Plagril

Плагрил Drug photo

The description is actual on 13.03.2015

  • Latin name: Plagril
  • ATH code: B01AC04
  • Active ingredient: Klopidogrela hydrosulphate (Clopidogrel hydrosulfate)
  • Producer: Dr. Reddy´s Laboratories Ltd. (India)

Structure

In one tablet, film coated there are 97,875 mg of active connection — a klopidogrel of hydrosulphate that 75 mg of a klopidogrel are equivalent.

As auxiliary inactive substances are used: MKTs, Mannitolum, croscarmellose sodium, colloid silicon dioxide and magnesium stearate.

Film cover — 13,475 mg of Opadry 03B54202 of pink color which for 62,5% consists of a gipromelloza, on 30,6%-from titanium dioxide, 6,25% — a macrogoal of 400 and 0,65% of dye ferrous oxide red.

Release form

Plagril is issued in tablets of a round biconvex form. They are covered with a pink film cover, have a stamping "With 127" on one of the parties.

Drug is issued in blisters on 10 table. In 1 cardboard pack there can be 3 or 10 blisters.

Pharmacological action

Anti-aggregation, koronarodilatiruyushchy.

Pharmacodynamics and pharmacokinetics

Active ingredient of Plagril — klopidogret hydrosulphate is specific inhibitor of aggregation of thrombocytes. Thanks to selective decrease in linkng of ADF with the receptors located on thrombocytes and activation of receptors of GPIIb and IIIa weakens actually aggregation of thrombocytes.

Drug is characterized by high absorption and bioavailability. Concentration in plasma in 2 hours does not reach a standard limit of measurement — 0,025 mkg/l. The metabolism occurs in a liver. Metabolite half-life – inactive derivative carboxyl acid after repeated doses in 1 hour reaches the maximum concentration in 3 mg on 1 l. Removal happens kidneys approximately for 50%, through intestines it is slightly less — 46%, at the period after one-time and repeated use — 8 h.

Indications to use

Drug is appointed most often as a prophylactic of such states and diseases:

  • trombotichesky complications after the myocardial infarction (MI), an ischemic stroke, occlusion of peripheral arteries;
  • trombotichesky complications at an acute form of the coronary syndrome which is followed on an ECG by raising of ST and admissibility of thrombolytic therapy at unstable stenocardia, a heart attack without Q tooth, including after stenting.

Contraindications

  • individual intolerance of components of drug;
  • severe forms of a liver failure;
  • the hemorrhagic syndrome, acute bleedings, intracraneal hemorrhages, diseases leading to their development, for example a peptic ulcer of a stomach and a 12-perstny gut during the aggravation periods, tuberculosis, a tumor of lungs;
  • pregnancy and period of feeding by a breast;
  • age group — till 18 flyings.

With care it is recommended to apply if:

  • the liver or renal failure is diagnosed;
  • injuries or state with the increased risk of bleedings, the postoperative period were postponed;
  • at simultaneous use with inhibitors of cyclooxygenase-2, glycoprotein receptors (an integrin of IIb-IIIA), and also with heparin.

Side effects

From various bodies and systems of a human body there can be following side reactions:

