Prednisolonum

Преднизолон Drug photo

The description is actual on 15.09.2015

  • Latin name: Prednisolone
  • ATH code: D07AA03
  • Active ingredient: Prednisolonum (Prednisolone)
  • Producer: CJSC NPTs Elfa, JSC Biosintez (Russia), JSC Borisovsky Plant of Medical Supplies (Republic of Belarus), M. J. Biofarm Pvt. Ltd. (India), Warsaw Pharmaceutical Works Polfa (Poland), Gedeon Richter Plc. (Hungary)

Structure

Composition of Prednisolonum in ampoules: active substance in concentration of 30 mg/ml, and also sodium pyrosulphite (E223 additive), dinatrium edetat, nikotinamid, sodium hydroxide, water for and.

Composition of Prednisolonum in tablets: 1 or 5 mg of active substance, colloid silicon dioxide, magnesium stearate, stearic acid, starch (potato and corn), talc, lactoses monohydrate.

Prednisolonum ointment contains 0,05 g of active substance, soft white paraffin, glycerin, stearic acid, methyl - and propilparagidroksibenzoat, Cremophor A25 and A6, the purified water.

Release form

  • Solution for in/in and introductions of 30 mg/ml 1 ml in oil; 15 mg/ml 2 ml.
  • Mg tablets 1 and 5.
  • Ointment for outside therapy of 0,5% (the ATH code — D07AA03).
  • Drops eye 0,5% (the ATH code — S01BA04).

Pharmacological action

Pharmacological group: Corticosteroids (group of drug — I, it means that Prednisolonum is GKS of weak activity).

Prednisolonum — hormonal or not?

Prednisolonum is a hormonal drug for topical and system administration of average duration of action.

Represents the dehydrogenated analog of the hydrocortisone hormone developed by bark of adrenal glands. Activity is four times higher than it activity of a hydrocortisone.

Prevents development of allergic reaction (if reaction already began, stops it), suppresses activity of immune system, removes an inflammation, increases sensitivity β2-адренорецепторов to endogenous catecholamines, has antishock effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics: Prednisolonum — what is it?

The mechanism of effect of Prednisolonum is connected with its ability to interact with certain intracellular (cytoplasmatic) receptors. These receptors are in all body tissues, but most of all them — in a liver.

As a result of this interaction complexes are formed inducing protein synthesis (including enzymes which regulate the vital intracellular processes).

Operates on all stages of development of inflammatory process: suppresses synthesis of Pg at the level of arachidonic acid, and also interferes with formation of pro-inflammatory cytokines — IFN-β and IFN-γ, IL-1, FNO, neopterine; increases resistance of plasma membranes to influence of disturbing factors.

Influences a metabolism of lipids and proteins, and also — in a little smaller degree — an exchange of water and electrolytes.

The immunodepressive effect is implemented due to ability of drug to cause involution of an adenoid tissue, to oppress proliferation of lymphocytes, migration of V-cells, both interaction In - and T lymphocytes, to slow down release of IFN-γ, IL-1 and IL-2 from macrophages and lymphocytes, to reduce antibody formation.

Braking of allergic reaction is carried out due to decrease in secretion and synthesis of mediators of an allergy, reduction of number of the circulating basphilic leukocytes, suppression of release of a histamine from sensitized mast cells and basphilic leukocytes, suppression of development of a connecting and adenoid tissue, reduction of number of mast cells, In - and T lymphocytes, decrease in sensitivity of T-effectors to mediators of an allergy, suppression of antibody formation, change of an immune response.

Inhibits synthesis and secretion of corticotropin and — for the second time — endogenous GKS.

At external use removes an inflammation, slows down development of allergic reaction, removes an itch and an inflammation, reduces exudation, suppresses activity of immune system concerning reactions of hypersensitivity of the III-IV type.

Pharmacokinetics

After reception of a tablet it is quickly and most fully absorbed from a gastrointestinal tract. Tsmakh — from 60 to 90 minutes. About 90% of the accepted Prednisolonum dose contact plasma proteins.

Substance is exposed to biotransformation in a liver. From 80 to 90% of products of a metabolism are removed with urine and bile, about 20% of a dose — eliminirutsya in pure form. T1/2 — from 2 to 4 hours.

Indications to Prednisolonum use

From what tablets and solution for injections?

System use is reasonable at:

  • allergic diseases (including at an allergy food or medicamentous, a toksikodermiya, a serum disease, atopic/contact dermatitis, a pollinosis, allergic rhinitis, the small tortoiseshell, Stephens-Johnson's syndrome, a Quincke's edema);
  • to small chorea, rheumatic fever, rheumatic carditis;
  • acute and chronic diseases which are followed by an inflammation in joints and circumarticular fabric (the synovitis, nonspecific tendosinovit, seronegative spondylarthrites, an epicondylitis, an osteoarthritis (including posttraumatic), etc.);
  • diffusion diseases of connecting fabric;
  • multiple sclerosis;
  • asthmatic status and OH;
  • lung cancer (medicine is appointed in a combination with cytostatics);
  • intersticial diseases of pulmonary fabric (fibrosis, acute alveolitis, sarcoidosis , etc.);
  • eosinophilic and aspiration pneumonia, tubercular meningitis, a pulmonary tuberculosis (as addition to specific therapy);
  • primary and secondary hypocorticoidism (including after an adrenalectomy);
  • inborn adrenal struma (IAS) or dysfunction of their bark;
  • granulematozny thyroiditis;
  • autoimmune diseases;
  • hepatitis;
  • inflammatory diseases of a gastrointestinal tract;
  • hypoglycemic states;
  • nephrotic syndrome;
  • diseases of the hemopoietic bodies and blood (leukoses, anemias and systems of a hemostasis of a disease connected with defeat);
  • wet brain (post-radiation, developing at a tumor, after hirurgicheksky intervention or an injury; in the summary and the reference book Vidal is specified that at wet brain treatment is begun with parenteral forms of drug);
  • autoimmune and other diseases of skin (including an illness of Dyuringa, psoriasiseczema, a pemphigus, a Lyell's disease, exfoliative dermatitis);
  • diseases of eyes (including autoimmune and allergic; including uveites, allergic ulcer keratitis, allergic conjunctivitis, sympathetic ophthalmia, choroiditis, iridocyclitis, not purulent keratitis, etc.);
  • the hypercalcemia developing against oncological diseases.

