Palinum

Палин Drug photo

The description is actual on 29.12.2014

  • Latin name: Palin
  • ATH code: J01MB04
  • Active ingredient: Acid pipemidovy (Acid pipemidic)
  • Producer: LEK d.d. (Slovenia)

Structure

  • 200 mg of pipemidovy acid are a part of one capsule of Palinum. Additional components: silicon dioxide, starch, magnesium stearate. Structure of a cover of a capsule: yellow dye sunset, titanium dioxide, gelatin. Structure of a cover of a capsule: yellow dye quinolinic, titanium dioxide, yellow dye decline solar, blue dye, black dye diamond, gelatin.
  • The structure of one tablet Palinum, coated, includes 400 mg of pipemidinovy acid.
  • 200 mg of pipemidinovy acid are a part of one vaginal candle of Palinum.

Release form

  • Capsules of white or white-yellow color with a lid of green color; inside – white or light yellow powder.
    10 such capsules in the blister; two blisters in a box of paper.
  • Candles are issued on 10 pieces in a strip; one strip plate in a box of paper.
  • Tablets are issued on 20 pieces in a bottle; one bottle in a box of paper.

Pharmacological action

Possesses antibacterial action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antibacterial medicine, belongs to hinolona. Possesses bactericidal action. Medicine is active concerning gram-negative microorganisms: Enterobacter spp., Proteus vulgaris, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Neisseria spp.; and gram-positive microorganisms: Staphylococcus aureus.

Drug does not possess activity in relation to anaerobic bacteria.

Pharmacokinetics

After reception of 400 mg of drug the maximum concentration of pipemidovy acid is registered in 75-80 minutes. Bioavailability averages 30-60%. In urine, kidneys and a secret of a prostate high concentration of drug come to light. Passes through a gematoplatsentarny barrier. Pipemidova acid is capable is emitted in a small amount with breast milk.

It is removed with urine in an original form. The elimination half-life makes 2 hours.

Indications to use

The inflammatory damages of urinary tract of both acute, and chronic character caused by sensitive activators:

The prevention of infectious infection in gynecology and urology at tool interventions.

Contraindications

Side effects

  • Reactions from the hemopoietic system: persons with a lack of enzyme glyukozo-6-fosfatdegidrogenazy can have a hemolitic anemia; at elderly persons and persons with changes of function of kidneys emergence of thrombocytopenia is possible.
  • Reactions from a nervous system: the headache, a tremor, visual disturbances, frustration of a dream, excitement, a depression, hallucinations, touch disturbances, spasms, is more rare convulsive attacks.
  • Reactions from system of digestion: gastralgia, nausea, pseudomembranous colitis, diarrhea, vomiting.
  • Allergic reactions: small tortoiseshell, Stephens-Johnson's syndrome.
  • Other reactions: superinfection, a photosensitization, resistance development is possible.

Application instruction of Palinum (Way and dosage)

Palinum, the application instruction advises candles to women at infections of an urinogenital path together with tablets or capsules to accept on 1 vaginal candle in the evening within one and a half weeks.

The tablets Palinum and capsules the application instruction recommends to accept on 200 mg of drug in the evening and in the morning before a breakfast and a dinner.

At staphylococcal defeats time between receptions of means should not exceed 8 hours. The course of therapy lasts on average one and a half weeks. If necessary it can be increased depending on clinic and the course of a disease.

At damages of kidneys the course of therapy can reach 6 weeks, at a prostate inflammation — 8 weeks. During treatment the patient is recommended to drink more.

Overdose

There are no messages on development of the expressed side effects or death at overdose by Palinum.

Symptoms: vomiting, nausea, dizziness, confusion of consciousness, tremor, headache, spasms.

Treatment: the antidote is unknown, a gastric lavage, the use of absorbent carbon. At emergence of spasms recommend Dto iazepa.

Interaction

Pipemidovy acid brakes a metabolism of theophylline and caffeine.

Joint reception of antacids and sukralfat suppresses adsorption of pipemidovy acid, exposure by receptions of these drugs has to be less than three hours.

Pipemidovy acid activates effects of rifampicin, Cimetidinum, warfarin and non-steroidal anti-inflammatory drugs.

At combined use with aminoglycosides the synergism of antibacterial action is revealed.

Terms of sale

According to the recipe.

Storage conditions

  • To store in the dry place at a temperature up to 25 degrees.
  • To protect from children.

Period of validity

Five years.

Special instructions

With care to use drug to the persons having in the anamnesis of change of cerebral blood circulation, a spasm, to persons 70 years are more senior.

As at reception of Palinum the photosensitization is possible, during treatment it is necessary to limit itself from ultra-violet radiation.

It is not necessary to use this medicine at children. Pipemidovy acid can collect in cartilaginous tissue.

When using drug it is recommended to abstain driving of the car.

Analogs of Palinum

Coincidence on the ATH code of the 4th level:

Analogs of drug: Vero-Pipemidin, Pimidel, Pilamin, Pipegal, Pipem, Pipelin, Uropimid, Pipemidovaya acid, Urotraktin.

Zdravzona

  • Palinum of 200 mg No. 20 kapsulysoteks Farmfirma of closed joint stock company

Drugstore of IFC

  • Palinum kaps 200 mg No. 20, Lek/of Soteks (г.Москва) Russia
  • Palinum kaps 200 mg No. 20, Leksloveniya
to show still

Apteka24

  • Palin20

BIOSPHERE

  • Palinum of 200 mg No. 20 kaps.
to show still
Section: Antibiotics Urological
in more detail

Education: Graduated from the Vitebsk state medical university majoring in "Surgery". At university headed Council of students' scientific society. Professional development in 2010 - in "Oncology" and in 2011 - in "A mammology, visual forms of oncology".

Experience: Work in an all-medical network 3 years the surgeon (The Vitebsk hospital of an emergency medical service, Lioznensky TsRB) and in combination the regional oncologist and the traumatologist. Work farm the representative within a year in the Rubicon company.

Provided 3 improvement suggestions on the subject "Optimization of an Antibioticotherapia depending on Species Composition of Microflora", 2 works took prizes in a republican competition review of student's scientific works (1 and 3 categories).
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Palinum surely consult with the attending physician.