Ofloxacin

Офлоксацин Drug photo

The description is actual on 21.04.2016

  • Latin name: Ofloxacin
  • ATH code: J01MA01
  • Active ingredient: Ofloxacin (Ofloxacin)
  • Producer: Pharmstandard-Leksredstva, Synthesis Joint-stock Kurgan company of medical supplies and products of joint stock company, Valenta Farmatsevtika, Skopinsky pharmaceutical plant, MAKIZ-PHARMA, Obolenskoye — the pharmaceutical enterprise, CJSC Rafarm, Ozone of Ltd company, Krasfarm, Biosynthesis of joint stock company (Russia)

Structure

  • In 1 tablet — 200 and 400 mg of an ofloksatsin. Corn starch, MKTs, talc, magnesium stearate, polyvinylpirrolidone, aerosil as auxiliary components.
  • In 100 ml of solution — 200 mg of active agent. Sodium chloride and water as auxiliary components.
  • In 1 g of ointment — 0,3 g of active agent. Nipagin, vaseline, nipazol, as auxiliary components.

Release form

  • ointment in tubas on 3 g or 5 g;
  • tablets in a cover on 200 and 400 mg;
  • solution for infusions in bottles on 100 ml.

Pharmacological action

Bactericidal, antimicrobic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Ofloxacin is an antibiotic or not? It is not an antibiotic, and antibacterial agent from group of the fluorinated hinolon that not one and too. Differs from antibiotics on structure and an origin. Ftorkhinolona have no analog in the nature, and antibiotics — products of a natural origin.

Bactericidal action is connected with inhibition DNK-girazy that attracts disturbance of synthesis of DNA and cell division, change in a cell wall, cytoplasm and death of a cell. Inclusion of atom of fluorine in a molecule of quinoline changed a range of antibacterial action — it considerably extended and includes also the microorganisms steady against antibiotics and strains developing beta lactamelements.

Gram-positive and gram-negative microorganisms, and also chlamydias, ureaplasmas, mycoplasmas, gardnerella are sensitive to drug. Suppresses growth of mycobacteria of tuberculosis. Does not affect Treponema pallidum. Resistance of microflora develops slowly. The expressed post-antibiotic effect is characteristic.

Pharmacokinetics

Absorption after intake good. Bioavailability of 96%. The insignificant part of drug contacts proteins. The maximum concentration is defined by 1 h. It is well distributed in fabrics, bodies and liquids, gets in cells. Considerable concentration are observed in saliva, a phlegm, a lung, a myocardium, a mucous membrane of intestines, bones, prostate gland tissue, female generative organs to skin and cellulose.

Well gets through all barriers and into medullispinal liquid. About 5% of a dose Biotransformirutsya in a liver. The elimination half-life is equal to 6-7 h. At repeated introduction cumulation is not expressed. Also the insignificant part with bile is removed by kidneys (80-90% of a dose). At a renal failure of T1/2 increases. At a liver failure removal can be slowed down too.

Indications to use

Contraindications

  • age till 18 flyings;
  • hypersensitivity;
  • pregnancy;
  • breastfeeding;
  • epilepsy or the increased convulsive readiness after craniocereberal injuries, disturbances of cerebral circulation and other diseases of TsNS;
  • earlier noted damage of sinews after reception of ftorkhinolon;
  • peripheral neuropathy;
  • lactose intolerance;
  • age till 1 year (for ointment).

With care it is appointed at organic diseases of a brain, gravis myasthenia, heavy abnormal liver functions and kidneys, a hepatic porphyria, heart failure, a diabetes mellitus, a myocardial infarction, Bouveret's ventricular disease, bradycardia, at advanced age.

Side effects

The met side reactions are more often:

Less often and very seldom met side reactions:

  • increase of activity of transaminases, cholestatic jaundice;
  • hepatitis, hemorrhagic colitis, pseudomembranous colitis;
  • headache, dizziness;
  • concern, irritability;
  • sleeplessness, intensive dreams;
  • uneasiness, phobias;
  • depression;
  • tremor, spasms;
  • paresthesias of extremities, peripheral neuropathy;
  • conjunctivitis;
  • sonitus, hearing disorder;
  • disturbance of color sensation, doubling in eyes;
  • taste disturbances;
  • tendinitis, mialgiya, arthralgias, extremity pain;
  • rupture of sinews;
  • heart consciousness, ventricular arrhythmia, hypertensia;
  • dry cough, asthma, bronchospasm;
  • petechias;
  • leukopenia, anemia, thrombocytopenia;
  • renal failures, dysuria, ischuria;
  • rash, skin itch, small tortoiseshell;
  • intestinal dysbiosis.

Application instruction of Ofloksatsin (Way and dosage)

Ointment Ofloxacin, application instruction

For a lower eyelid 1 - 1,5 cm of ointment 3 times a day is put. In the presence of Chlamidia damages of eyes — 5 times a day. Treatment is carried out no more than 2 weeks. At simultaneous use of several drugs ointment is used by the last.

Tablets Ofloxacin, application instruction

Pill is taken inside, entirely, to or during food. The dose is selected depending on weight of an infection, function of a liver and kidneys. A usual dose — 200-600 mg a day, divided into 2 receptions. At heavy infections and at the excess weight of the patient the daily dose increases to 800 mg. At gonorrhea 400 mg in one step, once, in the first half of day are appointed.

To children it is appointed according to vital indications if there is no replacement with other means. The daily dose makes 7,5 mg on weight kg.

