Panadolum

• Structure
• Release form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications to use, from what the tablet Panadolum
• Contraindications
• Side effects
• Application instruction of Panadolum (Way and dosage)
• Overdose
• Interaction
• Terms of sale
• Storage conditions
• Period of validity
• Special instructions
• Analogs
• To children
• At pregnancy and a lactation
• Responses
• The price where to buy

Structure of Panadolum

The tablet contains 500 mg of paracetamol in a special film cover. Additional components: povidone, potassium sorbate, corn starch, triacetin, prezhelatinizirovanny starch, gipromelloza, stearic acid, talc.

Structure of a soluble tablet: 500 mg of active agent and additional components: dimetikon, sodium lauryl sulfate, povidone, sodium carbonate, citric acid, hydrosodium carbonate, sodium saccharinate, sorbitol.

Release form

Panadolum is issued in the tableted look: the soluble tablets Panadolum and tablets in a film cover.

Soluble tablets have the white color, the flat form, a rough surface mown around edge and to risk on one of the parties.

Tablets in a film cover have the kapsulovidny form, flat edges, a white color, to risk on one of the parties and a special stamping of "Panadol" on other party.

Pharmacological action

Antipyretic analgetic. The operating component possesses febrifugal, anesthetizing effects. The principle of influence is based on blocking of TsOG-1,2 mainly in the central part of the nervous system. Active component influences the centers of thermal control and pain.

The antiinflammatory effect at Paracetamol is almost not expressed. Active component does not make the irritating impact on mucous membranes of a digestive tract (intestines, a stomach). Panadolum is not capable to influence process of synthesizing of prostaglandins in peripheral located fabrics therefore the medicine does not influence a water salt metabolism.

Pharmacodynamics and pharmacokinetics

The medicine is quickly absorbed from a gleam of a digestive tract by means of passive transport. Active component is soaked up mainly from a small intestine. The maximum concentration of paracetamol after a single dose of 500 mg is registered in 10-60 minutes (With (max) of =6 mkg/ml). In 6 hours the indicator smoothly reaches the level of 11-12 mkg/ml.

Hypodispersion in fluid mediums and body tissues is characteristic of active ingredient, without getting to cerebrospinal fluid and fatty tissue.

The indicator of linkng with plasma proteins does not exceed 10%, slightly increasing at overdose. Glyukuronidny and sulphatic metabolites are not capable to contact plasma proteins even in rather high dosages. Panadolum is metabolized mainly in hepatic system due to conjugation with sulfate and a glucuronide, and also due to oxidation with participation of P450 cytochrome and the mixed hepatic oxidases.

The N-acetyl-r-benzokhinonimin (a hydroxylated metabolite with negative effect) formed in renal and hepatic systems in small amounts as a result of interaction of the mixed forms of oxidases is detoxified due to linkng with glutathione. At overdose there is an accumulation N-acetyl-r-benzokhinonimina that can cause damage of fabrics. The considerable part of paracetamol contacts glucuronic acid, insignificant — sulphuric acid. The listed conjugated metabolites does not make biological impact and do not possess activity. The metabolism with formation of sulphatic metabolites is characteristic of newborn and premature children.

The elimination half-life is equal to 1-3 h. At cirrhotic defeat of the hepatic T1\2 system considerably increases. The renal clearance reaches an indicator of 5%. Through renal system the medicine is removed with urine in the form of sulphatic and glyukuronidny conjugates. In an invariable look less than 5% of paracetamol are removed.

Indications to use, from what the tablet Panadolum

Medicine is used for symptomatic therapy and stopping of a pain syndrome:

• painful periods;
• muscular pains;
• headaches;
• pain at burns;
• dentagra;
• migraine;
• posttraumatic pain;
• algodismenoreya;
• dorsodynia, waist;
• pharyngalgia.

As an antipyretic (a feverish syndrome) drug is appointed at the increased body temperature (cold, flu, an infection). Medicine does not exert impact on progressing and a current of a basic disease and is applied only to reduction of expressiveness of painful symptomatology.

Contraindications

At individual hypersensitivity Panadolum is not appointed. Age restriction – till 6 flyings.

Relative contraindications:

• Gilbert's syndrome;
• liver failure;
• high-quality hyperbilirubinemia;
• alcoholic defeat of hepatic system;
• renal failure;
• pregnancy;
• viral hepatitis;
• advanced age;
• deficit glyukozo-6-fosfatdegidrogenazy;
• alcoholism;
• breastfeeding.

Side effects

Panadolum is well transferred in the dosages recommended by the producer.

Negative changes from an urinary system:

• intersticial nephrite;
• renal gripes;
• papillary necrosis;
• nonspecific bacteriuria.

