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Drug includes active agents: ascorbic acid – 175 mg, thiamin nitrate – 50 mg, Riboflavinum – 25 mg, calcium pantothenate – 25 mg, a pyridoxine a hydrochloride – 10 mg, folic acid – 500 mkg, cyanocobalamine – 5 mkg, nikotinamid – 100 mg.
Additional components: potato starch, magnesium stearate, silicon dioxide colloid anhydrous, talc and calcium hydrophosphate.
The body and lid of a capsule consist from: FD&CА Red 3 dye, D&C Yellow 10 dye, gelatin, titanium dioxide (E171).
Neurobeks Neo in the gelatinous capsules, orange-black color containing powder is issued. Packaging includes about 30 or 60 pieces.
Neurobeks is Neo the combined polyvitaminic drug containing ascorbic acid and vitamins of group B.
Pharmacodynamics and pharmacokinetics
Effect of drug is caused by properties of the vitamins which are its part.
After reception of capsules one of active components (thiamin) is phosphorylated therefore cocarboxylase is formed. This substance is a coenzyme which is a participant of many fermental reactions. Thiamin is required at carbohydrate, proteinaceous and a lipometabolism, carrying out nervous impulses in synapses. Insufficiency of this substance results in excessive concentration of milk and pyroracemic acids which can cause development of polyneurites, Vernike's encephalopathy, Korsakov's syndrome, disturbances of functions of heart, a gastrointestinal tract and another.
The pyridoxine actively supports functions of a nervous system. As a result of phosphorylation the coenzyme which is necessary for a full-fledged metabolism of the amino acids and other enzymes which are in nervous tissues is formed of B6 vitamin. Besides, the pyridoxine participates in process of biosynthesis of neuromediators: histamine, noradrenaline, adrenaline, serotonin, gamma aminobutirovoy acids. The hyponutrient, disturbance of the gastrointestinal tract functions, use of a number of medicines which concern to his antagonists can cause deficit of B6 vitamin. It can lead to development of a glossitis, stomatitis, a convulsive state, peripheral neuritis, anemia and other disturbances.
Cyanocobalamine promotes a normal hemopoiesis, maturing of erythrocytes and the course of the biochemical reactions providing full life activity of an organism: production of nucleic acids, protein, transportation of methyl groups, exchange processes of amino acids, carbohydrates and lipids. It is established that this substance exerts positive impact on work of a nervous system, development and replication of cells. The lack of B12 vitamin is shown by the disturbances of work of a hemopoietic and nervous system causing serious complications.
Riboflavinum is the major catalyst in processes of visual perception and cellular respiration. After intake interaction of Riboflavinum and ATP therefore flavin adeninenucleotide and flavin mononucleotide are formed is noted. These substances belong to coenzymes which transfer hydrogen and regulate oxidation-reduction processes. Participation of Riboflavinum in processes proteinaceous, carbohydrate and a lipometabolism, maintenance of full visual function and synthesis of hemoglobin is also noted. The lack of B2 vitamin can cause a hyporiboflavinosis, and in an effect and an ariboflavinosis. At a hyporiboflavinosis appetite goes down, weight decreases, weakness, headaches, burning of integuments, gripes of eyes, disturbance of twilight sight, painful feelings in corners or an under lip develops. Further development of a disease is followed by cracks or crusts on lips in the form of angular stomatitis, dryness and reddening of language, seborrheal dermatitis in the field of nasolabial folds, emergence of a photophobia, conjunctivitis, a blepharitis. Increase of secretory function of a stomach, strengthening of a zhelchevydeleniye, simplification of absorption of carbohydrates in a small intestine is also possible.
Nikotinamid is necessary for tissue respiration, a metabolism of fats, carbohydrates and amino acids.
Calcium pantothenate is one of components of coenzyme A which participates in acetylation and oxidation of fats and carbohydrates, production of bile acids and hormones.
Folic acid is important for implementation of full synthesis of erythrocytes, a metabolism of carbohydrates, division and development of cells. At a lack of folic acid braking of transition of a megaloblastichesky phase of a hemopoiesis in normoblastic is noted that causes megaloblastny anemia.
Ascorbic acid is the regulator of oxidation-reduction processes participating in synthesis of collagen, catecholamines, steroid hormones and a metabolism of folic acid. This substance is necessary during the forming of bones and teeth, assimilation by an organism of useful components, for example: gland, beta karotena, calcium and vitamin E. The importance of vitamin C in the course of regulation of coagulability of blood, stimulation of a hemopoiesis, permeability of vessels is noted. Besides, ascorbic acid is the strongest antioxidant weakening action of free radicals which lead to injury of healthy cells. Also resistance of an organism to influence of external adverse factors, body resistance to viral and bacterial infections increases. Concentration of a histamine which is an inflammation mediator thanks to what cold symptoms – rhinitis, dacryagogue, reddening of a conjunctiva are softened decreases. Vitamin C promotes increase of intellectual and physical effeciency, activation of standard metabolisms.
