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Ornithine – diaminovaleric acid. Constitutional formula of a chemical compound: NH2CH2CH2CH2CH(NH2)COOH. In peptide sequences substance is designated by Orn. Means is present at a free look in live organisms, is a component of some antibiotics.
If to chip off from a molecule of diaminovaleric acid carbon oxide 4 (reaction happens during process rotting of a corpse), then it is formed putrestsin – one of the main components of ptomaine. L-ornithine (L-ornithine) is an optical isomer of this substance. For the first time it was synthesized from tissues of a liver of a shark in 1937. Amino acid represents colourless crystals which are easily dissolved in water and alcohol, and are difficult ether-soluble. The molecular mass of a chemical compound = 132,2 grams on mol. Annually in the world the 50th tone given lek is made near. means.
As a part of various drugs substance most often is in a type of ketoglutarate or aspartate.
Gepatoprotektivny, disintoxication, hypoazotemic.
Pharmacodynamics and pharmacokinetics
Ornithine takes part in urea synthesis processes (in an ornitinovy cycle), promotes utilization of ammonium groups, reduces concentration of ammonia in blood. Thanks to this drug KShchS of an organism is normalized and insulin is produced and With
If to use medicine at diseases which demand parenteral food it considerably improves protein metabolism.
After reception of means inside aspartate of ornithine dissociates on aspartate and ornithine which are quickly and completely soaked up in a small intestine by means of reactions of active transport through epithelial fabrics. Medicine through kidneys with urine is removed, during a mochevinoobrazovaniye cycle.
Indications to use
Drug is appointed:
- at a giperammoniyemiya;
- to patients with hepatitis or cirrhosis;
- at the latent or expressed hepatic encephalopathy;
- as a part of complex treatment of disturbances of consciousness (a prekoma and a coma) because of hepatic encephalopathy;
- as an additive to parenteral food for patients with proteinaceous insufficiency;
- for diagnosis, dynamic studying of work of a hypophysis.
L-ornithine is contraindicated to reception:
- at an allergy to this substance;
- to patients with the expressed renal failure (creatinine more than 3 mg on 100 ml).
Extra care is recommended to be observed to pregnant women and during a lactation.
Ornithine is well transferred. Can seldom arise: allergic enanthesis, vomiting, nausea. At emergence of an allergy it is recommended to see behind consultation a doctor.
Ornithine, application instruction (Way and dosage)
Means is appointed intravenously, inside or intramusculary.
For peroral use it is recommended to accept 3 grams of granulate which is previously dissolved in 200 ml of water or other neutral liquid. Frequency rate of reception of means – 2 or 3 times a day.
Intravenously medicine is appointed in the form of infusions. The dosing mode, frequency and duration of infusion depend on various parameters and are defined by the attending physician in an individual order. Usually 20 grams of substance dissolve in 500 ml of infusion solution. The maximum speed with which it is possible to enter medicine — 5 grams an hour. The maximum daily dosage makes 40 g.
There are no data on overdose by drug.
Medicine cannot be mixed in one syringe with diazepam and a benzatina benzylpenicillin.
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The recipe is not necessary.
If during intravenous administration of drug there is vomiting or nausea, then it is recommended to reduce infusion speed.
It is necessary to observe strictly compliance of a certain dosage form of drug to indications to reception.
It is recommended to be careful during driving of transport or performance of potentially dangerous types of activity. Drug can influence the speed of psychomotor reactions and cause disturbances of concentration of attention.
At pregnancy and a lactation
Only the attending physician according to direct indications can appoint medicine to pregnant women. It is recommended to stop breastfeeding as means is allocated with milk.
Drugs in which contains (Analogues)
Coincidence on the ATH code of the 4th level:
Responses on Ornithine
About drug use good. Medicine helps people with liver diseases normally to eat, there is an appetite, increases forces, quality of life of patients increases. Side reactions arise seldom. Drug is often used as a part of complex therapy.
Section: Active ingredients
PAY ATTENTION! Information on active ingredients on the website is help generalizing, collected from public sources and can form the basis for making decision on use of these substances it is not aware of treatment. Before substance Ornithine use surely consult with the attending physician.