Окситетрациклин Drug photo

The description is actual on 31.05.2016

  • Latin name: Oxytetracycline
  • ATH code: D06AA03
  • Active ingredient: Oxytetracyclinum (Oxytetracycline)
  • Producer: Jiangxi Guoyao Pharmaceutical Limited-Liability Company, Sichuan Long March of Pharmaceutical To., Ltd. (China)


To be rolled into one 0,1 g (100 000 PIECES) of hydrochloride Oxytetracyclinum.

One tablet, coated, can contain 0,1 or 0,25 g of Oxytetracyclinum of a hydrochloride.

Release form

Substance-powder, solution for injections or a tablet in covers.

Pharmacological action

Antibacterial and antimicrobic action.

Pharmacodynamics and pharmacokinetics

Oxytetracyclinum the hydrochloride is an antibiotic from group of tetracyclines which has a big action spectrum and shows activity on the relation, as to gram +, and gram - to bacteria, rickettsiae, spirochetes, chlamydias and mycoplasmas.

The mechanism of action is based on preventing of reproduction of bacteria, that is bacteriostatically: getting in a cell active agent, contacts receptors 30S — subunits in a bacterial ribosome, blocks communication aminoacyl - the transitem RNA that does not allow to join to new amino acids in the following peptide chains under construction and as a result – protein synthesis processes are completely broken. Action is selective as microorganisms have low ability to concentrate tetracyclines in cells of mammals.

Indications to use

Drug is effective at various bacterial infections: at pneumonia, bronchitis, a pleura empyema, quinsy, cholecystitis, an endometritis, prostatitis, and also at purulent complications after surgical interventions.

Oxytetracyclinum in veterinary science is used in the form of drug — Oxytetracyclinum-100. To them various diseases of a gastrointestinal tract, respiratory and urinogenital system, skin at cattle treat, goats, calfs, sheep, pigs, cats and dogs. Causative agents of diseases have to be sensitive to Oxytetracyclinum, for example: the microorganisms causing pneumonia, bronchitis, bronchial pneumonia, enteritis, salmonellosis, dysentery, an endometritis and so forth.


Use of Oxytetracyclinum is dangerous if:

  • the person has the known hypersensitivity to tetracyclines;
  • the woman is on II or the III trimester of pregnancy;
  • the child did not reach 8 years;
  • the patient has a heavy renal and/or liver failure, a system lupus erythematosus, mycosis.

Side effects

  • anorexia, nausea, vomiting, abdominal pains, glossitis, stomatitis, proctitis, diarrhea;
  • prolonged use leads to increase of activity of enzymes of a liver — transaminases and alkaline phosphatases, to increase of content of urea, candidiasis, deficit of vitamin K and group B, and also to a hyperbilirubinemia, a prothrombinopenia;
  • coloring of teeth in yellowy-brown color, an enamel hypoplasia;
  • skin rash, itch, photosensitization, eosinophilia, even the Quincke's edema is possible;
  • hemolitic anemia, thrombocytopenia;
  • the increased intracranial pressure which can cause vomiting, a headache, a diplopia, a papilledema.

Oxytetracyclinum, application instruction (Way and dosage)

It is possible to use drug inside and outwardly, in oil and locally.

Before appointing drug at first define sensitivity of microflora and the activator to drug, weight of course of infectious process.

Dosage depending on weight of course of a disease

If infectious process of an easy current, then 7,5-1 g for 3-4 receptions whereas the medium-weight current demands high doses — 1,5-2 g for 3-4 receptions appoint.

At a renal failure and/or functional disturbances of a liver

Appoint smaller doses or a bigger interval, individually changing the scheme of treatment.


Manifestation in the form of lactoacidosis and an intestinal dysbiosis is possible. At the same time cancel therapy and carry out a symptomatic treatment.


In a combination with the following drugs reactions of medicinal interaction or change of pharmacokinetics are possible:

  • About magnesium - aluminum - calcium - ferriferous drugs antacids, worsens absorbability.
  • With anticoagulants the probability of a prothrombinopenia increases.
  • With bactericidal antibiotics (penicillin and cephalosporins), decrease in their efficiency is observed.
  • With Streptomycin, Gentamycin activity in relation to intracellular activators increases (for example, to brucellas, pasterella).
  • With Chymotrypsin concentration and time of circulation of Oxytetracyclinum increases.
  • To estrogensoderzhashchy oral contraceptives there is a decrease in their efficiency and increase in risk of breakthrough bleedings.
  • With Retinolum intracranial pressure increases.

Terms of sale

Drug is released according to the recipe.

Storage conditions

The dry, protected from rays of light place where temperature does not increase more than +25 °tselsiya.
You store in the unavailable place for juvenile children.

Period of validity

No more than 36 months.

Special instructions

For the purpose of prevention of a hypovitaminosis it is necessary to accept vitamin K and groups B, beer yeast.

There is a risk of development of a photosensitization that demands insolation restriction.

Prolonged treatment assumes periodic control of a functional condition of a liver, kidneys and bodies of a hemopoiesis.

As drug can mask symptoms of syphilis and possible multi-infection, carry out monthly serologic assay within 4 months.


Coincidence on the ATH code of the 4th level:

Drug or substitutes usually are absent in drugstores, however, there are group analogs:

Section: Antibiotics
in more detail

Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Oxytetracyclinum surely consult with the attending physician.