And whether you know...
Paroksetin of a hydrochloride hemihydrate, calcium hydrophosphate, is glikolit sodium starch (type A), microcrystallic cellulose, magnesium stearate, Opadry II.
Tablets of 20 mg in a cover of a round form of white color in the blister in a cardboard pack No. 20, 30, 60.
Pharmacodynamics and pharmacokinetics
Paroksetin treats group of drugs — strong selection inhibitors of absorption 5-HT that causes its antidepressive action. However, on chemical structure, drug is not inhibitor of the return serotonin reuptake. The antidepressive effect of drug is shown in 8-12 days of its system reception — expressiveness of a condition of a depression, alarm and frustration of a night dream decreases.
Drug is well absorbed in a gastrointestinal tract, reception of antiacid means and food does not influence absorption. Bioavailability varies within 50–100%. Linkng with blood proteins about 95%. Therapeutic concentration of drug in blood after intake is reached in 5 — 8 hours. Stable levels in blood from the beginning of administration of drug are reached in 2 weeks. It is metabolized in a liver at primary passing through it. It is removed with urine and a stake.
Indications to use
- In therapy of a depression of any type (reactive, heavy), and also depressions which is followed by feeling of alarm;
- Treatment and prevention of panic frustration and their recurrence;
- Treatment and prevention of generalized alarming frustration and their recurrence;
- Treatment of a posttraumatic stressful state;
- Treatment of social and alarming states and phobias.
High sensitivity to drug, age till 18 flyings, the period of pregnancy and a lactation. To appoint with care to patients with tendency to attacks, 65 years, with pechenochno / a renal failure are more senior, at reception by the patient of HP — MAO inhibitors.
Allergic reactions, irritability, sleeplessness, tremor, amnesia, dizziness, hyperexcitability of TsNS, disturbance of concentration of attention, emotional lability, delirium, sonitus, eye pain, conjunctivitis, decrease in visual acuity, increase of the ABP, tachycardia, faint, HSN, disturbance of a heart rhythm, rhinitis, cough, loss of appetite, nausea, gastritis, dysphagy, arthritis, miositis, polyuria, cystitis, urination delay, dysmenorrhea, sexual frustration, oliguria, nephrite, itch, furunculosis, small tortoiseshell, eczema, strengthening of a potovydeleniye, knotty erythema, dermatitis, peripheral hypostases.
Paraxinum, application instruction (Way and dosage)
To take a pill Paroksin during food of 1 times a day, it is desirable in the morning.
At conditions of a depression: daily 20 mg. In the absence of therapeutic effect the dosage is raised to improvement of a condition of the patient on 10 mg a day to 50 mg a day. Duration of administration of drug at acute episodes of a depression can proceed within several months.
At conditions of panic frustration the dose of drug makes 40 mg a day, beginning treatment with a dose of 10 mg a day with the subsequent weekly increase in 10 mg up to the maximum dosage — 60 mg a day.
The drugs suppressing activity of enzymes of a liver increase Paroksin's concentration in blood. Joint reception of Paroksin with the HP inducing enzymes of a liver reduce his activity.
At Paroksin's appointment together with Warfarin the risk of emergence of bleeding increases. Paroksin it is necessary to appoint care with anticoagulants.
Paroksin together with the drugs containing tryptophane is not recommended to appoint. At treatment by Paroksin contraindicated alcohol intake.
Terms of sale
At a temperature up to 25 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
About drug among those who accepted Paroksin, in most cases good though also negative meet.
- "… After my child nearly died at walk on the street at me in the eyes, I began panic attacks at each his exit to the street. Reached madness, was afraid only. Appointed treatment Paroksiny, accepted 2 months, now released and the doctor began to reduce a drug dose".
- "… After dismissal from work and unsuccessful search of a new workplace I was depressed — absolute indifference to the future, tearfulness, unwillingness to live. Took various medicine in a complex including Paroksin. Now life began to be adjusted, there was an interest in world around and desire to work".
Some patients note its good efficiency, but point to emergence of dependence on drug.
Section: For a nervous system
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Paroksin surely consult with the attending physician.