Нитроминт Drug photo

The description is actual on 26.05.2015

  • Latin name: NITROMINT®
  • ATH code: C01DA02
  • Active ingredient: Nitroglycerine (Nitroglycerinum)
  • Producer: CJSC EGIS Pharmaceutical Plant (Hungary)


1 dose — nitroglycerine in the form of solution of 0,04 g.

Ethanol (96%), propylene glycol — as excipients.

Release form

The dosed aerosol in a cylinder with a single dose of 0,4 mg. In the cylinder supplied with the doser - the sprayer, 10 g of solution that corresponds to 180 doses. Does not contain freon.

Pharmacological action

Vazodilatiruyushchy, anti-anginal.

Pharmacodynamics and pharmacokinetics


Nitroglycerine — nitrogen-containing connection, a peripheral vazodilatator with venodilatiruyushchy and anti-anginal action.

Effect of nitroglycerine is connected with ability to release nitrogen oxide which influences an endothelium, causing relaxation of unstriated muscles and vasodilatation. Therefore preloading (venous return) and an afterload (vascular resistance of a big circle) decreases. Load of heart decreases oxygen requirement isnizhatsya.

Simultaneous expansion of coronary vessels significantly increases delivery of oxygen to a cardiac muscle. Decrease in venous return attracts pressure decrease in a small circle, reduction of volume of a left ventricle also eliminates a fluid lungs.

Weakens unstriated muscles of a gall bladder and channels, bronchial tubes, urinary tract, intestines. Effect of drug begins in 30-60 sec. and lasts from 10 to 30 min.


The aerosol is quickly soaked up from an oral cavity. Bioavailability of 100%. Cmax in blood is defined in 4 min. For 60% contacts blood proteins. Contacts erythrocytes.

It is metabolized with formation of mononitrates and dinitrates. Metabolites it is removed by kidneys. T1/2 makes 2,5–4,5 min.

Indications to use

  • stenocardia (stopping and prevention of attacks);
  • acute left ventricular failure (auxiliary treatment).


  • shock;
  • kollaptoidny states;
  • hypersensitivity to nitrates;
  • age till 18 flyings.

With care it is appointed at orthostatic hypotension, the acute circulatory unefficiency with the ABP is lower than 90 has some., the hypertrophic cardiomyopathy, a hemorrhagic stroke expressed to a renal and liver failure, anemia, epilepsy, an acute myocardial infarction with a low degree of admission of a left ventricle, a thyrotoxicosis, alcoholism, ChMT, closed-angle glaucoma, migraine.

Side effects

The aerosol can cause Nitromintum:

  • headache, tachycardia, decrease in the ABP, dizziness, feeling of heat, tsianozortostatichesky collapse;
  • weakness, block, feeling of alarm;
  • dryness in a mouth, nausea, an abdominal pain;
  • itch, skin rash;
  • burning under language, reddening mucous in the place of use;
  • sight illegibility;
  • methemoglobinemia.

Application instruction of Nitromintum (Way and dosage)

Drug is sprayed under language in time by breath holdings. Before the first use it is necessary to fill the pump with pressing the valve before emergence of an aerosol. If the cylinder is not often used, then it is necessary to fill the pump repeatedly.

The cylinder when spraying drug is held vertically, a head up. One pressing the valve corresponds to 1 dose — 0,4 mg of nitroglycerine. Before the use to stir up a cylinder there is no need.

Aerosol Nitromintum, application instruction

At a stenocardia attack spray is sprayed in number of 1–2 doses (0,4–0,8 mg) in a sitting position, with intervals of 30 pages. Then it is necessary to close a mouth. Repeated introduction — to 3 doses in 15 min.

For prevention of an attack 1 dose in 10 min. prior to loading is used.

At a fluid lungs and a left ventricular failure apply 4 doses more for a short time, controlling the ABP (systolic> of 100 mm of mercury.).

At elderly people the mode of dosing does not change.


Overdose is shown by symptoms: orthostatic hypotension, headache, sharp decrease in the ABP, tachycardia, dizziness, vomiting, drowsiness, face reddening, feeling of heat.

At reception of high doses (20 mg/kg and more) the methemoglobinemia, dispnoe, cyanosis, a collapse develops. Treatment: to lay the patient, having given to legs the raised situation. In hard cases — introduction of noradrenaline, completion of OTsK. It is contraindicated to apply Epinephrinum.


Vazodilatatora, APF inhibitors, beta adrenoblockers, BKK, neuroleptics, antidepressants, MAO inhibitors, Prokainamid and inhibitors of phosphodiesterase strengthen hypotensive effect of drug.

The concomitant use of AZZ, ethanol strengthens the vasodilating effect.

Nitromintum strengthens action of anti-adrenergic means of Digidroergotamin and reduces effects of Heparin.

Terms of sale

Without recipe.

Storage conditions

At a temperature from 15 to 25 °C.

Period of validity

3 years.


In pharmacy chain nitroglycerine drugs in tablets (usual and prolonged), in the form of spray, an aerosol, ointment, transdermalny plasters and films for gluing on a gingiva are widely provided: Nitroglycerine, Sustac, Sustonit, Nitrongum, Nitroderm, Glyukonit, Deponit 10, Nitrokor, Nirmin, Nit-ret, Perlinganit, Trinitrolongum, Nitradisk, Nitrosprey-ICN, Nitrospry, Nitro, Nitrosprint.


Nitroglycerine in the form of tablets in critical situation can not give the necessary effect. If to compare to sublingual tablets, then use of an aerosol is more effective — the beginning of action, more expressed anti-anginal action accelerates and stenocardia attack duration is reduced. In this connection, drug in these odds of release is suitable for rendering "ambulance". A number of patients give preference to an aerosol form in view of convenience of its use.

Negative responses which are connected with existence of side reactions meet. Spray Nitromintum, as well as all nitrates, causes a headache of the pulsing character and lasting of 15 minutes till several o'clock at certain patients. At elderly patients it is followed by dizziness. Developing of a headache is noted after the first administrations of drug. More often she is marked out when using drugs of long action.

For the purpose of reduction of this by-effect it is recommended to use jointly drugs with menthol (for example, Validol) or NPVS (Acetylsalicylic acid, Paracetamol). Much less often such side reactions as heartburn, nausea and vomiting meet.


  • Nitromintum 0,4mg/dose an aerosol hypoglossal dosed 180 doses 10gegis

Drugstore of IFC

  • Nitromintum aer 400mkg/dose 180 doses of 10 g, Egisvengriya
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  • Nitromintegis (Hungary)


  • Nitromintum of 0,4 mg / dose of 10 g aeroz.oral.doz. Egis Pharmaceutical plant of joint stock company (Hungary)
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Section: Cardiological Cardiovascular
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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