The patient with a renal failure carries out correction of the mode of dosing. Patients with the expressed abnormal liver functions a daily dose have to have no more than 400 mg. Duration of treatment is defined by disease severity. Treatment is continued by 3 more days after normalization of temperature or after the laboratory analyses confirming a microorganism eradikation. Most often duration of a course of treatment is 7-10 days, at salmonelloses of 7 days, at infections of urinary tract till 5 days. Treatment should not be more than 2 months. At treatment of some diseases at first Ofloxacin in / twice a day with transition to oral administration is appointed.

Drops with active agent ofloxacin are issued under the name Dantsil, Floksal, Unifloks. You watch the application instruction of these drugs.

Overdose

It is shown by dizziness, block, drowsiness, confusion of consciousness, a disorientation, spasms, vomiting. Treatment consists in a gastric lavage, carrying out an artificial diuresis and symptomatic therapy. At a convulsive syndrome use Diazepam.

Interaction

At the purpose of a sukralfat, antiacid means and drugs containing aluminum, zinc, magnesium or iron absorption of an ofloksatsin decreases. Increase in efficiency of anticoagulants of indirect action at reception with this drug is noted. Control of coagulant system is necessary.

The risk of neurotoxic effects and convulsive activity increases at co-administration of NPVP, derivatives of a nitroimidazole and methylxanthines.

At use with Theophylline its clearance decreases and the elimination half-life increases.

Simultaneous use of hypoglycemic means can entail hypo - or hyper glycemic states.

At use with Cyclosporine increase in its concentration in blood and an elimination half-life is observed.

Probenetsid, Furosemide, Cimetidinum and the Methotrexate reduce canalicular secretion of active agent that attracts increase of its concentration in a blood plasma.

Perhaps sharp lowering of arterial pressure at use of barbiturates and hypotensive drugs.

At use with glucocorticosteroids there is a risk of a rupture of sinews.

Lengthening of an interval of QT at use of neuroleptics, antiarrhytmic drugs, tricyclic antidepressants, macroleads, derivative imidazole, an astemizola, a terfenadina, an ebastina is possible.

Use of inhibitors of a karboangidraza, Natrii hydrocarbonas and citrates which alkalize urine increases risk of emergence of a crystalluria and nephrotoxic action.

Terms of sale

It is released according to the recipe of the doctor.

Storage conditions

Temperature of storage is up to 25 °C.

Period of validity

3 years.

Ofloxacin and alcohol

Alcohol is not compatible to this drug. During treatment reception of alcoholic beverages is forbidden.

Ofloksatsin's analogs

The tableted drugs: Zanotsin, Zofloks, Ofloksin.

Solutions for infusions: Oflo, Tarivid, Ofloksabol.

Ofloksatsin's analog which is let out in the form of an oculentum — Floksal, in the form of drops eye/ear — Dantsil, Unifloks.

Zdravzona

  • Ofloxacin 2mgml solution for infusions of 100 ml No. 48 of a flakonykrasfarm of joint stock company
  • Levofloxacin 5mgml 100 of ml No. 12 fl.
  • Ofloxacin hl ointment. 0,3% 5 g
  • Levofloxacin 5mgml solution for infusions of 100 ml No. 1 of a flakonkrasfarm of joint stock company
  • Levofloxacin STADA 500 of mg No. 5 of a tablet

Drugstore of IFC

  • Tsiprofloksatsin-Tev tbl p / about 500 mg No. 10, Pharmaceutical plant of Tev Prayvet of Kovengriya
  • Ofloksatsin-Tev tbl p / about captivity. 200 mg No. 10, Tevavengriya
  • Drop ciprofloxacin eye 0,3% 10 ml - tubes droppers, Updating of CJSC Pfkrossiya
  • Levofloxacin tbl p/pl/o 500 mg No. 5, Zaorossiya's Vertexum
  • Levofloxacin tbl p/pl/o 500 mg No. 10, Zaorossiya's Vertexum
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Apteka24

  • Levofloxacin
  • Tablet levofloxacin coated 500 mg No. 10 Health (Ukraine, Kharkiv)
  • Tablet levofloxacin coated 250 mg No. 10 Health (Ukraine, Kharkiv)
  • Ofloksatsinkiyevmedpreparat (Ukraine, Kiev)
  • Ofloksatsindarnitsa (Ukraine, Kiev)

Paniapteka

  • Ofloxacin solution inf. 0.2% 100mllekhim-Kharkiv
  • Ofloxacin solution inf. 0.2% 100mllekhim-Kharkiv
  • Ofloxacin solution inf. 0.2% 100mllekhim-Kharkiv
  • Ofloxacin solution inf. 0.2% 100mllekhim-Kharkiv
  • Ciprofloxacin solution of infusional 0.2% 100mlnovofarm-Biosintez

BIOSPHERE

  • Ciprofloxacin of 0,25 g No. 10 tabl.p.o. Synthesis of joint stock company (Russia)
  • Ofloxacin of 0,3% 5 g ointment glazn. Synthesis of joint stock company (Russia)
  • Ciprofloxacin of 0,5 g No. 10 tabl.p.o. Synthesis of joint stock company (Russia)
  • Ciprofloxacin of 200 mg 100 ml solution for infection. Kelun pharmaceutical plant (China)
  • Ofloxacin of 2 mg/ml 100 ml solution for inf. Synthesis of joint stock company (Russia)
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Section: Antimicrobic
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ofloxacin surely consult with the attending physician.