Novinet

Новинет Drug photo

The description is actual on 01.06.2015

  • Latin name: Novynette
  • ATH code: G03AA09
  • Active ingredient: Dezogestrel (Desogoestrelum) + Ethinylestradiol (Aethinyloestradiolum)
  • Producer: Gedeon Richter, Hungary

Structure

The basis of drug is made by 20 mkg of ethinylestradiol and 150 mkg of a dezogestrel.

As auxiliary components are Novinet's part: E 104 (dye quinolinic yellow), α-tocopherol, magnesium stearate, povidone, silicon dioxide colloid, potato starch, stearic acid, lactoses monohydrate.

Structure p / about: gipromelloza, macrogoal 6000, propylene glycol.

Release form

Tablets p / about (20 + 150) mkg. Are packaged in blisters, packaging No. 21 or No. 63.

Pharmacological action

Estrogen-progestagennoye, contraceptive.

Pharmacodynamics and pharmacokinetics

Synthetic oestrogenic and gestagenny components which show big activity, than natural sex hormones are a part of drug.

The effect is reached first of all at the expense of the prevention of allocation of hypophyseal hormones of follitropin and a lyuteotropin that interferes with process of an ovulation. Its strengthening is promoted the increased viscosity of slime in the cervical channel and, therefore, its relative impassability for spermatozoa.

Distinctive feature of tablets of Novinet is that the oestrogenic component is present at them in the minimum concentration that reduces risk of emergence of estrogenzavisimy side effects (mammary gland pains, tromboembolic episodes, nausea, addition of weight, etc.).

Dezogestrel represents gestagen the II generations. Substance favorably influences a metabolism of lipids, maintaining cholesteric balance and normalizing lipidogramma indicators.

Besides, against use of tablets:

  • blood loss is reduced;
  • the condition of skin improves;
  • the cycle of menstrual days is normalized;
  • the risk of development of gynecologic diseases decreases (including including diseases of the tumoral nature).

Ethinylestradiol also dezogestret are soaked up in proximal department of a small intestine. Absorption fast and almost 100%. A key product of a metabolism of a dezogestrel is 3-keto-dezogestrel, other its metabolites are pharmacological not active.

Bioavailability of ethinylestradiol — 60%. For a dezogestrel this indicator varies ranging from 62 to 81%. Both substances have high extent of linkng with plasma proteins (more than 90%). Their concentration in blood reaches the maximum values in 1-1,5 hours after reception of a tablet.

Components of drug are well distributed in fabrics and bodies, at the same time ethinylestradiol is characterized by ability to collect in fatty tissue. Approximately the tenth part of the accepted dose gets into milk of the feeding woman.

T1/2 — on average 24 hours, dezogestret — on average 30 hours.

Products of a metabolism of a dezogestrel are removed by kidneys. Products of a metabolism of ethinylestradiol eliminirutsya with urine and bile.

Indications to use

Protection from pregnancy.

Contraindications

Contraindications to use of tablets are:

  • hypersensitivity to the substances which are its part;
  • fibrinferments/thromboembolism of veins/arteries;
  • existence of harbingers of a thromboembolism;
  • migraines with manifestations of focal neurologic symptomatology;
  • the diabetes mellitus complicated by vascular pathologies;
  • the increased risk of thrombosis of veins/arteries;
  • pancreatitis with the expressed gipertriglitseridemiya;
  • serious pathologies of a liver (reception of tablets is contraindicated until functional indicators of body return to norm);
  • tumoral damage of a liver;
  • the hormonedependent tumors (revealed or suspected);
  • vaginal bleeding whom it is not possible to establish the origin nature;
  • otosclerosis;
  • smoking;
  • the age is more senior than 35 years;
  • pregnancy;
  • breastfeeding.

