Pilobakt AM

Пилобакт АМ Drug photo

The description is actual on 01.09.2014

  • Latin name: Pylobact AM
  • ATH code: A02BD05
  • Active ingredient: Amoxicillin (Amoxicillin), Omeprazol (Omeprazole), Klaritromitsin (Clarithromycin)
  • Producer: Ranbaks (India)

Structure

Active agent of Omeprazol is omeprazol. Besides, medicine contains the following additional components: granules from sucrose and corn starch, povidone, sodium lauryl sulfate, lactose, Mannitolum, talc purified sodium hydrophosphate.

The cover of a capsule consists of the following components: diamond blue, gelatin, propilpargidroksibenzoat, karmoizin, methylparahydroxybenzoate. Diethyl phthalate, gipromeloza phthalate, isopropanol, the titan dioxide, dichloromethane are a part of a kishechnorastvorimy cover.

Klaritromitsin's tablets contain in quality of active agent Klaritromitsin, and, besides, the following additional components: silicon dioxide colloid, stearic acid, croscarmellose sodium, the talc purified magnesium stearate, MKTs, povidone.

The film covering consists of a gipromelloza, propylene glycol, titanium dioxide, vanillin, a hypro rod, sorbitan of monooleate, dye quinolinic yellow, the talc purified.

Capsules of Amoxicillin have such active component as Amoxicillin trihydrate. Besides, they included the following additional substances: cellulose microcrystallic, kroskarmelloza, magnesium stearate, silicon dioxide colloid, sodium lauryl sulfate.

The body of a capsule includes dye quinolinic yellow, titanium dioxide, dye a sunset yellow, propilparagidroksibenzoat, gelatin, methylparahydroxybenzoate, sodium lauryl sulfate. And the lid has such components as dye quinolinic yellow, methylparahydroxybenzoate, dye diamond blue, propilparagidroksibenzoat, sodium lauryl sulfate, dye an azoruby, titanium dioxide, gelatin.

Release form

Omeprazol and Amoxicillin contains a set of Pilobakt of AM in capsules, and also Klaritromitsin in tablets.

Pharmacological action

Medicine belongs to antiulcerous means.

Pharmacodynamics and pharmacokinetics

One of components of this medicine – Omeprazol – is the drug oppressing secretion of gastric acid by means of inhibition of enzyme which contains in membranes of covering cells mucous a stomach. It also reduces basal and stimulated secretion. After reception of capsules once the effect comes within an hour and proceeds for all day. Secretory activity after Omeprazol's use is recovered 3-5 days later.

Klaritromitsin is the antibiotic belonging to group of macroleads. This semi-synthetic derivative erythromycin A. He acts as antimicrobic means, suppressing synthesis of protein of microbic cells. At hit in an organism the metabolite 14-gidroksiklaritromitsin which is also effective against many microbes is formed.

Amoxicillin is a semi-synthetic Penicillin which works as a microbicide of a wide range. It inhibits synthesis of a peptidoglikan during division and growth.

All components of a complex of Pilobakt of AM have good absorption at oral administration.

Omeprazol is soaked up through very short time. It is removed mainly with urine. Its bioavailability – about 35% are not dependent on time of meals. The maximum concentration of medicine in plasma – 30-60 minutes later after use. Communication with proteins of plasma – 90%. Omeprazol is almost completely split in a liver.

Klaritromitsin is well and for a short time soaked up from a gastrointestinal tract. At the use of tablets on a hungry stomach the maximum concentration in serum is reached within 2 hours. Meal slows down formation of metabolites a little. Absolute bioavailability of medicine – about 50%. An elimination half-life – 3-4 hours. Drug is widely distributed at hit in an organism. Its concentration in fabrics is higher, than in serum. Communication with proteins – to 70%. Klaritromitsin is brought with kidneys and fecal masses in an invariable view and with metabolites. As a part of a complex of Pilobakt of AM average value of its maximum concentration increases by 10%, and the minimum concentration – for 15% in comparison with monotherapy.

Amoxicillin is in a short space of time soaked up from a gastrointestinal tract. Its bioavailability – about 80%. Time of meal does not exert impact on effect of this drug. Means is in a short space of time distributed in fabrics. Semi-removal time – 60-90 minutes. Communication with proteins of plasma – 20%. About 60% of drug with urine in an invariable look, other quantity – with a stake are removed.

Indications to use

Complex of Pilobakt of AM appoint at eradikatsionny therapy of Helicobacter pylori to the people suffering from a peptic ulcer of a duodenum.

Contraindications

Drug cannot be accepted at:

  • hypersensitivity to its components and antibiotics of group of macroleads;
  • pregnancies;
  • porphyrias;
  • renal and liver failure;
  • children's age;
  • lactations.

Side effects

At use of this means the following side reactions are possible:

The multiformny exudative erythema, skin rash, pseudomembranous coloenteritis, alopecia, photosensitization are in rare instances possible.

Application instruction (Way and dosage)

The drugs entering a complex of Pilobakt of AM are accepted orally.

Each strip is expected days of reception and includes two sets for morning and evening (red and blue).

In the morning accept Omeprazol's capsule, 2 capsules of Amoxicillin and 1 tablet of Klaritromitsin. In evening reception the same dosages.

Capsules and tablet cannot be chewed and broken, they need to be swallowed completely. The course of treatment is expected a week.

Overdose

Overdose by drug is not described.

Interaction

Omeprazol in combination with Phenytoinum, Warfarin and Diazepam can slow down their elimination. It also influences Ketokonazol's absorption, salts of iron and Ampicillin.

In combination with Klaritromitsin concentration of Theophylline, Carbamazepine, Phenytoinum, Lovastatina, a tsizaprida, Astemizola, Cyclosporine, Disopyramidum, Valproatums, Pimozidum and Digoxin therefore strict control of dosages is necessary increases. And at reception together with Terfenadin perhaps not only increase in its concentration, but also lengthening of an interval of QT.

In case of existence of heart diseases in the anamnesis it is not desirable to combine Klaritromitsin with Terfenadin, Astemizol and Tsizaprid. Reception with peroral anticoagulants can lead to potentiation of their effect. Joint appointment with indirect anticoagulants shall be followed by control of protrombinovanny time.

Amoxicillin together with oral contraceptives can reduce their efficiency.

Terms of sale

Means is on sale in drugstores only according to the recipe of the specialist.

Storage conditions

Pilobakt AM needs to be kept dry with a temperature not above 25 °C.

Period of validity

It is necessary to store drug not longer than two years.

About Pilobakt of AM

As a rule, About Pilobakt of AM meet, generally positive. Many patients praise fast action of this medicinal complex. It perfectly helps at ulcers and at the same time very seldom gives any side effects.

The price of Pilobakt of AM where to buy

The price of Pilobakt of AM is slightly higher than 1000 rubles. In some drugstores cost can be less.

Zdravzona

  • Pilobakt am komb.nabor No. 56 of table and kaps
  • Pilobakt AM the combined set a set 8х7 tablets and kapsulyranbaxy

Drugstore of IFC

  • Pilobakt AM the combined set tbl and kaps No. 7, Ranbaxyindiya
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Section: Antibiotics Antimicrobic
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