Omeprazol

Омепразол Drug photo

The description is actual on 29.07.2015

  • Latin name: Omeprazole
  • ATH code: A02BC01
  • Active ingredient: Omeprazol (Omeprazole)
  • Producer: PAO Farmak, PAO Kiyevmedpreparat (Ukraine), LLC OZON (Russia), TEVA Pharmaceutical Industries, Ltd. (Israel), Gedeon Richter Plc. (Hungary)

Structure

20 mg of pellets in terms of omeprazol are a part of one capsule. Peleta represent microgranules of spherical shape. Auxiliary components of pellets: additives of E421, E217, E171, E219, E170; dodetsilsulfat and hydrosodium phosphate, dodecahydrate, cetyl alcohol, sucrose, gipromeloza.

40 mg of an omeprazol, and also sodium hydroxide and dinatrium edetat are a part of lyophilisate.

Release form

Capsules to / r 0,02 g (packaging No. 10, No. 30, No. 60, No. 100 and No. 120).

Lyophilisate for preparation of solution for in/in introductions and infusional therapy (bottles on 40 mg).

Pharmacological action

Antiulcerous, inhibiting a proton pomp.

Pharmacological group: proton inhibitor.

Pharmacodynamics and pharmacokinetics

Omeprazol inhibits a proton pomp (N + / To +-Atfazu) in covering (obkladochny) cells of a stomach, blocking thereby a closing stage of formation of chlorohydrogen (hydrochloric) acid.

Drug begins to work within the first 60 minutes after reception. The effect remains within the next 24 hours, at the same time it reaches peak 2 hours later after reception.

At an ulcer of a 12-tiperstny gut reception of 0,02 g of drug allows to support within 17 hours an indicator of intragastric acidity at the level of 3. For a complete recovery of secretory activity 3-5 days there are enough.

Substance is quickly absorbed from the digestive channel. Tsmakh varies ranging from 30 till 60 minutes, bioavailability — from 30 to 40%. Drug approximately for 90% contacts plasma proteins and is almost in full metabolized in a liver.

T1/2 — of 30 minutes till 1 o'clock. Products of a metabolism are removed mainly by kidneys. At HPN excretion decreases in proportion to decrease in Clcr. At elderly people removal decreases at simultaneous increase in bioavailability. At a hepatic unsufficiency of T1/2 makes 3 hours at absolute bioavailability.

Indications to Omeprazol's use

From what Omeprazol in capsules?

Indications to Omeprazol's use by Acre differ in nothing from indications which are listed in the summary of Omeprazol made by other pharmaceutical enterprise (Sandoz, Gedeon Richter Plc., STADA CIS, etc.). Medicine is effective at:

  • benign stomach ulcer / 12-tiperstnoy-tiperstnoy number if the disease is connected with reception of NPVP);
  • eradikatsionny therapy of N. of pylori (in a combination with antibacterial HP);
  • GERB;
  • prevention of aspiration of acid gastric contents;
  • ulcerogenic adenoma of PZhZh;
  • weakening of symptoms of kislotozavisimy dispepsichesky frustration (drug helps at heartburn, eliminates weight in a stomach, an eructation, a meteorism, swelling, unpleasant smack and nausea).

From what Omeprazol helps (Acre, Stada, Sandoz, Richter and so forth) at the specified diseases? Drug, operating on molecular level, suppresses synthesis of hydrochloric acid obkladochny cells mucous a stomach and prevents strengthening of secretion after meal.

Thus, at treatment by Omeprazol fast regress of the stomach diseases caused by disturbance of acidity and/or a 12-tiperstny gut is noted, symptoms of dyspepsia and pain leave, overall health improves.

Provoking permanent decrease in acidity, drug creates optimal conditions for a successful eradikation of N. of pylory which is the reason of 90% of all gastritises and a peptic ulcer.

Omeprazol at gastritis

At gastritis Omeprazol appoint only when at the patient acidity of a gastric secret is increased.

At hypo - and normoatsidny gastritises use of drug is contraindicated as can provoke thinning of a mucous membrane, reduction of amount of glands and secretory insufficiency of a stomach at zero acidity of the digestive juice which is contained in it.

Optimum dose at gastritis — 20 mg/days. Treatment, as a rule, lasts from 2 to 3 weeks. If the disease is associated with H. pylori infection, sick along with Omeprazol appoint antibacterial drugs on one of the schemes, standard for such cases.