  • System of a hemopoiesis: infrequent cases of thrombocytopenia, besides development of a neutropenia, leukopenia, an eosinophilia is possible, it is more rare — a Werlhof's disease, a granulocytopenia, an agranulocytosis, anemia.
  • Blood coagulations: gastrointestinal, nasal bleedings, lengthening of their time, a hemorrhagic stroke, are more rare cases of a hamaturia, conjunctival hemorrhages, hematomas.
  • Nervous system: infrequently headaches, dizziness and paresthesia were registered, cases — vertigo, confusion of consciousness and a gallyutsinirovaniye are rare.
  • Cardiovascular: vasculitis, lowering of arterial pressure.
  • Respiratory system: bronchospasm, intersticial pneumonia.
  • Alimentary system: more than 1% of the studied patients had an indigestion, diarrhea and abdominal pains. In a smaller measure such side effects as nausea, development of gastritis, a meteorism, emergence of locks or vomiting, an ulceration mucous by a gastrointestinal tract, an exacerbation of stomach ulcer and 12 perstny guts were observed, and also cases of colitis ulcer or lymphocytic, pancreatitis, changes of flavoring feelings, an acute hepatic unsufficiency or increase of activity of its enzymes, such inflammations as stomatitis, hepatitis are rare.
  • Musculoskeletal system: arthralgia, arthritis or mialgiya.
  • Urinary system: glomerulonephritis.
  • Integuments: an itch, violent or erythematic rash, an erythema, a toxic necrolysis, eczema, flat deprive, Stephens-Johnson's syndrome.
  • Immune system: Quincke's disease, anaphylactoid reactions, small tortoiseshell, serum disease.
  • Among other side reactions perhaps: temperature increase, increase in concentration of creatinine in a circulatory bed.

Application instruction of Plagril (Way and dosage)

It is necessary to take a pill orally inside, regardless of receptions of food.

For prevention of ischemic disturbances, not later, than in 35 days after a myocardial infarction and 1-25 weeks after the had ischemic stroke: adult and elderly appoint a dose of 75 mg a day for 1 reception.

At an acute coronary syndrome without ST raising on an ECG: treatment assumes reception of a single load dose in 300 mg, and the subsequent administration of drug — 75 mg a day for 1 time. The application instruction of Plagril in this case assumes a combination to acetylsalicylic acid in a dose of 75-325 mg a day. The optimum course of treatment has to last till 1 year.

At an acute coronary syndrome with ST raising on an ECG: it is necessary to accept drug on 75 mg (1 tab.) in days, since the load dose combined with acetylsalicylic acid or without trombolitik. To patients 75 years are more senior it is possible to carry out treatment by Klopidogrel without load dose. The similar combination therapy has to last at least 4 weeks.

Overdose

Oral administration of 600 mg of a klopidogrel (8 tab.) for time at investigated did not show any by-effects. The bleeding time was extended by 1,7 times, as well as at reception of a therapeutic dose in 75 mg/days.

As treatment effective is a transfusion of a platelet concentrate. A specific antidote it was not open for today.

Interaction

Plagril can cause various reactions at simultaneous use with the following HP:

  • With acetylsalicylic acid, heparin, indirect anticoagulants and NPVS: there is a strengthening of antiagregantny effects, and also increase of risk of development of bleedings of a gastrointestinal tract.
  • With the drugs which are metabolized with the participation of CYP2C9 (for example, Phenytoinum, Tolbutamidum): Plagril, inhibiting activity of CYP2C9, causes increase in concentration of HP.

Terms of sale

It is released in drugstores according to the recipe.

Storage conditions

In the dry dark place, temperature no more than 25 ° Celsius.

In the unavailable place for children.

Period of validity

Use after 2 flyings from the date of production is forbidden.

Special instructions

If at surgical intervention antiagregantny action of Plagril is undesirable, then it is necessary to stop reception of tablets in 7 days prior to the planned operative measure.

Attention! At Plagril's reception it is necessary to notify the attending physician at each unusual bleeding as it can demand bigger time for a stop. And also it is necessary to inform on therapy during the planning of surgeries or purpose of new medicine.

Plagril's analogs

Among analogs such medicines are known:

Zdravzona

  • Plagril of 75 mg No. 30 of a tablet

Drugstore of IFC

  • Plagril tbl p/pl/o 75 mg No. 30, Dr. Reddy's Labindiya
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Apteka24

  • Plagrildr. Reddy's (India)

Paniapteka

  • Plagril of the tab. p / about 75 mg No. 30

BIOSPHERE

  • Plagril of 75 mg No. 10 tabl.p.p.o.
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Section: For blood
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Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Plagril surely consult with the attending physician.