Мотилиум Drug photo

The description is actual on 09.11.2015

  • Latin name: Motilium
  • ATH code: A03FA03
  • Active ingredient: Domperidon (Domperidone)
  • Producer: Janssen-Silag (Belgium), Catalent U.K. Swindon Zydis (Great Britain)


It is not dependent on a release form medicine includes in structure domperidon as active agent.

Suspension Motilium contains the following additional components: sodium saccharinate, sodium carboxymethylcellulose, methylparahydroxybenzoate, sodium hydroxide, water, MKTs, sorbitol, propilparagidroksibenzoat, polysorbate.

Excipients of tablets for a rassasyvaniye – gelatin, aspartame, half-oxameasures 188, Mannitolum, mint essence.

Tablets Motilium in a cover include in structure lactose, microcrystallic cellulose, polividon, the vegetable hydrogenated oil, a gipromeloza, corn starch, gelated potato starch, magnesium stearate, sodium lauryl sulfate.

Release form

Medicine is issued in the form of biconvex round tablets of cream or white color. On the parties there are engravings of "Janssen" and "M/10".

Besides, white instant tablets for a rassasyvaniye and suspension (or syrup) in bottles are on sale.

Pharmacological action

The summary of drug indicates that this antiemetic activating motility of a gastrointestinal tract.

Pharmacodynamics and pharmacokinetics

Medicine inhibits dopamine receptors. This property in combination with gastrokinetichesky action causes antiemetic effect of drug.

At internal use Motilium increases pressure of the lower sphincter of a gullet, accelerates clarification of a stomach and promotes improvement of antroduodenal motility.

After reception on an empty stomach active agent of drug is in a short space of time soaked up from a gastrointestinal tract. Extent of absorption of a domperidon decreases because of reduction of acidity of a gastric juice. The maximum concentration in plasma is noted approximately in 0,5-1 hour. At people with a moderately severe abnormal liver function it can be 1,5 times higher, than at healthy.

Absolute bioavailability – about 15%. When using medicine after meals the maximum concentration is reached later. At healthy people bioavailability increases at use after food. In the presence of problems from a gastrointestinal tract it is necessary to use drug in 15-30 minutes prior to meals.

Extent of communication of active agent with proteins of plasma – 91-93%. Getting to an organism, it is exposed to fast and active biotransformation in a liver by means of a hydroxylation and N-dealkylation.

Drug for 31% is removed with urine and to 66% with a stake. About 11% of active agent are removed in an invariable look.

Time of semi-removal from plasma after single use – 7-9 hours. At people with a heavy renal failure the elimination half-life increases till 20,8 o'clock, and plasma concentration decreases. Only about 1% is brought through kidneys in an invariable look. People with an abnormal liver function have semi-removal time – 15-23 hours.

Indications to Motilium's use

Indications to Motilium's use: vomiting, a hiccups, nausea, an atony and hypotonia, cholecystitis, a reflux esophagitis, round ulcers of intestines, need of acceleration of a vermicular movement before X-ray contrast researches gastrointestinal tract, dyskinesia of zhelchevyvodyashchy ways, a cholangitis, a meteorism.

As making complex treatment drug accept at an aggravation of a peptic ulcer of a stomach and duodenum.

Indications to Motilium's use for children: gastroesophagal reflux, cyclic vomiting, vomiting syndrome.


Medicine has the following contraindications:

  • bleedings in a gastrointestinal tract, perforations, mechanical impassability;
  • prolaktinoma;
  • negative reaction of an organism to drug components;
  • dysfunction of a liver of heavy or average degree.

Drug is taken at dysfunction of kidneys, and also disturbances of a rhythm and conductivity of heart with caution.

About possible contraindications to use of medicine it is desirable to consult with the specialist.

Side effects

At reception of this medicine the following side reactions are possible:

Negative effects are noted only in extremely exceptional cases.

Application instruction of Motilium (Way and dosage)

The application instruction of Motilium reports that the scheme of reception can be different in dependence from what tablets or suspension are used in each case.

In case of chronic dyspepsia adults need to take medicine on 10 mg (1 tablet) on an empty stomach of 3 times/days. If there is a need, it is possible to use drug before going to bed. To those who use suspension and tablets Motilium the application instruction does not recommend to exceed a daily dosage in 80 mg.

Syrup children are given in a dosage 2,5 ml of medicine on 10 kg of weight. It is necessary to do it 3 times/days on an empty stomach. If necessary medicine is taken before going to bed.

The application instruction of Motilium for children of 1 year also reports that in case of need the dose can be raised twice. The maximum dosage in a day – 2,4 mg/kg, but is no more than 80 mg.