Omeprazol's use from heartburn

The Inhibitors of a Proton Pomp (IPP) in small doses (for example, capsules Omeprazol Sandoz which contain 10 mg of active agent) belong to group of drugs of non-prescription dispensing and can be used for treatment of periodically arising heartburn.

Consultation of the doctor is necessary if:

  • the patient has other symptoms (decrease in body weight, pain in epigastriums or behind a breast, a dysphagy);
  • recurrence of heartburn becomes frequent.

The oldest and most known way of stopping of heartburn is use of Al/MgCa of the containing antiacid means of which mechanism of action ability to neutralize hydrochloric acid in a stomach gleam is the cornerstone.

Their only advantage is speed. Shortcomings are the brevity of effect (no more than 1,5 hours), ability to provoke the disturbances of a chair (depending on structure of HP at the patient can be noted a lock or diarrhea) connected with absorption of the ions which are contained in their structure side effects.

Besides, antiacid drugs rather aggressively enter interaction with other HP, breaking at the same time absorption of at the same time taken medicine. At the heartburn which is manifestation of GERB efficiency of antacids it is very low.

Other group of means which were traditionally used for treatment of heartburnalginates. They do not possess neutralized action, and create a mechanical barrier which does not allow contents of a stomach to get into a gullet.

Despite all advantages of alginates and antacids, at heartburn means which suppress formation of hydrochloric acid are considered as the most efficient. Before implementation of IPP, blockers H2-gistaminoretseptorov were the most popular means.

Their effect comes later, than the effect of alginates or antacids (it is caused need of receipt of these HP in a system blood stream), but at the same time remains within 8-12 hours.

Lack of blockers H2-gistaminoretseptorov is that for stopping of the persistent, repeating heartburn their use in doses for nonprescription use not always gives the necessary effect.

Also at reception H2-gistaminoblokatorov in small doses the phenomenon which is known as "an effect uskolzaniye" that it can be connected with development of tolerance to data of HP can form.

Besides, they — in particular drugs of the first generations — have the expressed oppressing effect on system of a microsomal oxidation of a liver and can enter interactions with at the same time accepted by HP (changing at the same time their pharmacokinetic parameters).

H2-gistaminoblokatory potentsiirut effect of alcohol that does them inefficient for stopping of the heartburn caused by the use of alcohol.

The most effective at the moment by method of treatment of heartburn (including heartburn which arises at night) use of nonprescription IPP which contain 10 mg of an omeprazol is considered.

The full therapeutic effect of drug at heartburn is reached in the first 4 days though certain patients have a disappearance of symptoms and full simplification it is noted in the first days of use of Omeprazol.

Use of small doses of drug "on demand" for treatment not erosive a reflux esophagitis more than at a half of patients promotes elimination of dispepsichesky symptoms at least for half a year.

Omeprazol is well had by patients and has low risk of development of serious by-effects in the patients accepting it. At reception of low doses of drug the undesirable phenomena, as a rule, single are also characterized by moderate degree of manifestation.

Side effects which are described in the reference book Vidal and Wikipedias at prolonged use of high doses of IPP at reception of small doses of an omeprazol do not arise.

For what Omeprazol appoint at pancreatitis?

At chronic pancreatitis Omeprazol's efficiency is caused by his ability to reduce intra pancreatic pressure due to secretion suppression and by that to reduce load of the inflamed and weakened pancreas (PZhZh).

Thus, the purpose of purpose of drug at pancreatitis is ensuring the maximum rest of PZhZh.

In addition, chronic pancreatitis in most cases is complicated by GERB which basic reasons are disturbance of motility of a gullet and stomach, weakness of sphincters of a gullet, and also hiatalny hernia in combination with the strengthened secretion of acid in a stomach.

Getting into a gullet, acid contents of a stomach provoke heartburn, pain behind a breast, acid smack, reflex cough and increase of cases of development of caries of teeth.

Omeprazol helps from heartburn and eliminates other dispepsichesky symptoms, significantly facilitating a current of GERB, reducing intensity of its manifestations and unloading PZhZh. Drug can be used also more is long (of one month before half a year).

For what appoint in/in Omeprazol's introduction?

