Papaverine

Папаверин Drug photo

The description is actual on 06.01.2015

  • Latin name: Papaverine
  • ATH code: A03AD01
  • Active ingredient: Papaverine hydrochloride (Papaverine hydrochloride)
  • Producer: JSC Biosintez, JSC Dalkhimfarm (Russia), Borisovsky ZMP (Belarus)

Structure

Solution for injections:

  • papaverine a hydrochloride — 20 mg on 1 ml of medicinal liquid;
  • D, L-methionine;
  • dinatrium edetat;
  • water for injections.

Tablets:

  • papaverine a hydrochloride — 10 mg in 1 tablet;
  • refined sugar;
  • potato starch;
  • stearic acid;
  • talc.

Rectal suppositories:

  • papaverine a hydrochloride — 0,02 g in 1 candle weight in 1,25 g;
  • emulsifier No. 1;
  • stearin cosmetic;
  • solid fat.

Release form

  • Papaverine in tablets on 0,01 g or 0,04 g, depending on target audience of patients (the first are used in pediatric practice after 6 months), which are packed up in planimetric cell blisters on 10 pieces. The peroral form has slightly bitterish taste, white color and has no smell at all.
  • Solution for injection introduction of 2% in ampoules on 2 ml. Cardboard packaging, as a rule, contains 10 pieces and the application instruction of pharmaceutical drug.
  • Rectal suppositories or candles for introduction to a rectum on 0,02 g everyone; fixed in blisters from PVC or aluminum foil on 10 pieces. The plate with medicine and the summary keeps within a cardboard box.

Pharmacological action

Papaverine the hydrochloride (Wikipedia specifies that MNN of drug corresponds to the name of the main active component) is the opium alkaloid influencing smooth muscle elements and the causing their relaxation therefore the pharmacological group of medicine is defined how myotropic spasmolysants.

The mechanism of therapeutic effect of biological substance consists in influence on secondary intermediaries (messengers) of transfer of muscular excitement. The papaverine is inhibited FDE (phosphodiesterase) at the expense of what in a cell tsAMF (cycloadenosinemonophosphate) collects and the maintenance of calcium ions decreases, in response to such biochemical changes unstriated muscles of internals (a digestive tube, respiratory and urinogenital systems and a vascular bed) relax, their tone decreases.

The pharmacopeia is the set of obligatory rules and official regulations by which are guided at production, check, storage and appointment of medicines as the patient. As the main biologically active component of pharmaceutical drug is strong, concerning the Papaverine a hydrochloride the pharmacopeia includes the following items of determination of authenticity of chemical:

  • Physical characteristics – inodorous white crystal powder, with poorly bitter taste.
  • Solubility – in water is dissolved for 40 hours, we will dissolve in 95% alcohol a little, we will dissolve in chloroform and is practically not ether-soluble.
  • Acidity of 2% of solution of the Papaverine of a hydrochloride – 3,0-4,5 (is defined by an electrometric way).
  • Chemical control of authenticity – 0,05 g of pharmaceutical drug place in a porcelain bowl, moisten with couple of drops of nitric acid of high concentration then there has to be a yellow coloring which when heating on the water bath changes to orange.
  • Availability of organic impurity – the test of dissolution and change of coloring in 5 ml to concentrated sulphuric acid.

Pharmacodynamics and pharmacokinetics

The operating component is quickly and almost completely soaked up at any ways of administration of medicine to an organism. Getting to a circulatory bed, contacts proteins of plasma (90% of all biologically active agent) thanks to what easily passes through gistogematichesky barriers. Is exposed to biotransformation in a liver. The elimination half-life makes of 30 minutes till 2 o'clock, depending on auxiliary components of pharmaceutical drug. It is removed mainly by kidneys in the form of products of a metabolic exchange.

Indications to use of the Papaverine

  • spasm of unstriated muscles of abdominal organs (it is especially frequent at cholecystitis, a spastic colitis or a pylorospasm);
  • hypertensive crisis (in the combined conservative therapy);
  • renal colic;
  • endarteritis;
  • spasm of a peripheral vascular bed;
  • reduction of a gleam of vessels of a brain owing to reduction of a muscular layer of arteries;
  • stenocardia;
  • bronchospasm;
  • reduction of arterial renal inflow of vascular genesis;
  • ischuria owing to a spasm of urinary tract.

Indications to use also include a premedication stage before operational surgical interventions in an abdominal cavity, proctologic and urological manipulations. What apply to – relaxation of smooth muscle elements (for more details see in the Pharmacological Action point).

