Овенкор Drug photo

The description is actual on 01.07.2016

  • Latin name: Ovenkor
  • ATH code: C10AA01
  • Active ingredient: Simvastatin (Simvastatin)
  • Producer: LLC OZON (Russia)


Simvastatin, ascorbic acid, butylhydroxyanisole, citric acid, lactose, gelated starch, microcrystallic cellulose, titanium dioxide, magnesium stearate, corn starch, castor oil, gidroksipropilmetiltsellyuloz, polyethyleneglycol, talc.

Release form

Mg tablets 10 and 20 round in a film cover of white color biconvex in planimetric packaging in a cardboard pack No. 10, 20, 50.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Drug from group of statines, possesses hypolipidemic action, inhibits GMG-KOA-reduktazu. Its structure has the closed lactonic ring which in a human body is hydrolyzed, that is is pro-medicine.

The lactonic ring of statines has affinity with enzyme GMG-KOA-reduktaza therefore competitively contacts part of a receptor of coenzyme A where this enzyme is attached.

The part of a molecule of statine participates process of transformation of hydroxymethylglutarate in mevalonat which belongs to a product of intermediate synthesis of a molecule of cholesterol. These processes cause a number of reactions as a result of which the intracellular content of cholesterol decreases also acceleration of a catabolism of LPNP cholesterol. The hypolipidemic effect of drug is caused by decrease in level of the general cholesterol at the expense of LPNP cholesterol. At the same time, decrease in the LPNP level dozozavisimo also has exponential character.

Statines do not influence a catabolism and synthesis of free fatty acids therefore they influence the TG level is mediated (for the second time). According to researches drug increases LPVP-cholesterol level to 14%. Except hypolipidemic action, drug exerts positive impact on a vascular wall at endothelium dysfunction (a sign of preclinical display of early atherosclerosis), normalizes rheological properties of blood, has anti-proliferative and antioxidant effect. Treatment by drug is followed by decrease in frequency of cardiovascular disturbances.


Drug is almost completely absorbed from a gastrointestinal tract. The maximum concentration is reached in 4 hours. Meal does not influence pharmacokinetic parameters. Linkng with blood proteins — high. Biotransformation of a simvastatin happens in a liver to formation pharmacological of active beta metabolites. No more than 5% of all concentration of a metabolite of a simvastatin come to a system blood stream. Drug, both in not changed look, and in the form of metabolites, mainly with bile and to a lesser extent kidneys is removed.

Indications to use

  • Hypercholesterolemia (primary) — at an inefficient low-cholesteric dietotherapy and non-drug actions (weight reduction, an exercise stress) at patients with the increased risk of development of coronary atherosclerosis;
  • Coronary heart disease;
  • Combined gipertriglitseridemiya / the hypercholesterolemia which is not giving in to correction by a diet and an exercise stress;
  • With the preventive purpose (reduction of risk of death at a myocardial infarction, risk of development of disturbances of cardiovascular system (ischemic attacks, a stroke), atherosclerosis of coronary vessels.


High sensitivity to drug, a porphyria, liver diseases, age till 18 flyings, diseases of skeletal muscles, pregnancy and the period of a lactation.

To appoint with care to the patients who transferred an organ transplantation and accepting immunodepressants, abusing the alcohol having endocrine diseases and disturbances of a metabolism at epilepsy, arterial hypotension, acute infectious diseases.

Side effects

Appetite loss, lock, diarrhea, nausea, meteorism, abdominal pains, pancreatitis; dizziness, headache, paresthesias, muscular spasms; arterial hypotension; myopathy, mialgiya, allergic reactions, photosensitization, dermahemia, itch, skin rash, anemia.

Ovenkor, application instruction (Way and dosage)

Before therapy by Ovenkor, to the patient the standard hypocholesteric diet is appointed to the entire period of treatment. To accept drug once a day in the evening, washing down with water. Administration of drug should not be connected with meal. The recommended daily dose for treatment of a hypercholesterolemia fluctuates within 10 — 80 mg. At the same time, the initial dose makes 10 mg. Changes of a dose to be carried out bucketed in one month. At overwhelming number of patients the optimum medical effect comes at Ovenkor's reception in daily doses to 20 mg.

For patients with an ischemic heart disease or its high risk of development effective daily doses of drug make 20-40 mg, and initial — 20 mg a day. Dose adjustment to patients after 60 flyings and the patient with easy or average degree of a renal failure is not carried out. At a concomitant use of Ovenkorom and Verapamil or Amiodaronum the daily dosage of Ovenkor should not be more than 20 mg.


The specific clinically expressed symptoms of overdose are not revealed.


Simvastatin strengthens effect of peroral anticoagulants (warfarin, fenprokumon) and increases probability of developing of bleedings therefore control of coagulability of blood before administration of drug, and also in an initial stage of treatment is necessary. Bioavailability of drug decreases at a concomitant use of Kolestipol and Colestyraminum. Juice at Simvastatin's reception, is not recommended the use of grapefruit juice in volume more than 1 liter a day because of high risk of increase in level of the inhibiting activity in a GMG-KOA-reduktazy blood plasma.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

3 years.

Ovenkor's analogs

Avestatin, Aterostat, Vero-Simvastatin, Aktalipid, Zokor, Vazilip, Zovatin, Simvageksal, Simvakol, Simvastatin, Levomir, Simvalimit, Zorstat, Simvakard, Simvastol, Simplakor, Simvor, Sinkard, Simgal, Simlo, Holvasim.

About Ovenkore

About drug differ. Some patients note good effect: "… Ovenkor spent on drink medicine, the indicator of cholesterol decreased with 7,2 to 4,8. But I at the same time kept also to the diet appointed to me". Other patients complain of fast development of side effects in this connection they are forced to stop administration of drug: "… From the first tablet of Ovenkor to me it became bad, and I pulled out. I do not know how to continue treatment"; "… When I drank Ovenkor, I had an awful state therefore the doctor cancelled it and appointed only a diet".


  • Ovenkor of 20 mg No. 30 of a tablet
  • Ovenkor of 10 mg No. 30 of a tablet
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Section: Cardiovascular
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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