In \in use of drug it is shown as an alternative to reception of capsules in the following cases:

  • treatment and prevention of recurrence of an ulcer of a 12-tiperstny gut;
  • treatment and prevention of recurrence of stomach ulcer;
  • H. pylori eradikation at a peptic ulcer (in a combination with the appropriate antibacterial agents);
  • treatment and prevention of the peptic ulcer connected using NPVP (including patients have risk groups);
  • therapy a reflux esophagitis (including prolonged treatment of patients with an inactive form of a disease);
  • treatment of symptomatic GERB;
  • treatment of ulcerogenic adenoma of PZhZh.

Contraindications

Contraindications to use of drug are age till 5 flyings (at the body weight of the child to 20 kg), a lactation and hypersensitivity to an omeprazol or contained in capsules/lyophilisate to excipients.

Side effects

Side effects of drug are shown in a look:

  • dysfunctions of system of digestion (an abdominal pain, frustration of a chair, nausea, vomiting, a superactivity of enzymes of a liver, a meteorism, taste disturbance, stomatitis, dryness mucous in a mouth, liver dysfunction, at patients with the previous heavy pathology of a liver can develop hepatitis).
  • Dysfunctions of the hemopoietic bodies which symptoms are leucio-, pantsito-, thrombocytopenia, an agranulocytosis.
  • Dysfunctions of skeletal and muscular system (mialgiya, arthralgia, myasthenia).
  • Disturbances from an integument (a photosensitization, an enanthesis, a skin itch, an alopecia, a multiformny exudative erythema).
  • Dysfunctions of NANOSECOND: at patients with the accompanying heavy somatic pathologies dizzinesses, headaches, a depression or excitement are possible; patients with the previous serious illness of a liver have an encephalopathy.
  • Hypersensitivity reactions: bronchospasm, fever, Quincke's disease, small tortoiseshell, acute anaphylaxis, intersticial nephrite.
  • Other disturbances: gynecomastias, a febricula, peripheral hypostases, vision disorders, a hyperhidrosis, formation of benign glandulyarny (ferruterous) cysts in a stomach (pathology develops at prolonged use of drug as result of suppression of secretion of HCl and is reversible).

Powder and Omeprazol's tablets: application instruction

The application instruction of Omeprazol-Acre (a capsule to / r)

The daily dose of medicine depends on indications:

  • peptic ulcer, ezofagealny reflux — 20 mg;
  • reflux esophagitis — 20, at heavy disease — 40 mg;
  • recurrence prevention a reflux esophagitis and a peptic ulcer — 10 mg (in small doses drug is allowed to be accepted it is long);
  • prevention of an acid and aspiration pneumonitis — 40 mg once for an hour to surgical intervention (if operation lasts more than 2 hours, repeated introduction of a necessary dose is shown to the patient);
  • kislotozavisimy dyspepsia — 10-20 mg;
  • ulcerogenic adenoma of PZhZh — 20-120 mg (if the dose exceeds 80 mg/days, it it is necessary to divide into 2-3 receptions).

Omeprazol's reception in a dose of 40 mg/days is shown to patients, resistant to other antiulcerous drugs.

For N.'s eradikation of pylori use one of the approved international schemes of treatment, according to each of which Omeprazol it is necessary to accept 2 rubles/days on 20 mg in addition to the main therapy.

At an ulcer of a 12-tiperstny gut therapy can be "double" or "triple".

"Triple" therapy is carried out as follows:

  • the first week — Amoxicillin + Klaritromitsin (twice a day on 1 and 0,5 g, respectively);
  • the second week — Klaritromitsin + Metronidazole (twice a day on 0,25 and 0,4 g, respectively; instead of Metronidazole it is possible to accept 0,5 mg of Tinidazolum);
  • the third week — Amoxicillin + Metronidazole (three times a day on 0,5 and 0,4 g, respectively).

"Double" therapy: 0,75 g of Amoxicillin of 2 rubles/days within 14 days + 0,5 g of Klaritromitsin of 3 rubles/days within 14 days.

"Double" therapy at stomach ulcer: 0,75-1 g of Amoxicillin of 2 rubles/days within 14 days.

