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The neuroruby is let out in the form of tablets, and also the solution intended for pricks (injections). In chemical composition of one ampoule of drug, with a nominal volume of 3 ml. about 100 mg contain. thiamin hydrochloride (B1 vitamin) and pyridoxine (B6), and also 1 mg. cyanocobalamine (B12).
One tablet of Neyrorubin contains 200 mg. mononitrate of thiamin, 50 mg. pyridoxine hydrochloride, and also 1 mg. cyanocobalamine.
200 mg are a part of a tablet of Neyrorubin Forte Laktab. mononitrate of thiamin, 50 mg. pyridoxine hydrochloride, and also 1 mg. cyanocobalamine.
Besides, as a part of drug there are such auxiliary connections as: powdery cellulose, gipromelloza, prezhelatinizirovanny starch, Mannitolum, microcrystallic cellulose, magnesium stearate, and also colloid silicon dioxide.
The film cover of a tablet contains titanium dioxide, a macrogoal 6000, erythrosine, talc and a gipromelloza.
Neyrorubin's tablets in a film cover package 10 pieces in blisters. As a rule, one cardboard packaging contains 2 blisters.
Solution in ampoules, with a nominal volume of 3 ml., pack into cardboard boxes 5 pieces in everyone.
Tablets to Neyrorubin Forta Laktab pack into planimetric blisters 10 pieces in everyone and place in cardboard packagings.
Drug belongs to the medicines containing a complex of vitamins in the structure. To Neyrorubin and Neyrorubin Forta Laktab contain in the structure the neurotropic vitamins relating to group B which play an important role in a metabolism of carbohydrates, proteins and fats, and also participate in exchange processes.
Pharmacodynamics and pharmacokinetics
Complex of vitamins Neyrorubin contains in the structure water-soluble B1, B6 vitamins, and also B12. Despite belonging of these vitamin connections to the same group of useful substances, all of them differ in the wide range of biological activity. Besides, each vitamin is responsible for the different processes happening in a human body.
B1 vitamin, for example, takes active part in a metabolism of carbohydrates, fats, but also proteins. At deficit of thiamin in a human body the level of pyroracemic, and also lactic acid increases. Thanks to useful connection there is a process of transamination and deamination of irreplaceable amino acids.
Thus B1 vitamin normalizes protein metabolism. It should be noted that this substance acts as the catalyst in the course of a metabolism of fats and formation of fatty acids, stimulates secretory function of intestines and a peristaltics, and also interacts with cellular membranes in neurons and activates ion channels.
Vitamin B6 as well as B1 takes active part in a metabolism of proteins and fats, and also in synthesis of enzymes. This connection, useful to a human body, acts as a coenzyme in fermentalny reactions. The pyridoxine promotes formation of a neural myelin membrane, and also takes part in a protein and lipidic metabolism, synthesis of hemoglobin and neuromediators in synapses of a peripheral and central nervous system.
B12 vitamin plays an important role in protein metabolism, and also regulates production of nucleic acids, purines, but also amino acids. Such connection as cyanocobalamine it is vital for an organism as substance exerts impact on development of acetylcholine, and also on the course of myelination of neurons. To all other this vitamin connection positively influences regeneration of nerve fibrils, and also stimulates peripheral nervous structures on development of impulses.
Substance renders hemopoietic effect on a human body, regulates cholesterol level, and also stimulates an erythrogenesis. B12 vitamin promotes improvement of a hemopoiesis and normalizes blood coagulation speed. Everything in total B1, B6 and B12 vitamins contribute to normalization of work of a nervous system of the person, but also, exert positive impact on protein, lipidic, fatty and carbohydrate metabolism.
It should be noted as well that this combination of vitamin connections considerably facilitates pain at neurologic diseases of various genesis. Neyrorubin's pharmacokinetics directly depends on distinctive properties of the vitamin connections which are a part of medicine.
After administration of drug in intestines, lean and a duodenum there is a thiamin absorption. The insignificant amount of B1 vitamin is acquired by a liver, then useful substance is metabolized and breaks up to pyramine, and also thiamin-carboxylic acid. Thiamin is removed from an organism by means of kidneys and intestines, and both in an invariable look, and as metabolites.
