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As a part of one tablet Nurofen Forte — 400 mg of an ibuprofen, and also additional components: sodium citrate, sodium lauryl sulfate, sodium of a kroskarmelloz, stearic acid, sodium of a karmelloz, silicon colloid anhydride, titan dioxide, acacia, sucrose, talc, macrogoal 6000, industrial metilirovanny alcohol, water.
The nurofen is Forte made in tablets with a sugar white cover. Tablets are biconvex, round, on the one hand tablets are a red text of "Nurofen 400". Hold in blisters on 6 or 12 pieces, blisters are packed into cardboard packs.
Medicine belongs to NPVS group. Anesthetic, febrifugal medicine works as antiinflammatory.
The ibuprofen in an organism not selectively blocks TsOG-1 and TsOG-2. Its influence is caused by braking of process of synthesis of prostaglandins.
Pharmacokinetics and pharmacodynamics
In an organism after active agent gets inside, it is well soaked up from a gastrointestinal tract. The greatest concentration in blood is defined in 1-2 hours. Contacts proteins of plasma for 90%.
Slow penetration into a cavity of joints is noted, active ingredient is late in synovial fabric where higher concentration in comparison with plasma are noted. It is removed through kidneys, also with bile. Time of semi-removal is equal to 2 hours.
Indications to use
The nurofen is Forte recommended to use at such states and diseases:
- pain head and tooth;
- painful periods;
- pains rheumatic, muscular pains, dorsodynias;
- other types of pain;
- fever at patients with cold and flu.
It is not necessary to use this drug in such cases:
- high sensitivity to medicine components;
- high degree of sensitivity to other drugs from NPVS group in the anamnesis, intolerance of acetylsalicylic acid;
- erosion and ulcers of bodies of a gastrointestinal tract in the period of an aggravation;
- disturbances in the course of coagulability of blood, hemophilia;
- intracraneal hemorrhages, gastrointestinal tract bleedings;
- the recovery period after aortocoronary shunting;
- renal failure;
- liver diseases, liver failure;
- the confirmed hyperpotassemia;
- pregnancy period;
- age of the patient till 12 flyings.
Carefully elderly people, and also the patients having heart failure, an ischemic heart disease, a diabetes mellitus, hypertensia, cerebrovascular diseases, cirrhosis, a dislipidemiya, diseases of peripheral arteries, a liver, renal failure, a peptic ulcer, colitis, enteritis, a nephrotic syndrome and other heavy somatopathies need to take medicine.
It is carefully necessary to carry out treatment by that who often takes alcoholic drinks, smokes.
At reception the Nurofen some side effects Forte can be shown:
- alimentary system: vomiting, abdominal pains, a meteorism, nausea, heartburn, the ulceration mucous a gastrointestinal tract, dryness and a mucous oral cavity, pancreatitis, aphthous stomatitis is in rare instances possible;
- respiratory system: bronchospasm, asthma;
- gepatobiliarny system: hepatitis;
- sense bodys: vision disorder and hearing;
- nervous system: irritability manifestations, dizziness, drowsiness, headache, depression, disturbance of consciousness;
- cardiovascular system: tachycardia, heart failure, increase in indicators of the ABP;
- urinary system: allergic nephrite, renal failure acute, nephrotic syndrome, polyuria, cystitis;
- display of an allergy: rash, itch, Quincke's edema, bronchospasm, anaphylactoid reactions, fever, allergic rhinitis, eosinophilia, etc.;
- bodies of a hemopoiesis: anemia, agranulocytosis, leukopenia, thrombocytopenia, Werlhof's disease;
- change of laboratory indicators.
If side effects are shown, it is necessary to suspend treatment and to address the specialist. If reception the Nurofen is Forte carried out no more than 2-3 days, side effects are shown only seldom or never.
Tablets Nurofen Forte, application instruction (Way and dosage)
The provided instruction on the Nurofen Forte provides that children after 12 flyings and adults accept on 1 tablet in one step. It is necessary to wash down them with liquid.
The interval between reception of tablets has to be not less than 4 hours. It is not necessary to take more than 3 pill a day. The daily dose for teenagers till 17 flyings is equal to 1 g.
In case of overdose vomiting, nausea, a condition of block, a headache, tachycardia, bradycardia, etc. can be shown.
At overdose carrying out a gastric lavage is shown, also appoint reception of absorbent carbon. Apply an artificial diuresis, symptomatic therapy.
At a concomitant use the Nurofen Forte interacts with the following drugs:
- with acetylsalicylic acid, with any other NPVS;
- with thrombolytic drugs and anticoagulating (the probability of bleeding increases);
- with inhibitors of the return serotonin reuptake (the probability of bleedings from a gastrointestinal tract increases);
- with tsefoperazony, tsefamandoly, plikamitsiny, valproic acid, tsefotetany (the probability of a prothrombinopenia increases);
- with drugs which block canalicular secretion (concentration of an ibuprofen in plasma increases);
- with drugs of gold and cyclosporine (nephrotoxicity amplifies, the probability of hepatotoxic effects increases);
- with inductors of a microsomal oxidation (the probability of heavy intoxications increases);
- with vazodilatator (hypotensive activity goes down), with Hydrochlorthiazidum and Furosemide (the natriuretic effect decreases);
- with uricosuric drugs (lowers their efficiency), with antiagregant, indirect anticoagulants, fibrinolitikam (strengthens their action);
- with estrogen, mineralokortikoida, glucocorticoids, ethanol (side effects amplify);
- with insulin and peroral hypoglycemic drugs (strengthens their effects);
- with Colestyraminum and antacids (absorption of an ibuprofen is humiliated);
- with a methotrexate, digoxin, lithium drugs (concentration in blood of these drugs increases);
- with caffeine (analgetic action amplifies).
Terms of sale
The nurofen Forte can be bought without recipe.
It is necessary to store tablets in the dry place, temperature should not be higher than 25 degrees.
Period of validity
Forte it is possible to store a nurofen 3 years.
It is necessary to carry out treatment so that to apply a minimal effective dose during minimum short span.
If prolonged treatment practices, it is necessary to control a condition of indicators of peripheral blood, and also to trace a condition of a liver and kidneys.
It is recommended not to practice those types of activity which demand special concentration of attention during treatment.
Coincidence on the ATH code of the 4th level:
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