Side effects

Side effects of Novinet are shown:

  • acyclic vulval allocations;
  • amenorrhea after cancellation of tablets;
  • candidiasis;
  • change of a condition of slime in a vagina;
  • development of inflammatory processes in a vagina;
  • morbidity, tension and increase in mammary glands, allocation of milk from them;
  • nausea;
  • vomiting;
  • connected with a cholestasia jaundice and/or an itch;
  • ulcer colitis;
  • knotty or exudative erythema;
  • hloazmy;
  • enanthesis;
  • headaches;
  • changeability of mood;
  • migraine;
  • depression;
  • increase of sensitivity of a cornea of an eye to contact lenses;
  • liquid delay in an organism;
  • decrease in tolerance to carbohydrates;
  • change of body weight towards its increase;
  • hypersensitivity reactions.

At emergence of above-mentioned symptoms the issue of expediency of further administration of drug is resolved in an individual order.

Heavy side effects of Novinet which demand immediate drug withdrawal:

  • hypertension;
  • acute obstruction of veins/arteries blood clots (it is rare — a myocardial infarction, TGV, TELA, a stroke, etc.; extremely seldom — acute obstruction of large retinal and mezenterialny vessels, veins and arteries of a liver, kidneys);
  • otosclerosis and, as a result, hearing loss;
  • GUUS;
  • exacerbation of an illness of Liebman-Saks (rarely);
  • chorea of Sidenkhem (develops extremely seldom, symptoms disappear after the termination of reception of tablets);
  • porphyria.

Novinet's tablets: application instruction

Contraceptive pill of Novinet is taken by per os on one in day, washing down with liquid. Reception is begun no later than the 5th day of a menstrual cycle. Tablets are drunk without admissions and breaks within full three weeks, at the same time. From 22 to 28 day do a break.

If the first medicine is taken between 2 and 5 days of a cycle, in the first 7 days of a course apply additional measures of protection from pregnancy.

For the 29th day (the day of the week corresponds to a day of the week when the first pill was taken) reception of means is resumed, using a new pack.

In case of accurate following to the recommendations described in the application instruction of Novinet, the contraceptive effect remains also between 22 and 29 days of a cycle.

How to take a pill after childbirth/abortion

In the absence of Novinet's lactation it is allowed to accept from the first day of the first independent periods. Before reception consultation of the doctor is necessary. Additional contraception is not necessary.

In the presence of sexual contact after the delivery, administration of drug is postponed until the following periods. If the decision on reception of tablets is made later by what in 3 weeks after the delivery, in the first 7 days of a course use of additional measures of protection is shown.

After artificial abortion or spontaneous abortion reception of tablets is begun at once without use of other contraceptives.

Transition to Novinet from other contraceptives

After reception of others the COOK the first tablet is drunk next day after end of a course of the previous contraceptive (the break is not done, it is not necessary to wait for the next periods). Upon transition from the means containing only progestogen Novinet's reception is begun from the first day of a cycle.

Use of additional measures of protection in all described cases is not necessary.

Additional measures of protection are meant as use of barrier contraceptives or refusal of the sexual relations during all "dangerous" period. It is not recommended to resort to a calendar method of protection.

Periods delay

In need of a delay of the beginning of a cycle, contraceptive tablets are drunk according to the usual scheme during necessary time, without doing a break. In this case the smearing / breakthrough vulval bleedings are possible that does not influence efficiency of means. Regular reception is resumed after a standard break lasting 7 days.

Admission of a tablet

The full contraceptive effect remains on condition of regular administration of drug at which the maximum delay in reception of a tablet does not exceed 12 hours. If the forgotten medicine is taken within 36 hours after previous, Novinet continues to be accepted according to the standard scheme.

The situation when from the moment of the last administration of drug there passed more than 12 hours is considered the admission of a tablet.

If the admission of a tablet happened in the first 14 days of a cycle, next day in usual time it is necessary to drink a double dose of drug at once. Further it is accepted as usual.

If the admission happened in an interval between 15 and 21 days of a cycle, it is necessary to accept the passed dose of drug and to continue further reception without seven-day break.

In case of the admission of a tablet the risk of bloody allocations and/or ovulations increases that is connected with the minimum content of estrogen in drug. In this regard additional contraception is required (to a new cycle).

