Orgil

Оргил Drug photo

The description is actual on 30.06.2016

  • Latin name: Orgyl
  • ATH code: P01AB03
  • Active ingredient: Ornidazol (Ornidazole)
  • Producer: Kusum Heltkhker Pvt. Ltd. (India)

Structure

Ornidazol, microcrystallic cellulose, starch, magnesium stearate, sodium of a kroskarmeloz, Opadry covering orange, water.

Release form

Tablets of 500 mg in a cover of orange color, a round form, in the blister, in a cardboard pack No. 10.

Pharmacological action

Antiprotozoan, bactericidal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Drug belongs to derivatives 5 nitroimidazoles which active ingredient is DNK-tropnymi properties, possessing antiprotozoan and bactericidal action. Ornidazol is active concerning protozoa (lyambliya, trichomonads, gardnerell, a dysenteric amoeba, leyshmaniye, balantidiya), and also gram-negative and gram-positive bacteria.

Pharmacokinetics

Ornidazol after oral administration is quickly and well soaked up from a gastrointestinal tract (about 90%). The maximum concentration in blood can be found in 3 hours. With proteins of plasma communication weak (about 13%). Well gets into all fabrics and liquids of an organism.

The cumulation coefficient at course administration of drug of an ornidazol in a dose of 500 mg or in the 12th hour makes 2,5. The metabolism happens in a liver to education alpha hydroxymethyl and hydroxymethyl of metabolites which have rather low pharmacological activity of rather anaerobic activators and Trіchomonas vagіnalіs, than not changed Ornidazol. It is removed with urine, mainly in the form of metabolites. An elimination half-life — 13 hours.

Indications to use

  • Treatment of trichomoniasis, amebiasis (intestinal infections and abenteric forms of an amebiasis), lambliasis;
  • Prevention of mephitic gangrenes at operative measures in gynecologic practice.

Contraindications

High sensitivity to drug, TsNS diseases (multiple sclerosis, epilepsy), age till 3 flyings, pregnancy and the period of a lactation.

Side effects

  • nausea, gastrointestinal frustration;
  • drowsiness, headache, dizziness, incoordination, tremor, spasms, fatigue, loss of consciousness, neuropathy, hypersensitivity reactions.

Orgil, application instruction (Way and dosage)

Pill Orgil is taken after meal, washing down with water. Schemes of treatment:

  • Trichomoniasis: on 1 tablet (500 mg) 2 times a day 5 days or a single dose of 3 tablets (1,5 g) for the night. For achievement of effect it is recommended to enter vaginal tablets in addition. The course of treatment of the sexual partner is obligatory.
  • Lambliasis: inside, on 3 tablets a day (1,5 g) 1-2 days.
  • Intestinal amebiasis: on 3 tablets (1,5 g) of 1 times a day three days.
  • Abenteric amebiasis: on 0,5 g (1 tablet) in 2 times a day 5-10 days.
  • Prevention of mephitic gangrenes: before an operative measure 2 times a day on 1-2 tablets (0,5 - 1 g) 3-4 days.

Overdose

Depression, spasms, neuritis peripheral.

Interaction

Drug strengthens effect of anticoagulants of a coumarinic row, exponentiates myorelaxation effect a bromide vekuroniya. At a concomitant use with other drugs — derivatives 5 nitroimidazoles — increase risk of development of a neuropathy, spasms as epilepsy, a depression.

Ornidazol does not interact with alcohol. Simultaneous reception with barbiturates, rifampicin reduces time of half-decay of an ornidazol. It is not recommended to accept drug with gematoksichny and neurotoxic HP.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years.

Orgil's analogs

Coincidence on the ATH code of the 4th level:

Meradazol, Meratin, Orzol, Ornivag 500, Ornigil, Ornidazol, Ornidzhil, Ornisid, Tiberal.

About Orgile

About drug favorable. Patients note that Orgil's use in complex treatment of infections of the urogenital sphere allows to recover completely.

Apteka24

  • Orgil of a tablet coated 500 mg No. 10kusum of Helskea (India)

BIOSPHERE

  • Оргил™ 500 mg No. 10 tabl.p.o.
to show still
Section: Gynecologic Antifungal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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