All components which are a part of Neurobeks Neo are water-soluble vitamins therefore their cumulation in an organism is excluded.
Absorption of thiamin and pyridoxine occurs in upper part of intestines then hypodispersion in an organism is noted them. At the same time extent of absorption has direct dependence on a dosage. Process of absorption of cyanocobalamine is defined by existence of an internal factor in upper part of intestines and a stomach. Delivery of substance in fabric transcobalamine II carries out transport protein.
As a result of fast and easy absorption Riboflavinum is distributed in an organism rather unevenly – the most part is noted in a myocardium, kidneys and a liver.
Absorption of folic acid happens in the form of simple hydrolyzates. The insignificant part of the enzymes which are carrying out hydrolysis are located in a 12-pyorstny and small bowel. Substance gets practically into all body tissues. At the same time a third of substance in the form of methylfolate is in a liver.
Fast absorption of a nikotinamid comes from a gastrointestinal tract, and then substance is evenly distributed in fabrics and bodies.
Fast absorption in intestines is characteristic of ascorbic acid. Then circulation of vitamin C is noted as a part of a blood plasma, and concentration in ferruterous fabric. At the same time the main concentration of substance is found in fabrics, thrombocytes and lymphocytes.
Calcium pantothenate is also easily and quickly soaked up from a gastrointestinal tract then concentrates in heart, kidneys and a liver.
The metabolism of thiamin, pyridoxine and cyanocobalamine is carried out in a liver. Process of a metabolism and biotransformation of folic acid are completely not studied. The metabolism of a nikotinamid occurs in the form of methylation therefore inactive metabolites are formed. At a metabolism of ascorbic acid oxalic acid and other water-soluble metabolites is formed.
Removal of this drug happens practically through all bodies of secretory system. The pyridoxine and thiamin are removed by means of kidneys, at reception of high doses – through intestines. Removal of cyanocobalamine happens mainly to bile, Riboflavinum, a nikotinamid, ascorbic acid and calcium of pantothenate – to urine in an invariable look or in the form of metabolites.
Indications to use
Neurobeks Neo is appointed in a combination therapy of various states and diseases:
- asthenic syndrome, syndrome of chronic fatigue, stress, vegeto-vascular dystonia, encephalopathy, osteochondrosis, neuritis, polyneuritis, flaccid paralysis, radiculitis, lumbago, sciatica, neuralgia, spastic conditions of the central genesis, myasthenia, traumatic defeats of TsNS;
- hepatitis, cirrhosis, chronic pancreatitis, disturbances of the gastrointestinal tract functions;
- chronic circulatory unefficiency, myocarditis, myocardial dystrophy, the recovery period after the postponed cardiovascular diseases;
- diabetes mellitus and its complications, diseases of a thyroid gland;
- neurodermatitis, eczema, eels, dermatitis of various genesis, shingles;
- disturbances of blood circulation in a retina, a myopia, an astigmatism, an amblyopia, glaucoma, a diabetic retinopathy, a makulodistrofiya, an optic neuritis, a cataract;
- disturbances of a menstrual cycle, mastopathies, conservative therapy of a hysteromyoma, salpingo-oophoritis, endometritis;
- the lowered immunity, acute infectious diseases;
- neuritis of an acoustical nerve, sensonevralny relative deafness, labyrinthopathy;
- during the antibiotic therapy suppressing gram-negative flora of intestines;
- chronic diseases, at advanced age, at alcohol intake or tobacco.
Contraindications to use
It is necessary to refrain from use of Neurobeks Neo at:
- acute thromboembolism;
- hyperglobulia and erythremia;
- children's age less than 12 years;
- high sensitivity to its components.
The instruction to Neurobeks Neo (A way and a dosage)
As the application instruction of Neurobeks Neo shows, daily appoint on one capsule. During treatment of neurologic disturbances the dosage of drug can be doubled. The therapeutic course makes 2-4 weeks.
In overdose cases patients feel nervous excitement, heartaches, development of tachycardia.
Simultaneous use of Neurobeks Neo with a levodopa can lead to lowering of its protivoparkinsonichesky efficiency.
At prolonged treatment deficit of thiamin arises anticonvulsants – phenobarbital, Phenytoinum and carbamazepine in a combination with Neurobeks Neo quite often.
Terms of sale
Drug is released without recipe.
Storage of capsules requires the dark, dry place unavailable to children, with a temperature up to 30 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
Combined use of Neurobeks Neo and ethanol can sharply lower thiamin absorption, to level as a part of blood of 30%.
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