Sodium nucleinate

Нуклеинат натрия Drug photo

The description is actual on 26.07.2016

  • Latin name: Sodium nucleinate
  • ATH code: L03AX
  • Active ingredient: Natrium nucleinicum (Sodium nucleate)
  • Producer: JSC Biosintez (Russia)

Structure

In 1 tablet of Natrium nucleinicum of 250 mg. Povidone low-molecular, potato starch, calcium stearate as excipients.

Release form

Tablets in a film cover of 250 mg.

Pharmacological action

Immunostimulating, a leukopoiesis stimulator.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Natrium nucleinicum is a product of a microbic origin — allocate it from hlebopekarsky yeast. From biomass of yeast allocate RNA and provide high extent of cleaning of protein impurity. Thus, it is natural drug of nucleic acids — sodium salt of low-molecular RNA.

Has a wide range of biological activity: regulates migration of T lymphocytes, strengthens phagocytosis, production of interferon, increases nonspecific resistance of an organism at immunodeficiency. Stimulates marrow (leukopoiesis) and a nucleinic exchange. Accelerates regeneration at ulcer defects, trophic ulcers, ulcer colitis. Its use reduces displays of allergic diseases.

Pharmacokinetics

Data are not provided.

Indications to use

  • complex treatment of secondary immunodeficiency (recurrent viral infections, chronic diseases of lungs, periodontosis, bacterial infections, immunodeficiency at elderly people);
  • correction agranulocytosis, lymphopenia and leukopenia;
  • disturbance of a phosphoric exchange (rickets);
  • deficit of ribonucleotides in fabrics and blood;
  • retina dystrophy;
  • for the purpose of prevention at the persons who strenuously are playing sports and being in extreme conditions.

Contraindications

  • hypersensitivity;
  • pregnancy;
  • feeding by a breast.

Side effects

Reactions of allergic type.

Sodium nucleinate, application instruction (Way and dosage)

Pill is taken inside, after meal. For adults a daily dose — 1-2 g which divide into 3-4 receptions. At different disease severity the course of treatment can fluctuate from 10 days to 6 weeks. At chronic diseases carrying out courses two — three times a year is possible.

To elderly people with immunodeficiency appoint 1 g a day 3 weeks twice in a year (usually spring and fall). At leukopenias the adult appoint on 1 tablet 2 times, a course till 10 days. To athletes during competitions in 1–1,5 g a day in 3–4 receptions. To the persons having professional harm for prevention of diseases appoint drug in a dose of 1-1,5 g a day 3 weeks 2 times a year.

Natrium nucleinicum to children about one year appoint in a dosage on 0,005 g three times a day, to children from a year to 3 flyings — on 0,015 — 0,03 g three times a day, from 3 to 5 flyings — in a dosage on 0,05 g three times a day, since 12 — appoint 0,1 g three times a day. A course till 14 days.

Overdose

Cases are not registered.

Interaction

It is not revealed.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Analogs of Nucleinate of sodium

Leucogenum, Methyluracil, Pentoxyl.

About sodium Nucleinate

At children and adults with allergic diseases signs of immune insufficiency therefore immunotropny pharmacological means are appointed come to light. In children's allergological and dermatological practice, and also to the children who are often ill 20-30 flyings ago appointed Levamisole, galavit, polyoxydoñas, Diuciphonum, gepon and sodium Nucleinate, a bit later — natural modulators: taktivin, Thymalinum, vilozen, timogen. However in the last decade more widely in clinical practice cytokines are applied. Nevertheless, long ago the known drugs find application and now. It is noted that use of Nucleinate of sodium yields positive takes at 52% of patients. In responses use of this drug for children which was appointed at frequent catarrhal diseases meets more often.

  • "… Before use of this drug the child was ill steadily once a month, later — was not ill 8 months. Drug not cheap, on a course of 1 packaging there was insufficiently".
  • "… To us the immunologist appointed to a month. One packaging did not manage. Began to be ill less often".
  • "… Appointed, but did not see effect".
  • "… I am very happy with drug since the child was ill only 3 days — so quickly he never recovered! Let's surely complete a course up to the end".

There is a positive experience of use of Nucleinate of sodium in complex treatment of a system lupus erythematosus for adults that is proved by immunological researches. In blood concentration of IgG and the CEC decreases, increases quantities of lymphocytes and activity of neutrophils to phagocytosis increases. At patients the positive effect was noted in 92% of cases.

Section: Immunity increase
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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