both in the form of monotherapy and as a part of the combined treatment).


With care to apply at:

  • hyponatremias;
  • bipolar stenosis of renal arteries;
  • desensitizations;
  • aorta stenosis;
  • state after the postponed transplantation of a kidney;
  • renal failure;
  • systemic lesions of connecting fabric;
  • hemodialysis;
  • cerebrovascular diseases;
  • coronary heart disease; heart failure on chronic type 3-4 of degree;
  • diabetes mellitus;
  • hyperpotassemias;
  • oppression of a hemopoiesis in marrow;
  • to gout;
  • at advanced age;
  • states, followed by reduction of the circulating blood volume.

Side effects

The most probable side effects of Monopril.

  • From the blood circulatory system: stethalgias, faints, orthostatic hypotension, inflow, arrhythmia.
  • From digestion: vomiting, dyspepsia, pancreatitis, increase of maintenance of ALT and nuclear heating plant, hepatitis.
  • From a nervous system: sensitivity disturbances, feeling of fatigue.
  • From urinogenital system: oligouriya, proteinuria, increase of concentration of creatinine and urea.
  • From respiratony system: sinusitis, pharyngitises, cough, bronchospasm.
  • From a musculoskeletal system: joint pain and muscles.
  • Allergic reactions: photosensitization, itch, rash, Quincke's edema.

Application instruction of Monopril (Way and dosage)

The application instruction of Monopril recommends to accept drug inside. The dosage is selected individually.

Arterial hypertension. An initial dose – 10 mg of times a day. It is necessary to select a dose watching dynamics of pressure decrease. The standard dose fluctuates in the range of 11-40 mg of time a day. If the sufficient hypotensive effect is absent it is possible to appoint diuretics in addition.

Heart failure. An initial dose – 5 mg to two times a day. Over time about 40 mg a day are allowed to raise a dose.


Signs: strong pressure decrease, bradycardia, shock, disturbance of water and mineral balance, acute course of a renal failure, stupor.

Therapy: to stop Monopril's reception, a gastric lavage, the use of sorbents, angiotonic means, administration intravenously of physical solution, then a symptomatic and maintenance therapy. The hemodialysis is inefficient.


Simultaneous use with antacids reduces absorption of a fozinopril therefore they should be used with an interval at 2 o'clock.

At combined use with salts of lithium the risk of intoxication lithium increases.

Non-steroidal anti-inflammatory drugs suppress anti-hypertensive action of Monopril and similar drugs.

At simultaneous use of drug with diuretics excessive pressure decrease can develop.

Drugs the containing potassium and kaliysberegayushchy diuretics increase probability of development of a hyperpotassemia.

Fozinopril activates hypoglycemic effect of insulin and derivatives of a sulfonilmochevina; increases risk of emergence of a leukopenia at use with cytostatic means, immunodepressants, Allopyrinolum, Prokainamid.

Estrogen suppresses anti-hypertensive effect of Monopril.

Terms of sale

Drug can be bought according to the recipe.

Storage conditions

To store in the dry place in the range of temperatures of 15-25 degrees. To protect from children.

Period of validity

Two years.

Special instructions

Correction of the accepted dose of a fozinopril is not required from elderly persons. Safety of use at children is not established.

It is necessary to be careful when driving as emergence of dizziness, especially at initial stages of treatment is possible.

Monopril's analogs

The most widespread analogs of Monopril: Fozikard, Fozinap, Fozinotek, Fozinopril-Teva.


  • Monopril of 20 mg No. 28 tabletkibristol Myers Skvibb

Drugstore of IFC

  • Monopril tbl 20 mg No. 28, Bristol-Myers Squibbitaliya
  • Monopril tbl 20 mg No. 28, Searle/Syorl of Farm (Izvarino) Russia
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Section: Cardiological Cardiovascular
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Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
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