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1 tablet contains 0,2 g of active component mifepristone, and also additional components: calcium stearate, starch, microcrystallic cellulose, sugar milk, aerosil.
Drug is issued in the tableted form.
Steroid antigestagenny drug.
Pharmacodynamics and pharmacokinetics
The active, operating component – mifepristone. Effect of medicine Penkrofton is directed to progesterone blocking, action level – gestagenovy receptors. Mifepristone does not possess gestagenny activity. At simultaneous receipt of glucocorticosteroids the antagonism is noted.
Medicine increases sensitivity of a myometrium to effect of prostaglandins, stimulates release of Interlaken in horiodetsidualny cells, increases sokratitelny activity of a myometrium.
Penkrofton allows to remove fetal egg after desquamation of a decidua.
Indications to use
Penkrofton appoint for abortion on early terms (conditionally about 42 days of an amenorrhea at a uterine pregnancy). Drug is used during preparation and induction of childbirth at the full-term pregnancy.
Penkrofton do not appoint at intolerance of mifepristone, long therapy glucocorticosteroids, adrenal insufficiency, a porphyria, anemia, a hem on a uterus, a hysteromyoma, insufficiency of renal and hepatic systems, disturbance of a hemostasis, heavy extragenital pathology, inflammatory diseases of generative organs of the woman.
Mifepristone is not appointed to women 35 years with nicotine addiction are more senior. At suspicion to an extrauterine pregnancy drug is not appointed.
Preparation, induction of childbirth: Penkrofton is contraindicated at an eclampsia, a preekslampsiya, a severe form of a gestosis, postmature pregnancy.
Penkrofton can cause a uterus subinfolyution, a lokhimetra, metrorrhagias, pains and discomfortable feelings in epigastriums, a fever, a hyperthermia, dizzinesses, diarrhea, vomiting, nausea, headaches, weakness, an exacerbation of infections of urinogenital system.
At a combination therapy with mizoprostoly causes dispepsichesky frustration, a vaginitis, bleach, unconscious conditions, anemia, concern, onychalgias, an adynamy, sleeplessness, decrease in hemoglobin.
Penkrofton, application instruction (Way and dosage)
Medicine is appointed only in hospitals and the equipped establishments.
For the purpose of medicamentous abortion appoint a single dose of 600 mg of drug in the presence of the doctor. 400 mg of a mizopristol are in addition applied to strengthening of effect. The woman is observed within two hours (at least) after administration of drug Penkrofton. In 36-48 hours carry out ultrasonography control. 8-14 weeks later determine the level of beta HG and repeat ultrasonography for confirmation of removal of fetal egg from an organism.
In case of inefficiency of the carried-out therapy for the 14th day carry out vacuum aspiration with an obligatory intake of aspirate for histologic research.
Preparation, induction of childbirth: in the presence of the doctor the woman accepts 200 mg of medicine. Reception is repeated in 24 hours in the same dosage.
48-72 hours later estimate a condition of patrimonial ways, resolve an issue of additional purpose of oxytocin and prostaglandins.
Causes adrenal insufficiency.
The concomitant use of drugs of NPVS group is inadmissible.
Terms of sale
It is impossible to buy drug on free sale. It is delivered only medical institutions.
In the place, dry, dark, unavailable to children, at a temperature of 25 degrees Celsius.
Period of validity
No more than two years.
The doctor is obliged to warn the woman that in case of inefficiency of the carried-out therapy Penkrofton it will be necessary to interrupt with drug pregnancy in the operational way (the risk of development of inborn defects in a fruit increases).
Feeding by a breast needs to be stopped for the 14th day after drug use.
Medicine is appointed only in the conditions of a hospital.
To patients with an infectious endocarditis and with the artificial valve of heart in parallel carry out treatment by antibiotics.
Coincidence on the ATH code of the 4th level:
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