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In 1 capsule of pipemidovy acid of 200 mg. Lactoses monohydrate, sodium krakhmalglikolit, silicon dioxide, magnesium stearate as excipients.
Capsules on 200 mg.
Pharmacodynamics and pharmacokinetics
Treats hinolonovy drugs, has bactericidal effect. Active agent inhibits DNA replication of bacteria, contacting the DNK-girazoy enzyme participating in process of reduplication of DNA. Action on the microorganisms which are in a proliferation phase is more expressed. Synthesis of bacterial proteins is inhibited by high concentration of active ingredient. Shows activity concerning Proteus vulgaris, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Neisseria. Gram-positive microorganisms are insensitive to pipemidovy acid.
At intake it is well soaked up, bioavailability of 30-60%. The maximum concentration at reception of 400 mg is defined in 70 minutes. The highest concentration are defined in kidneys. Gets through a placenta.
Pipemidovy acid in an invariable look is emitted from an organism mainly with kidneys. In daily urine about 80% of a dose of drug are found. Time of a poluvyveleniye makes 2 hours. At a renal failure higher concentration in blood are defined and the elimination half-life is extended — 6-16 hours.
Indications to use
- abnormal liver function and kidneys;
- children's age;
- existence of an oliguria and anury;
- lactation period;
- defeats of TsNS.
- Nausea, liquid chair;
- dizziness, headache;
- depressive frustration;
- vision disorder;
- psychoses (very seldom);
- muscular weakness and mialgiya;
- convulsive attacks (very seldom);
- allergic rash;
- itch and urticaria.
With care it is applied at persons with deficit of glucose-6-dihydrogenase as there is a risk of hemolitic anemia, and also at persons 70 years, at patients with a hematencephalon in the anamnesis and epilepsy are more senior.
Pimidel, application instruction (Way and dosage)
Drug is accepted inside, on 2 capsules by 2 times a day before food. In the presence of steady microorganisms the dose increases twice. Treatment duration at cystitis of 10 days, according to the recommendation of the doctor longer reception is possible. At pyelonephritises a course of treatment of 3-6 weeks, and at prostatitis till 8 weeks. Plentiful drink is recommended.
At emergence of allergic reactions stop its reception. At prolonged use it is desirable to check function of a liver and kidneys.
Overdose is shown by nausea, vomiting, confusion of consciousness, a headache, a tremor. In more hard cases emergence of spasms is possible. The gastric lavage and control of function of blood circulation and breath is recommended.
There is no specific antidote. Removal can be accelerated an artificial diuresis. Drug is well removed by a hemodialysis.
Active ingredient of drug inhibits P450 enzyme therefore significant reactions of interaction are observed at reception with caffeine and theophylline which concentration in blood considerably increase. Delay of their metabolism is shown by undesirable reactions.
Terms of sale
According to the recipe.
Temperature is up to 25 °C.
Period of validity
Palinum, Pilamin, Pipegal, Urotraktin, Vero-Pipemidin, Uropimid, Pipem, Pipelin.
The first generation of not fluorinated hinolon includes drugs of nalidixic, oxolinic and pipemidovy acid which also Pimidel treats. Drugs of pipemidovy acid are the most active for treatment of diseases of urinary tract. This drug is uroseptiky — well gets into fabrics of urinogenital system, and in urine creates sufficient concentration for therapeutic effect. Possesses a wide range of activity (the majority of gram-negative microorganisms and staphylococcus), 2 times a day are accepted that is acceptable for patients.
The majority of positive responses is connected with reception of this drug at cystitis. At this disease it is appointed a short course (3-7 days).
- "… There was acute cystitis, severe pains. Pimidel very much helped me".
- "… Helps me, after one reception in 2 hours it becomes better".
- "… Accepted at cystitis — helps quickly, already 3 hours later it becomes easier, pains and discomfort in the bottom of a stomach leave".
Besides at cystitis reception of vegetable uroantiseptik and plentiful drink is necessary. When the effect of treatment is not observed by this drug, it is necessary to make bacteriological crops of urine and determination of sensitivity to antibiotics.
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