The hydrochloride of a pyridoxine is absorbed in intestines, and then metabolized in an organism and breaks up to pyridoxamine, the piridoksal-5-phosphate which is carrying out a role of coenzyme and piridoksal (active metabolites of vitamin connection).
B6 vitamin is characterized by the close connection with the proteins which are contained in a blood plasma. Connection kumulirutsya in muscles, a liver, and also in bodies of a nervous system. The pyridoxine is brought out of an organism on means of kidneys also as well as thiamin (B1) in invariable structure or in the form of active metabolites.
At normal absorption of B12 vitamin, useful connection is metabolized and will be transformed in adenozilkobalamin. Connection to be removed through bile and urine, and also kumulirutsya in a liver.
Indications to use
First of all the tableted forms of such drugs as to Neyrorubin and Neyrorubin Forta Laktab use as a prophylactic at states of which the vitamin deficiency of group B, and also as a part of complex therapy at treatment such diseases as is characteristic:
Solution for injections Neyrorubin is used as separate monotherapeutic means, and also as a part of complex therapeutic treatment of such diseases as:
- diabetic polyneuropathy;
- beriberi illness (not very well wet or dry form of a disease);
- neuritis, including acute and chronic forms of a disease;
Both drugs are contraindicated at the following diseases:
- diathesis is allergic;
- lactation period;
- hypersensitivity to chemical composition of drugs;
- age till 18 flyings.
At Neyrorubin Forte's reception and Neyrorubin Forta Laktab there can be following side effects of drugs:
- increase in blood of level hepatic transmiaz;
- gastric bleedings;
- causeless concern;
- feeling of alarm;
- touch neuropathy;
- the collapse is circulator;
- fluid lungs;
- skin itch;
- development of acne rash;
- small tortoiseshell;
- rash on integuments;
- the increased sweating;
- Quincke's edema;
- acute anaphylaxis.
The instruction on Neyrorubin (A way and a dosage)
Drug dosage, as well as duration of a course of therapeutic treatment, the doctor defines, relying on character of a disease, and also a condition of the patient. According to the instruction on Neyrorubin Forta, a pill is taken later, to or during meal, and without chewing and washing down with water, it is desirable boiled and room temperature.
For adult patients the average therapeutic dose of drug in 1-2 tablets a day is established. As a rule, the course of treatment Neyrorubin averages one month.
According to the application instruction of Neyrorubin, injections are given to remove a pain syndrome depending on disease severity every day or once in two days. Solution in ampoules is entered intramusculary into gluteuses. When the condition of the patient improves, for maintenance of medicinal effect it is recommended to enter intramusculary on 3 ml. A neuroruby few times in a week.
As a rule, at overdose by drug at patients side effects become aggravated. Carrying out a gastric lavage is in this situation shown to the patient, and also symptomatic therapy.
Neyrorubin, the Levodopa and Altretamin as the vitamin complex reduces efficiency of the above-stated medicines is not recommended to accept jointly. In order to avoid strengthening of toxicity of the Isoniazid it is not necessary to use at the same time this drug and a complex of vitamins of group B.
It is worth remembering that antagonists of B1 vitamin are such substances as Fluorouratsil, and also thiosemicarbazone. Neyrorubin Forte Laktab's absorption is reduced by the drugs possessing antiacid properties and rendering the enveloping effect.
Terms of sale
To store in the place unavailable to children, at a temperature which is not exceeding 25 °C.
Period of validity
Extra care the vitamin complex should be accepted to the patients having heart failure, and also stenocardia. Extremely seldom, however, happens at long drug intake that high daily dosages of drug cause development of a touch neuropathy which disappears right after the termination of use of Neyrorubin in patients.
In time drug intake it is necessary to be careful when driving or during the work with potentially dangerous mechanisms as drug causes such side effects as weakness, dizziness and causeless concern, and also alarm.
It is possible to distinguish the following drugs from analogs of this vitamin complex:
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