Other reactions:

• anemia;
• neutropenia;
• skin rashes;
• Quincke's edema;
• agranulocytosis;
• dispepsichesky phenomena;
• thrombocytopenia;
• skin itch;
• methemoglobinemia;
• hepatotoxic influence, damage of a liver.

Application instruction of Panadolum (Way and dosage)

Usual tablets Panadolum, application instruction

The adult appoint on 500-1000 mg to 4 times a day if necessary. The recommended time interval between receptions – 4 hours. In days it is possible to take no more than 8 pill. Prolonged use of Panadolum as anesthetic (at most 5 days) and febrifugal (no more than 3 days) means is not allowed. The decision about increase in a daily dosage or duration of therapy is accepted by the treating doctor.

Sparkling tablets Panadolum, application instruction

Tablets before use dissolve in a glass with water. In days it is possible to take no more than 4 pill. Soluble Panadolum is appointed mainly at difficulty of swallowing of tablets and in pediatric practice.

Overdose

The producer recommends to accept a medicine only in the dosages specified in the instruction. At reception of the raised doses the immediate request for medical care, even in the absence of negative symptomatology since perhaps delayed defeat of hepatic system is required. At adult patients the first signs of injury of a liver are observed at reception more than 10 grams of a medicine. Reception more than 5 grams exerts toxic impact at a certain category of the citizens having risk factors:

• the use of alkogolsoderzhashchy drinks in large numbers and with high frequency;
• reception of Phenytoinum, Phenobarbital, Carbamazepine, Rifampicin, Primidonum, drugs of the St. John's Wort which is made a hole and other medicines stimulating production of liver enzymes;
• deficit of glutathione (at HIV infection, a mucoviscidosis, bad food, exhaustion and starvation).

Symptoms of poisoning:

• the strengthened sweating;
• nausea;
• epigastric pains;
• pallor of integuments;
• vomiting.

At a serious poisoning the acute renal failure, arrhythmia, encephalopathy, a coma, a tubular necrosis, pancreatitis can develop.

Treatment includes a gastric lavage, use of enterosorbiruyushchy medicines (Polyphepanum, Absorbent carbon), introduction of predecessors of synthesis of glutathione-methionine and donators of SH groups. At the expressed defeats of hepatic system treatment is carried out under the leadership of specialists of the toxicological center.

Interaction

The risk of hepatotoxic defeat increases at simultaneous treatment by inductors of the microsomal liver enzymes and medicines showing hepatotoxic influence. Moderately expressed or slight increase of an indicator of a prothrombin time is registered.

Absorption of Paracetamol decreases at purpose of anticholinergic medicines. Expressiveness of analgetic effect goes down, and removal accelerates at treatment by oral contraceptives. Paracetamol suppresses activity of uricosuric drugs. The indicator of biological availability of Panadolum decreases at reception of Absorbent carbon. Decrease in excretion of Diazepam is registered.

Concerning the Zidovudine strengthening of miyelodepressivny effect is observed. In medical practice 1 case of crushing toxic defeat of hepatic system is registered. Toxic effects amplify at reception of the Isoniazid. Acceleration of a metabolism (oxidation, a glyukuronization) of Paracetamol and decrease in its efficiency at simultaneous use of the following medicines is observed:

• Phenytoinum;
• Carbamazepine;
• Primidonum;
• Phenobarbital (the hepatotoxic amplifies).

Colestyraminum slows down Paracetamol absorption (at non-compliance with a time interval between receptions at 1 o'clock). Panadolum accelerates Lamotridzhin's removal. Metoclopramidum increases concentration of Paracetamol in blood, increasing its absorption. Probenetsid reduces clearance of Panadolum. The converse effect is observed with the relation of Sulfinpyrazonum and Rifampicin. Ethinylestradiol strengthens absorption of a medicine from an intestines gleam.

Terms of sale

It is released in specialized points, drugstores at presentation of the prescription form of the doctor.

Storage conditions

The producer recommends to maintain temperature condition (to 30 degrees) for preservation of efficiency of a medicine during all term specified on packaging.

Period of validity

5 years.

Special instructions

The producer recommends carrying out periodic control over blood indicators. At reception of holesterinsnizhayushchy drugs (Colestyraminum), antiemetics (Domperidon, Metoclopramidum), at pathology of renal/hepatic system respect for care is required.

Frequent use of Panadolum in need of daily reception of anticoagulating drugs is not allowed. It is necessary to notify the treating doctor on reception of Paracetamol when carrying out the analysis on the level of sugar and uric acid in blood. Reception of alkogolsoderzhashchy drinks is inadmissible during treatment. With care appoint to the persons suffering from an alcoholism.

Analogs

• Paracetamol;
• Efferalgan;
• Prokhodol;
• Perfalgan;
• Tsefkon D.