Klaritromitsin, Trichopolum, Omeprazol and De-Nol can be also applied to N.'s eradikation of pylori. Klaritromitsin and Trichopolum appoint 15 mg/kg/days in a dose, Omeprazol — in a dose of 0,02 g of 1 ruble/days, De-Nol should accept 4 rubles/days on 1 tablet. Duration of such therapy — 10 days.

To children of a capsule of Omeprazol appoint since 5 years (weighing not less than 20 kg).

The application instruction Omeprazol-Richter and other generics of drug is similar to the instruction to Omeprazol-Acre.

How to accept Omeprazol — to food or later?

Capsules accept inside with a small amount of liquid (it is possible with food), without crushing, without chewing, without damaging integrity of a cover. Preferable time of reception — morning hours (before meal).

How it is long possible to accept Omeprazol?

Course duration at an ulcer of a 12-tiperstny gut depending on features of a clinical picture and the response of an organism of the patient to treatment makes from 2 to 5 weeks, at a reflux esophagitis and stomach ulcer — from 4 to 8 weeks.

At kislotozavisimy dyspepsia the course lasts 2-4 weeks. If after its end symptoms do not disappear or quickly appear again, it is necessary to revise the diagnosis of the patient. If necessary drug continues to be accepted in a smaller single dose.

In the presence of indications Omeprazol can be applied long enough (erosion and ulcer defects mucous a stomach / 12-типерстной guts will not heal yet). At ulcerogenic adenoma of PZhZh the course of treatment can stretch till 5 flyings.

Omeprazol: how to accept drug for self-treatment?

(With a dosage of active agent of 10 mg) without approval of the attending physician 14 days are longer not recommended to accept OTC medicines of an omeprazol.

Features of use of Omeprazol in/in

Intravenous administration of drug is alternative of peroral therapy in cases when reception of capsules is impossible.

Standard dose — 40 mg of 1 ruble/days intravenously. Treatment of patients with ulcerogenic adenoma of PZhZh begin 60 mg/days with a dose. If there is a need of use of higher doses, the scheme of treatment is selected individually. If the daily dose exceeds 60 mg, it needs to be divided into 2 introductions.

Intravenously the drug is administered in the form of infusion lasting from 20 minutes before half an hour.

Before introduction contents of a bottle are dissolved of 5 ml, and then at once bring volume to 100 ml. As solvent use solution of glucose of 5% or NaCl solution of 0,9%. Stability of drug depends from rn solvent therefore for cultivation it is not necessary to use:

  • other solutions;
  • bigger amount of solvent.

Infusion solution has to be used at once after preparation. Any remains or waste have to be utilized.

Overdose

Symptoms of overdose of Omeprazol: confusion of consciousness, drowsiness, decrease in clearness at perception of visual objects, a headache, dryness of a mucous oral cavity, nausea, arrhythmia, tachycardia.

Therapy: symptomatic. The hemodialysis is considered insufficiently effective.

Interaction

Prolonged use of drug in a dose of 0,02 g of 1 ruble/days in a combination with Theophylline, Naproxenum, caffeine, Piroxicam, Metoprolol, Diclofenac, ethanol, Propranolol, Cyclosporine, Quinidine, Lidocaine and Oestradiol does not lead to change of their plasma concentration.

At simultaneous use with antacids interaction was not noted.

Omeprazol influences bioavailability of any of HP which absorption depends on value of an indicator of acidity (iron salts, for example).

Terms of sale

According to the recipe.

The recipe on Latin (sample):

Rp.: Omeprazoli 0,02
D.t.d.N.10 in caps.
S. 1-1

Storage conditions

Temperature of storage should not exceed 25 °C. To protect from children.

Period of validity

For lyophilisate — 2 years. For capsules — 3 years.

Special instructions

Due to the probability of emergence of side effects from NANOSECOND Omeprazol drivers of vehicles and persons who work with potentially dangerous mechanisms should apply with care.

Omeprazol's analogs

Synonyms (Omeprazol's analogs with the same active ingredient): Omeprazol-Acre, Omeprazol-Teva, Gastrozol, Omeprazol-Stada, Zerotsid, Omez, Omipiks, Omitoks, Omizak, Omeprazol-Richter, Promez, Ultop, Helitsid.

Similar drugs with the similar mechanism of action: Gelikol, Krosatsid, Lansofed, Lantsid, Pariyet, Parkour, Ontaym, Nolpaza, Neksium, Ultera, Epicurus, Neo-zekst, Razo, Peptazol, Pantoprazol, RabeprazolDe-Nol, Esomeprazole.

