Nifuratel

Нифурател Constitutional formula

The description is actual on 26.02.2016

  • Latin name: Nifuratelum
  • ATH code: G01AX05
  • Chemical formula: C10H11N3O5S
  • CAS code: 4936-47-4

Chemical name

5-[(Metiltio) was marked]-3-[[by (5-nitro-2-фуранил) methylene] amine] - 2-oksazolidinon

Chemical properties

Nifuratel – the anti-inflammatory, antibacterial agent derivative of nitrofuran. The molecular mass of a chemical compound = 285,3 grams on mol. Substance is let out in the form of tablets for intake, Nifuratel is a part of candles and ointments for local use.

Pharmacological action

Antifungal, antibacterial, antiprotozoan.

Pharmacodynamics and pharmacokinetics

Nifuratel – antibacterial agent of a broad spectrum of activity. Drug is active concerning gram-positive and gram-negative microorganisms: stafilokokk, Citrobacter spp., Enterococcus faecium, salmonellas, Escherichia coli, klebsiyella, Enterococcus faecalis, Bacillus subtilis, Shigella flexneri, Enterobacter spp., Shigella sonnei, Serratia spp., Morganella spp., Pragia fontium, Rachnella aquatilis; lyambliya and protozoa; Rettgerella spp., Budvicia aquatica, Acinetobacter spp.; sort mushrooms Candida and Trichomonas vaginalis.

Medicine is less active in relation to Pseudomonas aeruginos, Proteus mirabilis and Proteus vulgaris.

Substance is rather effective at trichomoniasis, perniciously influences the fungal and antibacterial flora accompanying a disease. Symptoms of a vaginitis pass quickly. Also means is effective at treatment of the damages of a gastrointestinal tract caused by a bacterium of Helicobacter pylori steady against effect of metronidazole.

After hit of a tablet in a digestive tract, active ingredient it is quickly and almost completely soaked up through stomach walls. Drug breaks a blood-brain barrier, is emitted with breast milk. The metabolism proceeds in tissues of a liver and muscular tissue. Medicine by means of kidneys is removed. About 30-50% of substance are excreted in not changed look.

Indications to use

By means of antibacterial agent the diseases caused by microorganisms, sensitive to effect of substance, treat:

  • vulvovaginitis, trichomoniasis;
  • infections of the urinogenital sphere, cystitis, pyelonephritis, urethritis, pyelitis;
  • the lambliasis, gastroduodenit, the coloenteritis, an amebiasis, holetsistopankreatit;
  • chronic diseases of the upper parts of a digestive tract caused by a bacterium Helikobakter.

Contraindications

Means is contraindicated at an allergy to active ingredient. It is necessary to be careful to pregnant women and during a lactation.

Side effects

Usually drug does not cause any significant side effects. Nevertheless, can be shown:

  • nausea, diarrhea, bitterness in an oral cavity, vomiting;
  • heartburn, gastralgia;
  • allergic enanthesis, itch.

Nifuratel, application instruction (Way and dosage)

Drug is appointed inside. Depending on a disease a dosage and the scheme of treatment various.

The instruction on Nifuratel

Standard daily dosage for the adult – from 600 mg to 1,2 g. The quantity of medicine which the child needs to accept within a day is calculated by the principle of 10-30 mg on weight kg.

Duration of treatment and frequency of reception depends on indications and is defined by the attending physician.

Other dosage forms (candles and ointment) use according to recommendations of the producer.

Overdose

There are no data on overdose by drug.

Interaction

At Nifuratel's combination to nystatin the antimicrobic effect of the last amplifies.

Simultaneous use of drug and tenonitrozol leads to strengthening of antitrikhomonozny effect of both means.

Terms of sale

The recipe from the doctor can be required.

Storage conditions

Tablets store far from small children, at a temperature not higher than 30 degrees.

Period of validity

5 years.

Special instructions

During treatment of vaginal infections it is recommended to carry out in parallel local therapy by other antibacterial agents.

Throughout passing of a rate of drug it is recommended to abstain from sexual contacts. It is also necessary to treat the sexual partner as prevention.

To children

Appoint according to direct indications and the recommendation of the doctor. It is necessary to correct a dosage.

Nifuratel's analogs: Makmiror, Nifuratel of a tablet, Makmiror Kompleks of a candle and cream (in a combination with nystatin).

Responses

About treatment by antibacterial agent good. Most often it is used at a vaginitis, sometimes during pregnancy. Side reactions develop seldom, most often they are connected with medicine which is taken in addition. In general patients who adhered to recommendations of the attending physician, happy result.

Nifuratel's price where to buy

The price of tablets Nifuratel in the form of drug Makmiror makes about 790 rubles, for 20 tablets on 200 mg. The price of candles Nifuratel (Makmiror Kompleks) – about 800 rubles for 8 pieces, on 500 mg.

Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance use Nifuratel surely consult with the attending physician.