Sodium Chloride

Натрия Хлорид Drug photo

The description is actual on 03.08.2015

  • Latin name: Natrii chloridum
  • ATH code: B05XA03
  • Active ingredient: Sodium chloride (Sodium chloride)
  • Producer: Medical polymer, Synthesis of joint stock company, Alium Production pharmaceutical company (Russia), Farmlend of the joint venture (Republic of Belarus)

Structure

Acting making this means — sodium chloride. The sodium chloride formula – NaCl, is crystals of white color which are quickly dissolved in water. Molar weight is 58.44 g/mol. The OKPD code — 14.40.1.

Normal saline solution (isotonic) is a solution of 0,9%, it contains 9 g of sodium of chloride, to 1 l of the distilled water.

Hypertonic salt solution of sodium chloride is a solution of 10%, it contains 100 g of sodium chloride, to 1 l of the distilled water.

Release form

Solution of sodium of chloride of 0,9% which can contain in ampoules on 5 ml, 10 ml, 20 ml is made. Ampoules are applied for the purpose of dissolution of drugs to introduction of an injection.

Also solution of sodium of chloride of 0,9% in bottles with a capacity of 100, 200, 400 and 1000 ml is made. Their use practices in medicine for use outwardly, carrying out drop injections intravenously, carrying out enemas.

Solution of sodium of chloride of 10% contains in bottles with a capacity of 200 and 400 ml.

For the purpose of oral administration tablets on 0,9 g are issued.

Also nasal spray in bottles on 10 ml is made.

Pharmacological action

Sodium chloride is a drug which works as regidratiruyushchy and disintoxication means. Medicine is capable to compensate in an organism for the sodium deficiency on condition of development of various pathologies. Sodium chloride also increases amount of liquid which circulates in vessels.

Such properties at solution are shown thanks to existence in it chloride ions and sodium ions. They are capable to get through a membrane of cells by means of different transport mechanisms, in particular sodium potassium pump. Sodium plays an important role in the course of signaling in neurons, also it is involved in the course of a metabolism in kidneys and in electrophysiologic processes of heart of the person.

The pharmacopeia demonstrates that sodium chloride supports constant pressure in extracellular liquid and a blood plasma. At an organism normality enough this connection gets to an organism with food stuffs. But at morbid conditions, in particular, at vomiting, a diarrhea, serious burns the increased allocation from an organism of these elements is noted. As a result, the organism has deficiency of ions of chlorine and sodium owing to what blood becomes more dense, functions of a nervous system, a blood stream, spasms, spasms of smooth muscles of muscles are broken.

If isotonic solution of sodium of chloride is timely entered into blood, its use promotes recovery of water-salt balance. But as the osmotic pressure of solution similar to blood plasma pressure, in a vascular bed for a long time it is not late. After introduction he is quickly brought from an organism. As a result, in 1 hour in vessels no more than a half of the solution entered quantity is late. Therefore in case of blood loss solution is not rather effective.

Means also has plasma substituting, disintoxication properties.

At introduction of intravenously hypertonic salt solution diuresis strengthening, completion of deficit of chlorine and sodium in an organism is noted.

Pharmacokinetics and pharmacodynamics

Removal from an organism happens generally through kidneys. A little sodium is emitted with then and with a stake.

Indications to use

Sodium chloride is a physical solution which is applied in case of loss by an organism of extracellular liquid. It is shown at states which lead to restriction of intake of liquid:

  • dyspepsia at poisoning;
  • vomiting, diarrhea;
  • cholera;
  • extensive burns;
  • hyponatremia or hypochloraemia at which organism dehydration is noted.

Considering what is sodium chloride, it is applied outwardly for the purpose of washing of wounds, eyes, a nose. Drug is used for the purpose of moistening of bandagings, for inhalations, for the person.

Use of NaCl for carrying out an artificial diuresis at a lock, poisonings is shown, at internal bleedings (pulmonary, intestinal, gastric).

It is designated also in indications to use sodium chloride that this such means which is applied to cultivation and dissolution of drugs which are entered parenterally.

Contraindications

Use of solution at such diseases and states is contraindicated:

  • hypopotassemia, hyperchloremia, hypernatremia;
  • extracellular overhydratation, acidosis;
  • fluid lungs, wet brain;
  • acute left ventricular failure;
  • development of circulator disturbances at which there is a threat of wet brain and lungs;
  • purpose of high doses of GKS.

Carefully solution is appointed to people who have arterial hypertension, peripheral hypostases, dekompensirovanny chronic heart failure, a renal failure in a chronic form, a preeclampsia, and also those for whom other states at which there is a sodium delay in an organism are diagnosed.