Omez or Omeprazol — what is better? In what Omeprazol and Omez's difference?

Enters into Omez and Omeprazol's structure the same active agent, that is the only thing, than one drug differs from another — structure of auxiliary components and the price (Omez is approximately twice dearer than Omeprazol).

Responses demonstrate that both means are equally effective at kislotozavisimy diseases and are equally well transferred by an organism: both Omeprazol, and its analog quickly get in mucous a gastrointestinal tract and then are absorbed in blood, within an hour reach the maximum concentration and quickly eliminate pain and discomfort in a stomach.

Esomeprazole and Omeprazol — a difference?

Esomeprazole represents left-handed isomer of an omeprazol and has structure, other than other IPP.

Both drugs have the similar mechanism of action, but pharmacokinetic parameters of esomeprazole are to a lesser extent subject to individual fluctuations, than pharmacokinetic parameters of its analog.

In this regard Esomeprazole is characterized by higher clinical predictability and reliability of pharmacotherapy. Its anti-secretory effect is shown quicker and is more expressed and stabler in comparison with that for Omeprazol.

Omeprazol and Pantoprazol — what is better?

Omeprazol represents highly effective and rather safe drug for treatment of the diseases associated with the increased intensity of development of a gastric secret.

Its analog Pantoprazol is characterized by higher bioavailability, but at the same time smaller anti-secretory activity and a therapeutic effectiveness at treatment a reflux esophagitis and a round ulcer.

Choosing from two IPP, Pantoprazol is unambiguously given preference only in need of use in a combination with Tsitalopram and Klopidogrel.

Rabeprazol and Omeprazol — differences?

Rabeprazol differs from Omeprazol the fact that he:

  • works with broader range of acidity (from 0,8 to 4,9);
  • gives smaller quantity of side effects (2% at 15% for Omeprazol) and the best portability;
  • suppresses gastric secretion more reliably that allows to predict better clinical performance at different patients;
  • to a lesser extent, than other IPP, influences a metabolism of drugs at simultaneous use with them.

Meal does not change Rabeprazol's bioavailability, the withdrawal is absent. The last is connected with the fact that on recovery of secretory activity 5-7 days leave.

Thus, Omeprazol is basic drug with side effects, Ezometrazol represents the improved drug on the basis of left-handed isomer of an omeprazol, Rabeprazol is considered the safest among other IPP.

What it is better — Nolpaza or Omeprazol?

Nolpaza is IPP which basis is rabeprazol. Thus, at efficiency, identical with Omeprazol, he can be considered as safer from the point of view of emergence of side effects.

Zdravzona

  • Omeprazol sandoz 40 mg No. 14 kapsulylek D.D.
  • Omeprazol of 20 mg No. 20 capsule/ozone/ozone of Ltd company
  • Omeprazol of 20 mg No. 10 capsule/ozone/ozone of Ltd company
  • Omeprazol of 20 mg No. 14 kaps.lek D.D.
  • Omeprazol of 20 mg No. 30 kapsulysintez joint stock company

Drugstore of IFC

  • Omeprazol-Richter kaps 20 mg No. 14, Liconsa/Gideon - Richter-RUS Zaorossiya
  • Omeprazol Teva kaps 10 mg No. 28, Tevaizrail
  • Omeprazol-Richter kaps 20 mg No. 28, Liconsa/Gideon - Richter-RUS Zaorossiya
  • Omeprazol Teva kaps 40 mg No. 28, Tevaizrail
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Apteka24

  • Omeprazol of a capsule 0.02g No. 10astrafarm (Ukraine, Cherry)
  • Omeprazol of a capsule 0.02g No. 10farmak (Ukraine, Kiev)
  • Omeprazol of a capsule 0.02g No. 30farmak (Ukraine, Kiev)
  • Omeprazol liofil.dlya solution fl. 40 mg No. 1farmeks of Groups of Ltd company (Ukraine, Borispol)
  • Omeprazolanfarm Hellas (Greece)

BIOSPHERE

  • Omeprazol of 20 mg No. 30 kaps.rastvor./kishechn. Synthesis of joint stock company (Russia)
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Section: Gastrointestinal
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Omeprazol surely consult with the attending physician.