Contraindications

  • intolerance of the making medicine components;
  • disturbances of endocardiac conductivity, especially atrioventricular block;
  • hypersensitivity to pharmaceutical drug;
  • glaucoma;
  • heavy liver failure;
  • advanced age (as there is a great risk of development of a hyper thermal syndrome);
  • children's age till 6 months.

Additional restrictions to use (it is recommended to use only under continuous supervision of the qualified health workers and regular diagnostic inspections):

Side effects

  • From cardiovascular system and blood: atrioventricular block, ventricular tachycardia, lowering of arterial pressure.
  • From a digestive tract: nausea, a konstipation (lock), abdominal distention, disturbance of a passage on a digestive tube, increase of activity of hepatic transaminases.
  • Others: drowsiness, allergic reactions, eosinophilia.

Application instruction of the Papaverine (Way and dosage)

Tablets Papaverine, application instruction

In tablets pharmaceutical drug can be appointed to both adults, and children, even frequency rate of reception does not change and makes 3-4 times a day. The dosage of a peroral form of medicine depends on an age category of the patient, use the following scheme of treatment:

  • from 6 months to 2 flyings – 0,005 g on reception;
  • 3-4 years – 0,005-0,01 g;
  • 5-6 years – 0,01 g;
  • 7-9 years – 0,01-0,015 g;
  • 10-14 years – 0,015-0,02 g;
  • the adult – for 0,04-0,08 on reception.

Candles Papaverine, application instruction

Hemorrhoids are extremely unpleasant proctologic disease which is connected with thrombosis, inflammatory processes and pathological expansion of the hemorrhoidal veins surrounding a rectum exit gleam. This nosological unit the typical clinical picture which includes defecation disturbance, an itch, bleedings from an anus is inherent. Candles with the Papaverine will help to facilitate the course of a disease.

The operating components pharmaceutical drug allow to weaken smooth muscle elements of intestines that facilitates process of an excrement, the rectum gleam increases a little. Bleedings as firm fecal masses does not injure the inflamed hemorrhoidal nodes therefore candles with the Papaverine at hemorrhoids are peculiar "magic wand" are for the same reason stopped.

It is possible to find suppositories with a different dosage of biologically active agent in pharmaceutical booths. It is necessary to begin a course of conservative sanitation with 0,02 g, gradually increasing it to 0,04 g if the smaller amount of pharmaceutical drug has no therapeutic effect. It is not recommended to use more than 3 candles a day, it is fraught with development of adverse side effects and even a condition of overdose as in rectal area all arriving medicines are extremely well soaked up.

How to use injection solution of the Papaverine of the Hydrochloride?

The operating component of pharmaceutical drug possesses high bioavailability therefore injections can be done, both subcutaneously and intramusculary, and intravenously, therapeutic opportunities of medicine will not suffer from it, and the net result will be so strong. It is necessary to be defined however that the application instruction recommends to give hypodermic injections of the Papaverine of a hydrochloride not in distal part of a forearm, and in a shoulder or in an outside surface of a hip as frequency rate of introduction can provide emergence of a hematoma. Intramuscular pricks of the Papaverine can be carried out according to the standard scheme, that is to use an upper lateral quadrant of a buttock.

Before making intravenous pricks, the amount of pharmaceutical drug appointed by the doctor should be diluted with 10-20 ml of isotonic solution of sodium of chloride. Also it is necessary to remember that it is necessary to enter the Papaverine a hydrochloride very slowly not to cause in the patient unpleasant feelings in the course of an injection.

Subcutaneously contents of 1 ampoule (2 ml) of 2% of solution of the Papaverine of the Hydrochloride are, as a rule, entered.

Solution dosage in ampoules at intravenous and intramuscular administration:

  • adult: one-time – 0,1 g, daily – 0,3;
  • to children from 6 months to 1 year: one-time – 0,005 g, daily – 0,01 g;
  • at the age of 2 flyings: one-time – 0,01 g, daily – 0,02 g;
  • 3-4 years: one-time – 0,015 g, daily – 0,03 g;
  • 5-6 years: one-time – 0,02 g, daily – 0,04 g;
  • 7-9 years: one-time – 0,03 g, daily 0,06 g;
  • 10-14 years: one-time – 0,06-0,06, daily – 0,1-0,2 g.

Dibazolum with the Papaverine — how to use?

Dibazolum is an anti-hypertensive medicine from group of peripheral vazodilatator, that is the operating components of pharmaceutical drug exert vasodilating impact and considerably promote lowering of arterial pressure. The papaverine possesses similar therapeutic properties concerning vascular system therefore the combination of these medicines is actively used by workers of an emergency medical service for elimination of hypertensive crisis.

