And whether you know...
One milliliter of drug contains 400 mkg of Naloxonum of a hydrochloride of a dihydrate + excipients.
Also Naloxonum is issued in a special dosage for newborn children on 0,02 mg of active ingredient in 1 ml of solution.
Medicine is let out in the form of transparent liquid for injections in ampoules on 1 ml, in cardboard boxes on 10 ampoules.
Blocks opiate receptors.
Pharmacodynamics and pharmacokinetics
The mechanism of action of Naloxonum is based on ability of substance to force out specific antagonists of opiate recipes by the competitive principle. Active ingredient of morfinopodobny activity is deprived. Thanks to it drug also makes the therapeutic impact: recovers breath, eliminates hypotension, renders dysphoric and psychotomimetic effect.
Drug does not cause medicinal dependence, tolerance to means is not developed. If to give Naloxonum to the person who is periodically accepting opiates at it there will be an abstinence syndrome.
After introduction the therapeutic effect is reached within 2 minutes and lasts till 240 min. An elimination half-life for adults – of half an hour to an hour, for newborn children – about 3 hours. The metabolism undergoes means in a liver, is removed through kidneys. Medicine breaks a gematoplatsentarny barrier.
Indications to use
Naloxonum is appointed:
- at acute poisoning with narcotic analgetics (morphine, Promedolum, Ketaminum, halothane, buprenorphine, Fentanyl, pentazocine, nalbufiny, butorfanoly);
- for cancellation of such substances on an organism;
- in the absence of breath at newborns if their mothers before gave opioid analgetics;
- at an alcoholic coma;
- as a part of complex treatment of arterial hypotension at septic shock;
- for diagnosis of opioid dependence.
Medicine is contraindicated in the presence of an allergy to its components.
- spasms, excitement, tremor, irritability, fatigue;
- arrhythmia, problems with arterial pressure, tachycardia;
- nausea, vomiting;
- allergy, perspiration, fluid lungs, anesthesia termination.
Application instruction of Naloxonum (way and dosage)
The drug is administered intravenously, subcutaneously or intramusculary.
The application instruction of Naloxonum at overdose by opioids
The adult enter 400 mkg of drug, to children – 10 mkg on 1 kg of weight. If after introduction of the first dose of improvement did not come, it is possible to enter the same quantity of medicine in 2 minutes.
Anesthesiologists can appoint 100-200 mkg (for adults) intravenously, then as necessary it is possible to enter drug each 2-3 minutes, increasing a dosage by 100 mkg. Further the drug can be administered intramusculary.
In the absence of breath at newborns which was a vyzvanoa reception nark. analgetics at childbirth, appoint 0,1 mg to weight kg intramusculary, intravenously or subcutaneously. Then the preventive injection, a dosage – 0,2 mg intramusculary is possible.
For identification of existence of opioid dependence at the patient enter once of 0,8 mg of drug intravenously.
Data on overdose are absent.
Drug considerably blocks effects of various narcotic analgetics.
Terms of sale
Naloxonum is on sale according to the recipe.
Store drug in cool (15-25 degrees) the place, without access of direct sunshine.
Period of validity
At use for the patients suffering from dependence on opioid analgetics; received their earlier high dose; the children born from mother suffering from such dependence it is necessary to be careful.
Naloxonum is not effective at the respiratory depression caused by other medicines.
Use of medicine has to happen only under control of the specialist.
Drug with care is used at newborn children.
/a class='other-apteks-link link01'>to show still
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Naloxonum surely consult with the attending physician.