In case of nausea and vomiting accept syrup in a dosage 20 ml or 2 tablets. It is necessary to do it 3-4 times/days on an empty stomach and before going to bed. The daily dosage – is no more than 80 mg.

Suspension for children is given at the rate of 5 ml of funds for 10 kg of weight. Medicine is taken by 3-4 times/days on an empty stomach and before going to bed. The maximum day dosage – 2,4 mg/kg, but is no more than 80 mg.

Tablets can be given only to adults and children weighing from 35 kg. If body weight is less, it is necessary to use so-called children's Motilium in the form of syrup.

Before use the bottle with suspension needs to be stirred up well. That to open it, it is necessary to press on a plastic cover and to turn it. Further the cover in which there is a suspension Motilium is removed, the application instruction reports that it is necessary to take her only by means of a special pipette which is delivered together with drug.


Overdose symptoms: drowsiness, extrapyramidal reactions, disorientation.

The special antidote does not exist. At overdose it is desirable for patient to wash out a stomach and to give Absorbent carbon. It is necessary to watch a condition of the patient and to hold the supporting events.

In case of extrapyramidal reactions anticholinergic and antihistaminic medicines can be effective.


Anticholinergics can block Motilium's action. The antifungal drugs of group of azoles, inhibitors of HIV protease and antibiotics relating to group of macroleads can inhibit biotransformation of a domperidon and increase its contents in a blood plasma therefore it is necessary to appoint such combination to care.

Motilium and Ketokonazol's contraindicated simultaneous use in a peroral form, and also Erythromycin and strong inhibitors of an isoenzyme CYP3A4 which cause lengthening of an interval of QT.

Terms of sale

Without recipe.

Storage conditions

Optimum temperature is 15-30 °C. Medicine is stored in the place unavailable to small children.

Period of validity

Five years.

Motilium's analogs

Coincidence on the ATH code of the 4th level:

The following analogs of Motilium are known:

  • Domrid;
  • Bryulium Lingvatabs;
  • Motinol;
  • Gastropom-Apo;
  • Motinorm;
  • Domidon;
  • Domperidon Geksal;
  • Domperidon Sandoz;
  • Domperidon-Kredofarm;
  • Domperidon-Stoma;
  • Domrid Sr;
  • Motilak;
  • Motorikum;
  • Peridonium;
  • Nausilium;
  • Motoriks;
  • Peridon;
  • Perilium.

Some analogs are cheaper than Motilium. Nausilium, Motoriks, Motinorm, Domrid, Domidon treat those, for example.

Before accepting Motilium's analogs, it is necessary to study the instruction attentively. Some of them are not suitable for children.

What it is better – Motilium or Motilak?

To learn that Motilium or Motilak is better, it is possible only by practical consideration. Active ingredient of both drugs – domperidon. Motilium is issued in tablets and in the form of suspension, and Motilak only in the tableted form. Structure of auxiliary components at drugs different so in the presence of individual intolerance some of them, only one drug will approach.

Both medicines normalize and prolong a gastrointestinal tract peristaltics, relieve of vomiting and nausea. Besides, they promote elimination of heartburn, a meteorism and eructation.

The difference between them also consists in cost. Motilium is 2-3 times more expensive than Motilak. The people accepting both means claim that there is no qualitative difference between them.

Motilium for children

Suspension Motilium can be applied to children even at body weight to 35 kg. When using means it is necessary to watch a condition of the child. The most private side reactions at children's age – extrapyramidal reactions.


  • Motilium of 10 mg No. 30 tabletkiyansen-Silag
  • Motilium of 10 mg No. 30 of a tablet lingvalnyeyansen-Silag
  • Motilium ml suspension 100 flakonyansen-Silag
  • Motilium of 10 mg No. 10 of a tablet lingvalnyeyansen-Silag

Drugstore of IFC

  • Motilium tbl p / about 10 mg No. 30, Janssen Pharmaceuticafrantion
  • Motilium tbl lingv. 10 mg No. 10, Janssen Pharmaceuticabelgiya
  • Motilium susp. 1mg/ml fl 100 ml, Janssen Pharmaceuticabelgiya
  • Motilium tbl lingv. 10 mg No. 30, Janssen Pharmaceuticabelgiya
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  • Motilium of the tab. of 10 mg No. 10yanssen-Silag
  • Motilium of the tab. of 10 mg No. 10yanssen-Silag


  • Motilium of 10 mg No. 30 tabl.p.o.
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Section: Gastrointestinal
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Motilium surely consult with the attending physician.