Орнизол Drug photo

The description is actual on 20.07.2016

  • Latin name: Ornizol
  • ATH code: J01XD03
  • Active ingredient: Ornidazol (Ornidazole)
  • Producer: JSC Arterium Kiyevmedpreparat corporation (Ukraine); Novofarm-Biosintez (Ukraine)


Tablets: ornidazol, microcrystallic cellulose, low-molecular polyvinylpirrolidone, talc, calcium stearate, sodium carboxymethylstarch, granulak, Opadry Green.

Solution: ornidazol, sodium chloride, water sterile.

Release form

  • Tablets of green color, two-convex, coated 500 mg in the blister packaging in a cardboard pack No. 10.
  • Solution for infusions of 5 mg/ml in a glass bottle of 100 ml in a cardboard pack

Pharmacological action

Antiprotozoan, antibacterial.

Pharmacodynamics and pharmacokinetics


Active ingredient of Ornizol belongs to a derivative product 5 nitroimidazoles, has antiprotozoan and antibacterial effect. It is active concerning trichomonads, colibacillus, lyambliya, anaerobic cocci and a number of anaerobic bacteria (Clostridium spp., Bacteroides, Fusobacterium spp.).

Ornizol is DNK-tropnym the drug possessing selective activity to microorganisms with fermental systems which can recover nitrogroup and catalyze process of interaction of nitro compounds with proteins of group of ferridoksin. Active agent of drug at interaction with cellular structures of a microorganism under the influence of nitroreductases of a microorganism recovers nitrogroups. Products of recovery interact with DNA, destroying DNA replication processes. Products of a metabolism of Ornizol render cytotoxic effect, break cellular respiration of bacteria.


After intake Ornitozol quickly and almost completely (90%) is soaked up in a gastrointestinal tract. Cmax in blood is noted in 3 hours. Communication with blood proteins about 13%. Actively active ingredient of drug gets into all fabrics, bodies and liquids (saliva, bile, pleural liquid and SMZh, a vulval secret, a liver, a bone tissue, erythrocytes), including into breast milk. It is metabolized in a liver with formation of metabolites which possess considerably smaller pharmacological activity. An elimination half-life — about 13 h. Within five days it is removed with urine in the form of metabolites of 85% of a dose.

Indications to use

Tablets Ornizol

  • trichomoniasis, amebiasis, abenteric forms of an amebiasis, lambliasis;
  • prevention of mephitic postoperative gangrenes in gynecologic practice.

Solution for infusions

Its use is shown in cases of the acute infection proceeding in a severe form or if the condition of the patient does not allow to take a pill. It is applied at:

  • system mephitic gangrenes which activators are sensitive to an ornidazol: meningitis, peritonitis, septicaemia, postnatal sepsis, postoperative wound fevers, endometritis, septic abortion;
  • severe forms of amoebic dysentery, liver abscess, lambliasis, abenteric forms of an amebiasis.

It is shown for the prevention of development of mephitic gangrenes after operative measures.


High sensitivity to drug, an alcoholism, TsNS diseases (multiple sclerosis, epilepsy, organic lesions of a brain), diseases of blood and disturbance of blood circulation.

To take with caution to children of early age, at liver diseases.

Side effects

  • hypersensitivity reactions (itch, rash, urticaria);
  • oppression of processes of a marrowy hemopoiesis;
  • spasms, incoordination, rigidity, tremor, neuropathy, loss of consciousness, drowsiness, dizziness;
  • dispepsichesky frustration.

As varies side effects of drug of a dozozavisima, degree of their expressiveness over a wide range.

Ornizol, application instruction (Way and dosage)

Tablets — to accept after food, washing down with water.

Schemes of a drug dosing at trichomoniasis: to adults and children weighing over 35 kg — 3 tablets at one time; for children with body weight> 20 kg the dose in days is equal to 25 mg on 1 kg of weight. Treatment according to this scheme is not recommended to children weighing less than 35 kg.

For an exception of repeated infection it is necessary to treat the sexual partner.

Schemes of a drug dosing at an amebiasis: the adult at amoebic dysentery — 3 tablets on reception once three days; weighing more than 60 kg — on 2 tablets two times a day. To children with a weight> 25 kg — 2 tablets for 1 reception once; at an amebiasis of other forms the adult — 2 tablets a day for 2 receptions for 5 days; to children with a weight> 35 kg — 2 tablets in 1 reception.

Schemes of a drug dosing at a lambliasis: to adults and children weighing over 35 kg — on 3 tablets once.

Solution — to enter intravenously slowly within 15–30 minutes.

For treatment of a mephitic gangrene by the adult appoint drug in an initial dose of 500-1000 mg, in the subsequent — on 500 mg in 12 hours or on 1000 mg in 24 hours for 5-10 days. After stabilization of a state it is necessary to transfer the patient to oral administration of drug. With the preventive purpose — 500-1000 mg for half an hour to surgical intervention. In cases of prevention of multi-infections to apply along with purpose of cephalosporin or penicillin. To administer the drugs separately.

For treatment of amoebic dysentery and abenteric forms of an amebiasis originally to enter 500-1000 mg, in the subsequent — on 500 mg in 12 hours on an extent within 3-5 days.


It is shown by symptomatology similar to side effects, but in more expressed form.


Drug is compatible to alcohol, strengthens effect of anticoagulants, prolongs action a bromide vekuroniya. At administration of drug with other HP, derivatives 5 nitroimidazoles, the depression, peripheral neuritis can develop.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 25 °C.

Period of validity

2 years.


Coincidence on the ATH code of the 4th level:

Avrazor, Ornidazol, Gayro, Dazolik, Ornidazol-Vero, Lornizol, Ornisid and others.

About Ornizole

About drug in most cases positive. Ornizol allows to achieve good effect at a trichomoniasis at any stage (acute, torpid, chronic, and also in trikhomonadonositelstvo cases.


  • Ornizol No. 10kiyevmedpreparat tablet 0.5g (Ukraine, Kiev)


  • Ornizol solution for inf. 5mg/ml bottle of 100 ml No. 1kiyevmedpreparat


  • Ornizol of 500 mg No. 10 tabl.p.o.
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Section: Gynecologic
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Ornizol surely consult with the attending physician.