Dibazolum with the Papaverine intramusculary or intravenously is entered, thus necessary pharmacological effects of the operating components develop much quicker, than at peroral or any other way of use. The weakening influence of biologically active components can be combined with physiotherapeutic methods, for example, horizontal position with the lowered foot end, heat baths for legs, massage of the lower extremities and so on.

Dibazolum dosage with the Papaverine for elimination of hypertensive crisis makes 3-5 ml of 1% of solution of Dibazolum and 2 ml (contents of 1 ampoule) of 2% of solution of the second pharmaceutical drug. Such large number of the operating components allow not only to reduce arterial pressure, but also to stop feeling of nausea, painful feelings in heart and some other displays of cardiovascular pathology.

Overdose

Possible symptoms at intoxication the operating medicine components:

  • diplopia (doubling in eyes);
  • weakness;
  • lowering of arterial pressure;
  • drowsiness;
  • increased fatigue.

There is no specific pharmaceutical antidote therefore disintoxication therapy and a symptomatic treatment is applied. The gastric lavage or the use of sorbents (milk, absorbent carbon, for example) during the first hours after reception of peroral forms of the Papaverine of a hydrochloride is especially effective. Also at overdose by medicine it is important to monitorirovat constantly and, if necessary, artificially to support arterial pressure.

Interaction

Platyphyllinum is spasmolytic, vazodilatiruyushchy, a sedative, that is on pharmacological abilities close to the Papaverine. Medicines only in mechanisms of therapeutic action therefore Platyphyllinum with the Papaverine are applied in the combined conservative sanitation of spastic syndromes, hypertensive crises and other morbid conditions differ.

Nospanum with the Papaverine, as well as Platyphyllinum, interact well, exerting synergistic therapeutic impact on smooth muscular elements of a human body. Such combination of pharmaceutical drugs especially often meets in obstetric and gynecologic hospitals at a uterus tone, threat of a spontaneous abortion or excessively vigorous early patrimonial activity.

In medical editions of neurologic subject there are news that efficiency of use of the Levodopa considerably decreases in the combined conservative therapy from what or in the form of solution for injections against medicamentous sanitation of an illness of Parkinson it is contraindicated to use the Papaverine in tablets.

Simultaneous use of the Papaverine with anticholinergic medicines can be shown in strengthening of therapeutic effects of the last therefore in need of their combined use it is necessary to discuss reduction of dosages or temporary cancellation of pharmaceutical drugs with the qualified specialist.

Terms of sale

Pharmaceutical drug is known from time immemorial and was always famous for force of the therapeutic action therefore earlier in pharmaceutical booths upon its purchase the recipe on Latin was required. Nowadays procedure of acquisition of the Papaverine became far easier, however to show the recipe which is correctly issued and certified by the attending physician – the patient's duty.

Storage conditions

In the dry, protected from direct beams of a sunlight place at temperature condition it is not above 25 degrees Celsius in densely packed container. Pharmaceutical drug belongs to the list B therefore it is necessary to monitor its storage carefully.

Period of validity

2 years.

Special instructions

Papaverine the hydrochloride considerably improves peripheric circulation that provides improvement of trophic processes in separate bodies at its local use. This therapeutic ability causes use of pharmaceutical drug in bodybuilding. Practical supervision of athletes show that it is the most effective to use medicine for increase in specific weight deltoid and a biceps.

The purpose of athletes is local impact on a certain part of muscles from what pricks are carried out intramusculary. The optimum dosage makes 1-2 injections a week which are carried out in 15-20 minutes before intensive training. Further, at the very beginning of physical exercises, all efforts should be aimed at the "enriched" muscle, that is to be engaged on system of "pamping" (blood inflating) as the therapeutic effect of the Papaverine at local use is short.

The ingenuity and resourcefulness of a female half of mankind does not lag behind the stronger sex at all, the Papaverine the hydrochloride is applied even in cosmetology procedures and home care of integuments. Thanks to the strengthened blood circulation of peripheral body parts under the influence of pharmaceutical drug, removal of the accumulated liquid improves, puffiness is removed and exchange processes are somewhat stimulated. Such therapeutic effects allow to use medicine for fight against cellulitis, elimination of unpleasant "orange-peel" in buttocks and a back surface of a hip and even to disposal of couple of extra kilos.

