Noflyuks

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The description is actual on 12.07.2016

  • Latin name: Noflux
  • ATH code: A02BC04
  • Active ingredient: Rabeprazol (Rabeprazolum)
  • Producer: EGIS Pharmaceuticals PLC (Hungary)

Structure

Rabeprazol of sodium, magnesium oxide, Mannitolum, a hypro rod, magnesium stearate, the low-substituted hypro rod, ethyl cellulose, gipromelloza phthalate, iron oxide yellow, titanium dioxide, dibutilsebakat, talc.

Release form

Mg tablets 10, 20 in a kishechnorastvorimy cover, a round form, biconvex, yellow color in the blister on 7 pieces in cardboard packaging No. 14, 28.

Pharmacological action

Antiulcerous.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug belongs to HP group — inhibitors of the protonew pump, possesses antiulcerous action. It Biotransformirutsya in covering cells of a stomach to sulphonamide derivatives which suppress sulphhydryl groups, blocking a closing stage of production of hydrochloric acid and suppresses secretion process (basal and stimulated), irrespective of a type of an irritant. Drug highly lipofilen, quickly gets and concentrates in covering cells of a stomach, increases secretion of a hydrocarbonate and has cytoprotective effect.

Anti-secretory action is shown a current of one hour after administration of drug and reaches the maximum in 3 hours. After the termination of reception of Noflyuks normalization of secretory function happens in 2-3 days. Does not exert impact on respiratory, cardiovascular systems and TsNS.

Pharmacokinetics

Drug is completely absorbed from a gastrointestinal tract, peak concentration in blood are reached in four hours after its reception. Bioavailability makes about 52% (at oral administration). Extent of linkng with blood proteins — about 97%. It is removed with urine in the form of the metabolites possessing various pharmacological activity and in insignificant quantities — with a stake.

Indications to use

Tablets in a dosage of 10 mg

Treatment of displays of the dyspepsia caused by a hyperoxemia of a gastric juice.

Tablets in a dosage of 20 mg

  • Aggravations of a peptic ulcer of a stomach, ulcer of an anastomosis, duodenum ulcer;
  • gastroesophageal reflux disease in various forms (erosive, ulcer);
  • Zollinger's syndrome;
  • in complex treatment of patients with a peptic ulcer of a stomach for Helicobacter pylori inactivation.

Contraindications

High sensitivity to drug, age till 12 flyings, the lactation period, pregnancy, the expressed renal failure.

Side effects

Local allergic reactions, leukocytosis, thrombocytopenia, leukopenia, sleeplessness, weakness, headache, drowsiness, dizziness, pharyngitis, cough, rhinitis, nausea, vomiting, diarrhea, abdominal pains, meteorism, locks, adynamy, the increased sweating, arthralgias, mialgiya, oznoba, fever.

Noflyuks, application instruction (Way and dosage)

Pill is taken inside, swallowed without chewing, are not recommended to crush. The recommended dose at stomach ulcer of a 12-perstny gut makes 20 mg once a day, in the morning. Duration of treatment of 1 — 1,5 month, but according to indications terms can be increased.

At Zollinger's syndrome the initial dose makes 60 mg. All dose is accepted at one time. According to indications the dose can be increased to 120 mg a day, divided into 2 receptions on 60 mg. Duration of treatment is defined by clinical need.

Overdose

Data are absent.

Interaction

The concomitant use of drug with atanazaviry as effects of an atanazavir considerably decrease is not recommended. Joint reception from sodium ketokonazoly increases risk of considerable decrease in concentration in blood of antifungal drugs. Drug of Noflyuks slows down process of removal of HP which biotransformation occurs by a microsomal oxidation (anticoagulants, diazepam, Phenytoinum).

Terms of sale

Prescription sale.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years.

Noflyuks's analogs

Beret, Vero-rabeprazol, Zulbeks, Zolispan, Pariyet, Ontaym, Rabelok, Rabeprazol, Hayrabezol and others.

About Noflyuks

In most cases patients speak of drug favorably, note its high performance. "… Drug began to accept after Omeprazol who practically did not help me. Stomach aches proceeded. Noflyuks's use within several days practically put me on legs. There passed nearly six months, and there is no recurrence yet though earlier in the fall and in the spring always there came the aggravation of a peptic ulcer".

Zdravzona

  • Noflyuks 20 mg No. 14 of a tablet p/olaboratoires Liconsa/Egis
  • Noflyuks 10 mg No. 14 of a tablet p/olaboratoires Liconsa/Egis
  • Noflyuks 20 mg No. 28 of a tablet p/olaboratoires Liconsa/Egis
  • Noflyuks 10 mg No. 28 of a tablet p/olaboratoires Liconsa/Egis

Drugstore of IFC

  • Noflyuks tbl p / about kishechnorast. 20 mg No. 14, Egisvengriya
  • Noflyuks tbl p / about kishechnorast. 10 mg No. 14, Egisvengriya
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Section: Gastrointestinal
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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