Neotone

Неотон Drug photo

The description is actual on 13.02.2015

  • Latin name: Neoton
  • ATH code: C01EB05
  • Active ingredient: Phosphocreatinine (Phosphocreatine)
  • Producer: Alpha Wasserman S. of the item. And. (Italy)

Structure

In 1 bottle of phosphocreatinine of sodium 1 of.

Release form

Lyophilisate in a bottle for solution preparation.

Pharmacological action

Cardioprotective, metabolic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active ingredient phosphocreatinine is of great importance in power providing the mechanism of reduction of muscles - it is a power reserve of muscle cells.

On structure it is similar to endogenous phosphocreatinine which is a carrier of energy and in a cell it is used for ATP synthesis at which hydrolysis energy necessary for actomyosin reduction is formed (the protein of muscle fibers providing their reduction). The shortcoming it is followed by reduction of force of reductions of a cardiac muscle even at enough ATP in a cell. At ischemia the content of phosphocreatinine in muscle cells quickly decreases.

Phosphocreatinine has cardioprotective effect as slows down destruction of a membrane of cardiomyocytes at ischemia, stimulates in them energy balance, improves a metabolism therefore the size of a zone of ischemia and a necrosis decreases. At ischemia and at recovery of a blood-groove in an infarktozavisimy artery has antiarrhytmic effect.

Pharmacokinetics

After infusion of Cmax in blood it is reached in 3 min. In the maximum quantity collects in a myocardium, skeletal muscles and a brain, in a small amount in a liver and lungs. Neotone is removed by kidneys.

Indications to use

  • cardiomyopathy of various genesis;
  • acute myocardial infarction;
  • the myocardium ischemia which arose during operation;
  • the ischemia of the lower extremities which arose during operation;
  • myocardiosclerosis;
  • chronic heart failure;
  • encephalopathies;
  • disturbance of cerebral circulation;
  • traumatic damages of TsNS;
  • Cerebral spastic infantile paralysis at children (in complex therapy);
  • improvement of adaptation of professional athletes to loadings;
  • prevention of a syndrome of a physical overstrain at athletes.

Contraindications

Neotone is not used at a chronic renal failure (in high doses) and at children. It is contraindicated at hypersensitivity to it.

Use of drug at pregnancy is allowed with big restrictions — if effect for mother more risk for a fruit.

Side effects

Neotone, application instruction (Way and dosage)

It is entered intravenously.

Acute myocardial infarction. Begin treatment with 2–4 g which are entered struyno, with transition to drop infusion — 8–16 g on 200 ml of normal saline solution, slowly during 2 h. On second day enter in/in kapelno 2–4 g 2 times. On third day in/in kapelno on 2 g twice. In such mode treatment is carried out 6 days.

HSN. In/in kapelno 1–2 g 2 times a day.

Prevention of intraoperative ischemia of a myocardium. Enter infusionally, adding 3 g of drug on liter of cardioplegic solution just before infusion. Preventively infusions on 2 g twice in 3 days prior to operation and 2 days after it are carried out.

Prevention of intraoperative ischemia of extremities. 8–10 g are entered into struyno 2–4 g before operation, then infusionally during operation.

The application instruction of Neoton does not contain recommendations about use of drug for athletes. However it is appointed as an energizator which allows to create "power depot", to improve sokratitelny ability of skeletal muscles and a cardiac muscle in 8-10 days prior to start. Administration of drug is carried out also to the recovery period — directly after the end of competitions.

Overdose

It is not registered. In case of lowering of arterial pressure vazokonstrivtor are appointed.

Interaction

Medicine Neoton increases efficiency of antiarrhythmic and anti-anginal means, and also the drugs increasing force of cordial reductions (Dobutaminum, Epinephrinum, Norepinephrinum, cordial gltkozida).

Drug is compatible and keeps stability in cardioplegic solutions, 5% to glucose, water for injections. On interaction with alcohol information is absent.

Terms of sale

According to the recipe.

Storage conditions

At a temperature no more than 300C.

Period of validity

3 years.

Analogs

Phosphocreatinine. Substitutes — ATP Long, Atf-Forte, Sodium Adenosinetriphosphate.

About Neotona

About Neotona mostly concern use him at aortocoronary shunting and ischemia of a brain. As at these diseases drug is used not in the form of monotherapy therefore it is impossible to draw a conclusion on its efficiency. However many athletes note its positive action and consider that without it it is impossible to achieve good results and that drug unfairly is a little used in sports medicine.

According to cardiosurgeons effect of use noticeable, especially at the stopped heart during aotrokoronarny shunting for prevention of ischemia. Experience of use of drug for newborns in the early postoperative period is described. Opinions on expediency of use of drug as cardiotrophic, as a part of basic therapy are expressed.

From side effects lowering of arterial pressure is noted.

Zdravzona

  • Neotone of 1 g powder for Preeg. solution for infusions No. 1 a bottle
  • Neotone of 1 g powder for Preeg. solution for infusions No. 4 bottles
  • ISISPHARMA Neoton Redians cream SPF50+ 30 of ml (Neotone Radiance), day against a nevus pigmentosus, Isis of Farm
  • ISISPHARMA Neoton serum Isis bleaching 25 ml (Neotone) of Farm
  • Neotone serum Isis bleaching night 25 ml (Neotone) of Farm

Drugstore of IFC

  • Neotone serum of bleaching night 25 ml, ISIS Pharmashveytsariya
  • Neotone redians cream SPF50+ 30 of ml, day from a nevus pigmentosus, ISIS Pharmashveytsariya
  • Neotone por.d/inf 1 g fl No. 4 (without solvent), Alfa-Wassermannitaliya
  • Neotone + Yuniton set of syv.otbel.nochny 25 ml + gel otshel.150ml, ISIS Pharmashveytsariya
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Apteka24

  • Neotonalfa Wassermann (Italy)
  • Neotone liof. time. 1 g No. 4 Alpha Wasserman (Italy)

BIOSPHERE

  • Neotone of 1 g No. 4 por.liof.d/inf.alfa Wassermann (Italy)
  • Neotone of 1 g No. 1 por.liof.d/inf.alfa Wassermann (Italy)
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Section: Cardiological
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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