If solution is applied as the dissolving means to other drugs, it is necessary to consider the existing contraindications.

Side effects

At use of sodium chloride the following states can develop:

  • overhydratation;
  • hypopotassemia;
  • acidosis.

If drug is used correctly, then development of side effects is improbable.

If NaCl solution of 0.9% is applied as basic solvent, then by-effects are defined by properties of drugs which get divorced solution.

At manifestation of any negative effects it is necessary to report about it to the specialist at once.

Application instruction of Sodium of Chloride (Way and dosage)

The instruction on physical solution (isotonic solution) provides its introduction intravenously and subcutaneously.

In most cases intravenous drop administration practices for what the dropper of Sodium chloride gets warm up to the temperature of 36-38 degrees. The volume which is entered to the patient depends on in what state the patient, and also from that amount of liquid which was lost by an organism. At the same time it is important to consider age of the person and his weight.

The average daily dose of drug — 500 ml, is entered solution with an average speed of 540 ml/h. If strong degree of intoxication is noted, then the maximum volume of medicine in days can make 3000 ml. If there is such need, it is possible to enter the volume of 500 ml at a speed of 70 thaws a minute.

To children the dose from 20 to 100 ml a day on 1 kg of weight is entered. The dosage depends on body weight, on age of the child. It is necessary to consider that at long use of this medicine it is necessary to control surely the level of electrolytes in plasma and urine.

To dissolve drugs which need to be entered kapelno from 50 to 250 ml of sodium of chloride on one dose of medicine are applied. Determination of features of introduction is carried out on the main medicine.

Introduction of hypertonic salt solution is carried out intravenously struyno.

If solution is applied for the purpose of immediate completion of deficit of ions of sodium and chlorine, 100 ml of solution are entered kapelno.

To carry out a rectal enema for defecation calling, enter 100 ml of 5% of solution, it is also possible to enter 3000 ml of isotonic solution for days.

Use of a hypertensive enema is slowly shown at renal and cardiac hypostases, the increased intracranial pressure and at a hypertension is carried out slowly, 10-30 ml are entered. It is impossible to carry out such enema at an erosion of a large intestine and inflammatory processes.

Purulent wounds carry out by solution agrees with that scheme which is appointed by the doctor. Compresses with NaCl put directly to a wound or other defeat on skin. Such compress promotes department of pus, death of pathogenic microorganisms.

Nasal spray is dug in in a nasal cavity after its clarification. To adult patients dig in two drops in each nostril, to children – on 1 drop. It is applied both to treatment, and to prevention for what drip solution for about 20 days.

Sodium chloride is applied to inhalations at catarrhal diseases. For this purpose solution is mixed with broncholitic drugs. Inhalation is carried out for ten minutes three times a day.

At emergency physical solution can be prepared in house conditions. For this purpose the full teaspoon of table salt needs to be stirred in one liter of boiled water. If necessary to prepare the solution defined quantity, for example, with salt weighing 50 g, it is necessary to take the corresponding measurements. Such solution can be applied locally, to use for enemas, rinsings, inhalations. However it is impossible to enter such solution intravenously at all or to use for processing of open wounds or eyes.

Overdose

At overdose the patient can sicken, suffer from vomiting and diarrhea, at him abdominal pains, fever, tachycardia can develop. Also at overdose indicators of arterial pressure can raise, develop a fluid lungs and peripheral hypostases, a renal failure, myotonia, weakness, dizziness, generalized spasms, a coma. At excessive administration of solution the hypernatremia can develop.

At excessive receipt giperkhlorimichesky acidosis can develop in an organism.

If sodium chloride is applied to dissolution of drugs, then generally overdose is connected with properties of those drugs which are exposed to cultivation.

At inadvertent excess introduction of NaCl it is important to stop this process and to estimate whether the patient has more negative symptoms. The symptomatic treatment practices.

Interaction

NaCl is combined with the majority of drugs. This its property causes use of solution for cultivation and dissolution of a number of drugs.

At cultivation and dissolution it is necessary to control compatibility of drugs visually, defining whether the deposit appears in process, whether color, etc. changes.

It is badly combined with noradrenaline.

At co-administration of drug with corticosteroids it is important to trace constantly the content of electrolytes in blood.

At parallel reception hypotensive effect of Enalapril and Spirapril goes down.

Chloride is incompatible with a leukopoiesis stimulator Filgrastimom, and also with a polypeptide antibiotic Polymyxin B of Sodium.

There are data that isotonic solution increases bioavailability of drugs.

At cultivation by solution of powdery antibiotics they are acquired by an organism completely.

