Пепфиз Drug photo

The description is actual on 29.07.2016

  • Latin name: Pepfiz
  • ATH code: A09AA
  • Active ingredient: Amylase + Papain + Simetikon (Amilase + Papaine + Simeticone)
  • Producer: Ranbaxy (India)


In 1 tablet of papain of 60 mg, simetikona of 25 mg and fungal diastase of 20 mg. Natrii hydrocarbonas, citric acid, potassium hydrocarbonate, fumaric acid, saccharin, sodium carbonate, sodium lauryl sulfate, fragrance, dye as excipients.

Release form

Soluble tablets.

Pharmacological action

Carminative, normalizing the gastrointestinal tract function.

Pharmacodynamics and pharmacokinetics


The combined drug normalizing processes of digestion at the expense of the contained enzymes. Reduces gas generation and accelerates motility of a gastrointestinal tract. Papain and a fungal diastase – vegetable digestive enzymes. Papain — proteolytic enzyme which is received from lacteal juice of fruits of a papaya. It hydrolyzes proteins, and a fungal diastase — carbohydrates therefore their digestion and assimilation is facilitated. Simetikon influences surface intention of vials of gas, reduces it and bubbles break up. Gases to be absorbed by intestines, and also are removed thanks to the peristaltic movements of intestines.

At dissolution of a sparkling tablet the sodium citrates and potassium neutralizing hydrochloric acid are released. In this regard heartburn and the discomfort connected with a hyperoxemia decreases. Antiacid effect of drug protects digestive enzymes from aggressive action of a gastric juice.


Active agents are chemically inert, are not soaked up and removed through a gastrointestinal tract not changed.

Indications to use

  • overeating and errors in food;
  • chronic pancreatitis with not expressed dysfunction;
  • liver diseases;
  • enteritis;
  • not ulcer dyspepsia;
  • meteorism;
  • the dyspepsia connected with an overeating;
  • the strengthened formation of gases after operations;
  • preparation for ultrasonography and X-ray inspection.


  • age till 12 flyings;
  • hypersensitivity;
  • pregnancy;
  • feeding by a breast.

With care it is applied at arterial hypertension in a type of content of sodium.

Side effects

Allergic reactions.

Pepfiz, application instruction (Way and dosage)

Pill is taken inside, after food. Before the use they are dissolved in 120 ml of water and accepted on 1 tablet three times day. Duration of treatment is defined by the doctor depending on portability and indications. On the eve of researches of abdominal organs (radiological or ultrasonography) within 2 days accept 2 tablets in the morning and in the evening.


Cases of overdose are not known.


It is not recommended to apply together with antacids.

Terms of sale

It is released without recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

2 years.

Pepfiz's analogs

Drugs of a plant origin: Solizim, Nigedaza, Somilaza, Vobenzim, Merkenzim, and also Abomin, Biozim, Normoenzim.

About Pepfiz

Pepfiz is a kind of defoaming agents, but its efficiency is increased by enzymatic components. Tablets Pepfiz possess natural acid resistance therefore are used in a liquid form (the tablet is dissolved in water), it improves hashing with food and it is convenient at treatment of children. Drug eliminates the symptoms connected with gas generation, a hyperoxemia and insufficient digestion of carbohydrates and proteins.

Judging by responses, drug was used at various functional disturbances of digestion for elimination: nausea, an eructation, feelings of weight and discomfort in a stomach, a meteorism and diarrhea. Many patients note noticeable improvement of a state at reception of this drug. The phenomena of gas generation decreased quickly even if the diet was not kept. Reduction of swelling was noted for the third day, and in two weeks — permanent stopping of this symptom. Drug can be used as means of the emergency help. Side effects were not observed.

  • "… High-speed drug — at me well eliminates swelling and an abdominal murmur, feeling of overflow of a stomach".
  • "… Helped me — appetite was normalized and disappeared weight in a stomach and nausea".
  • "… Pepfiz accepted — got rid of abdominal murmurs and weight in a stomach. The chair was normalized".
  • "… Pleasant medicine, for me it was effective at long reception — pains after food and an eructation disappeared".
  • "… The meteorism, disturbs especially in the mornings. Pepfiz, Espumizan, Bifidumbakteriin accepted. Does not help. Probably it is necessary to be inspected seriously at the gastroenterologist".

Many patients did not like taste of drug.

  • "… It was in my opinion possible to do also without dyes with fragrances, this medicine".
  • "… It was not pleasant to me. Taste is too sweet therefore could not take more than one medicine. Why to add to drug sweeteners and dyes".

However, it should be noted that this drug is less effective and is not suitable for replacement therapy of heavy pancreatitis with disturbance of fermental function as activity of enzymes in drug low — is 75 times less, than at drugs of animal origin. As we see, selection of fermental drug is individual and difficult as it is necessary to consider features of disturbances of digestion at each patient.

Section: Gastrointestinal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Pepfiz surely consult with the attending physician.