The leading cosmetologists recommend to apply a wrapping to receiving such result caffeine and the Papaverine which can be carried out even in house conditions. To prepare miracle mix, 2 ampoules of Caffeine of benzoate on 2 ml, 2 ampoules of the Papaverine of a hydrochloride on 2 ml and a small amount of not become candied honey will be required. Before putting cosmetic it is necessary to prepare integuments what apply an easy peeling, a srub or small local massage to.

Mix should be applied evenly on all site of the processed surface with a small layer. At once cosmetic will not be absorbed therefore it is necessary to cover densely integuments with a polyethylene film (food wrap is ideally suited for these purposes) and to be warmed, having muffled in a wadded blanket or by means of winter clothes. Not less than an hour is recommended to carry out a wrapping then to wash away the mix remains warm water and to apply the moisturizing or feeding cream. Duration of a course makes twelve procedures, and the frequency of their carrying out – every other day.

The operating components of pharmaceutical drug extend the beneficial effects not only to people, but also to animals therefore the Papaverine found broad application in veterinary practice. Especially often medicine is used for cats as pets get to clinics in connection with spasms of smooth muscles of intestines. An etiological factor are hygienic procedures cat's, in the course of "washing", as a rule, there is a swallowing some amount of wool. The papaverine facilitates an otkhozhdeniye of contents of a digestive tube.

Analogs

Coincidence on the ATH code of the 4th level:

Analogs of the Papaverine are various pharmaceutical forms of medicine in which it meets on pharmaceutical shelves. As a rule, the patient does not suit one of forms and then it is necessary to pick up another. It is also possible to replace these products, however previously it is necessary to consult with the qualified specialist in this area, the basic principle of medicine "do not do much harm" it can be easily broken by means of ignorance.

The similar spasmolytic effect renders pharmaceutical drug with the international not patent name of Drotaverinum the Hydrochloride which is known to wide audience under the name of Nospanum. It can also be used both for pregnant women, and for patients of a proctologic or urological hospital, and for children in pediatricheky practice, and for treatment of headaches in house conditions.

Zdravzona

  • Papaverine a hydrochloride of 2% solution for injections of 2 ml No. 10 of an ampulymoskhimfarmpreparata to them N. A. Semashko of joint stock company
  • Papaverine of / hl 40 mg No. 10 tabletkifarmstandart-Tomskhimfarm joint stock company
  • Papaverine of / hl 20 mg No. 10 svechibiosintez joint stock company
  • Platyphyllinum of g/t of 5 mg + papaverine of / x 20 mg No. 10 tabletkivifitekh closed joint stock company
  • Papaverine of / hl MS of 40 mg No. 10 tabletkimedisorb closed joint stock company

Drugstore of IFC

  • Papaverine of / hl candles of 20 mg No. 10, Nizhpharm (N. Novgorod) Russia
  • Papaverine of / hl tbl 40 mg No. 20, Pharmstandard-Leksredstva of joint stock company (Kursk) Russia
  • Papaverine of / hl solution for in 2% 2 ml No. 10, the Armavir biofactory of Fguprossiya
  • Papaverine of / hl tbl 40 mg No. 10, Irbitsky HFZ (Irbit) Russia
  • Papaverine of / hl tbl 40 mg No. 20, Medisorb of closed joint stock company (Perm) Russia
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Apteka24

  • Papaverindarnitsa (Ukraine, Kiev)
  • Papaverinzdorovye (Ukraine, Kharkiv)
  • Papaverinzdorovye (Ukraine, Kharkiv)
  • Papaverin10
  • Papaverinnizhfarm (Russia, Nizhny Novgorod)

Paniapteka

  • Papaverine of / x solution for infection. 2% of amp. 2 ml No. 10OZ GNTsLS
  • Papaverine of / x solution for infection. 2% of amp. 2 ml No. 10OZ GNTsLS
  • Papaverine of / x solution for infection. 2% of amp. 2 ml No. 10OZ GNTsLS
  • Papaverine of / x solution for infection. 2% of amp. 2 ml No. 10OZ GNTsLS

BIOSPHERE

  • Papaverine hydrochloride of 40 mg No. 10 of table.
  • Papaverine a hydrochloride of 2%/2 ml No. 10 solution for in.amp.
  • Papaverine hydrochloride of 20 mg No. 10 supp.rekt.
  • Papaverine of 40 mg No. 10 of table.
  • Papaverine a hydrochloride of 2%/2 ml No. 10 solution for in.amp.
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Section: Gastrointestinal
in more detail

Education: Kharkiv national medical university

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use the Papaverine surely consult with the attending physician.