At vomiting and/or diarrhea absorption of drug cannot be full. If symptoms disappeared within 12 hours, it is recommended to take in addition the second pill (further reception — according to the usual scheme); if symptoms remain longer, during the entire period of an illness, and also all next week, additional contraception is necessary.

Overdose

Signs of overdose of drug are nausea and vomiting; bloody allocations (at reception by girls).

If overdose is noticed timely, during the first hours after reception of tablets to carry out a gastric lavage. The symptomatic treatment, an antidote is absent.

Interaction

Efficiency the COOK for per os of reception decreases in a combination with the means inducing liver enzymes: drugs Hypericum perforatum, Carbamazepine, Griseofulvin, barbiturates, Hydantoin, Rifampicin, Primidonum, Felbamat, Topiramat, Okskarbazepin.

Besides, the listed drugs increase risk of bleedings of break.

Level of induction reaches a maximum within 14-20 days, however can also remain till 4 weeks after cancellation of means.

In need of Novinet's use in combination with Tetracycline and Ampicillin during all course of treatment and a week more after its end additional contraception is necessary (the specified drugs reduce efficiency of means).

At Rifampicin reception additional measures of protection are necessary within 4 weeks after the treatment termination by drug

The COOK reduce tolerance to carbohydrates and promote increase of need for antidiabetic means for oral administration or in insulin.

With care it is necessary to apply Novinet in a combination with:

  • tricyclic antidepressants;
  • anticoagulants of an indandionovy or coumarinic row;
  • blockers of β-adrenergic receptors;
  • Bromocriptinum;
  • hepatotoxic means (in particular, with Dantrolen).

Terms of sale

According to the recipe.

Storage conditions

At a temperature from 15 to 30 °C. To protect from children.

Period of validity

3 years.

Special instructions

After a viral hepatitis it is necessary to begin reception of tablets after return to normal indicators of a functional condition of a liver (not earlier than in half a year after an illness).

The contraceptive effect decreases at:

  • to vomiting/diarrhea;
  • admission of a tablet;
  • simultaneous use with the drugs reducing efficiency the COOK.

Efficiency of tablets can decrease in cases when after several cycles of their use for the woman there are irregular, breakthrough or smearing allocations. In similar situations is considered it expedient to continue administration of drug before the termination of tablets in the following packaging.

If at the end of the 2nd cycle cancellation bleeding acyclic allocations did not stop or cancellation bleeding did not begin, administration of drug should be stopped. Renew it after only after pregnancy is excluded.

Tablets do not protect from STD and AIDS.

The oestrogenic component of drug can change separate laboratory indicators, including including indicators of a hemostasis, a functional condition of adrenal glands, kidneys, a thyroid gland, liver, level of transport proteins and level of lipoproteins.

Analogs

Novinet's analogs: Marvelon, Regulon, Mersilon, Three - Mercy.

What it is better — Jeanine or Novinet?

0,03 mg of ethinylestradiol (in Novinet's tablets this component contains in the number of 0,02 mg) and 2 mg of a diyenogest are a part of a dragee of Jeanine as actively active ingredients. The last is derivative testosterone and is characterized by anti-androgenic activity.

Thus, Jeanine contains more hormones and more suits women at whom the surplus of men's hormones is noted.

Zdravzona

  • Novinet No. 21х3 of a tablet
  • Novinet No. 21 of a tablet

Drugstore of IFC

  • Novinet tbl p / about No. 21, Gedeon Richtervengriya
  • Novinet tbl p / about No. 63, Gedeon Richtervengriya
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Apteka24

  • Novinetgedeon Richter (Hungary)
  • Novinetgedeon Richter (Hungary)

Paniapteka

  • Novinet of the tab. No. 21 Gideon Richter
  • Novinet of the tab. No. 21 Gideon Richter

BIOSPHERE

  • Novinet No. 21х3 tabl.p.o.
  • Novinet No. 21 tabl.p.o.
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Section: Contraceptives
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