Terms of sale

In drugstores is on sale according to the recipe. In need of use of drug for dilution of other drugs, etc. write out the recipe in Latin.

Storage conditions

To store powder, tablets and solution it is necessary in the dry place, in well corked container, at the same time temperature has to make no more than 25 degrees Celsius. It is important to protect drug from access for children. If packaging is tight, then freezing does not influence properties of drug.

Period of validity

For storage of powder and tablets of restrictions is not present. Solution can be stored in ampoules of 0,9% for 5 flyings; solution in bottles of 0,9% – one year, solution in bottles 10%– 2 years. It is impossible to use after period of storage came to the end.

Special instructions

If infusion is carried out, it is necessary to watch carefully a condition of the patient, in particular, behind blood plasma electrolytes. It is necessary to consider that at children in view of immaturity of function of kidneys delay of excretion of sodium is possible. It is important to define its concentration in plasma before carrying out repeated infusions.

It is important to control a condition of solution before its introduction. Solution has to be transparent, packaging – unimpaired. Only the qualified specialist can apply solution to intravenous administration.

Only the specialist who can competently estimate whether the received solution is suitable for introduction has to dissolve any drugs Chloride Sodium. It is important to maintain all rules of antiseptics strictly. Administration of any solution needs to be carried out at once after its preparation.

Result of a number of chemical changes with participation of sodium of chloride is formation of chlorine. Electrolysis of fusion of Sodium chloride in the industry – a way of receiving chlorine. If carried out Sodium chloride solution electrolysis, also as a result receive chlorine. If on crystal Sodium chloride worked the sulphuric acid concentrated as a result receive chlorohydrogen. Sodium sulfate and sodium hydroxide can be received by a chain of chemical changes. High-quality reaction to chloride an ion – reaction with silver nitrate.

Analogs

At different producers of medicines solution can be issued under the separate name. These are Natriya's drugs chloride Brown, Natriya chloride Bufus, Rizosin, Salin Natriya Sinko's chloride, etc.

Also the drugs containing sodium chloride in structure are made. These are the combined saline solutions of sodium acetate + sodium chloride, etc.

Zdravzona

  • Sodium chloride bufus solution of 0,9% 5 ml No. 10 ampulyobnovleny PFK of closed joint stock company
  • Sodium chloride of 0,9% 200 ml No. 24 fl. JSC Krasfarm
  • Sodium chloride of 0,9% 400 ml fl. No. 12krasfarma of joint stock company
  • Sodium chloride bufus solution of 0,9% 10 ml No. 10 ampulyobnovleny PFK of closed joint stock company
  • Sodium chloride of 0,9% solution for infusions of 200 ml No. 1 flakonmosfarm Ltd company

Drugstore of IFC

  • Sodium chloride solution for in 0.9% 10 ml No. 10, Groteks Ooorossiya
  • Sodium chloride solution for inf 0.9% 200 ml No. 28 *, Zaorossiya's Mosfarm
  • Sodium chloride solution for inf 0.9% 400 ml *, Zaorossiya's Mosfarm
  • Sodium chloride solution for in 0.9% 5 ml No. 10, Groteks Ooorossiya
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Apteka24

  • Sodium hloridyuriya-Farm (Ukraine, Kiev)
  • Sodium hloridyuriya-Farm (Ukraine, Kiev)
  • Sodium hloridgalichfarm (Ukraine, Lviv)
  • Sodium hloridfarmatreyd (Ukraine, Drogobych)
  • Sodium chloride

Paniapteka

  • Sodium chloride solution of 0.9% 1000mlfarmatreyd
  • Sodium chloride solution of 0.9% 1000mlfarmatreyd
  • Sodium chloride solution of 0.9% 1000mlfarmatreyd
  • Sodium chloride solution of 0.9% 1000mlfarmatreyd
  • Sodium chloride solution of 0.9% 1000mlfarmatreyd

BIOSPHERE

  • Sodium chloride of 0,9% 250 ml solution for inf.fl. Huashidan of joint stock company, applicant of ANP limited liability partnership, Kazakhstan (China)
  • Sodium chloride of 0,9% 400 ml solution for inf.fl.poliet. with nippelemniko Ltd company (Ukraine)
  • Sodium chloride of 0,9% 500 ml solution for inf.fl. Huashidan of joint stock company, applicant of ANP limited liability partnership, Kazakhstan (China)
  • Sodium chloride of 0,9% 200 ml solution for inf.fl.poliet. with nippelemniko Ltd company (Ukraine)
  • Sodium chloride of 0,9% 500 ml solution for inf.fl. Kelun pharmaceutical plant (China)
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Section: For blood
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Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before Sodium medicine use Chloride surely consult with the attending physician.