Indications to use of pricks are medical emergencies, for example, a bad attack of food allergy or an acute anaphylaxis. After several days of parenteral use of the patient, as a rule, transfer to the tableted Prednisolonum form.

The indication to use of tablets are the pathologies having chronic character and proceeding in a severe form (for example, bronchial asthma).

Also solution and the tablets Prednisolonum apply to the prevention of graft rejection and stopping of nausea/vomiting at the patients receiving cytostatics.

Ointment Prednisolonum: for what and when external use of drug is shown?

As outside means Prednisolonum is applied from an allergy and to treatment inflammatory skin diseases of not microbic etiology. Indications to ointment use:

  • limited neurodermatitis;
  • dermatitis (contact, allergic and atopic);
  • diskoidny lupus erythematosus;
  • psoriasis;
  • eczema;
  • erythrosis;
  • toksikodermiya;
  • small tortoiseshell.

Prednisolonum: for what appoint eye drops?

Drops in eyes are appointed for stopping of the inflammations of the noninfectious nature, and also inflammations striking a front segment of an eye which develop after an injury of an eye or ophthalmologic operation.

Topical administration of Prednisolonum is reasonable at the following diseases of eyes:

  • iridocyclitis;
  • uveitis;
  • iritis;
  • allergic conjunctivitis;
  • keratitis (in particular, discal and parenchymatous; in cases when epithelial fabric of a cornea is not damaged);
  • sclerite;
  • episcleritis;
  • blepharitis;
  • blefarokonjyunktivit;
  • sympathetic ophthalmia.

Contraindications

In need of system use of drug according to vital indications the intolerance of one or several components which are their part can only be contraindication.

Other contraindications to use of solution and tablets are:

  • infectious and the parasitic diseases caused by bacteria, fungi or viruses (including recently transferred the person, including contact with the patient). Are among such diseases: a herpesviridae infection, measles, a strongyloidosis (or suspicion on it), an amebiasis, tuberculosis (active or latent), system mycosis.
  • Diseases of bodies of a digestive tract (a peptic ulcer of a 12-tiperstny gut / stomach, a round ulcer, NYaK with threat of abscessing or perforation, recently imposed anastomosis of an intestinal tube, a diverticulitis).
  • Cardiovascular pathologies, including recently postponed myocardial infarction (at patients with acute/subacute to THEM use of Prednisolonum can provoke distribution of the necrotic center and slow down forming of cicatricial fabric that in turn increases risk of a rupture of a cardiac muscle), dekompensirovanny HSN, arterial hypertension.
  • Lipidemia.
  • Immunodeficiency (including HIV infection, AIDS).
  • The postvaccinal period (drug also 2 weeks after introduction of a vaccine do not appoint during the period lasting 8 weeks to).
  • The lymphadenitis which developed after an inoculation of BTsZh.
  • Diseases of endocrine system: an illness of Itsenko-Kushinga, hyper - or a hypothyroidism, a diabetes mellitus.
  • Heavy degree of functional insufficiency of kidneys/liver.
  • Urolithiasis.
  • Hypoalbuminemia, and also states contributing to its development.
  • System osteoporosis.
  • Acute psychosis.
  • gravis myasthenia.
  • III-IV stages of obesity.
  • It is closed - and an open angle glaucoma.
  • Poliomyelitis (an exception — a form of bulbar encephalitis).
  • Lactation.
  • Pregnancy.

To patients with serious infectious diseases of a tablet and pricks of Prednisolonum are appointed only against specific therapy.

Contraindications to intra joint administration of drug are:

  • the pathological bleeding (caused by use of anticoagulants or endogenous);
  • piogenic arthritis and periartikulyarny infections (including in the anamnesis);
  • chressustavny bone fracture;
  • system infections;
  • "Sukhoi" a joint (lack of signs of inflammatory process in a joint: for example, at an osteoarthrosis without signs of an inflammation of a synovial membrane);
  • the expressed deformations of a joint, bone destruction or circumarticular osteoporosis;
  • the instability of a joint which developed against arthritis;
  • aseptic necrosis of an epiphysis of bones which creates a joint;
  • pregnancy.

On skin Prednisolonum should not be applied at:

  • mycoses, viral and bacterial damages of skin;
  • skin displays of syphilis;
  • skin tumors;
  • tuberculosis;
  • acne illness (in particular, at pink and ordinary eels);
  • pregnancies.

Eye drops do not appoint to patients with fungal and virus infections of eyes, the broken integrity of an epithelium of a cornea, at trachoma, acute purulent and viral conjunctivitis, a purulent infection a century and a mucous membrane, a purulent helcoma, tuberculosis of eyes, and also at the states which developed after removal of a foreign subject from an eye cornea.

Side effects of Prednisolonum

The frequency of development and expressiveness of side effects of Prednisolonum are influenced by the used dose, duration, a way, and also a possibility of observance of a circadian rhythm of use of drug.

System use of means can become the reason:

  • delays of liquid and Na + in an organism, developments of nitrogenous deficit, a gipokaliyemichesky alkalosis, a hypopotassemia, a glucosuria, a hyperglycemia, a weight set;
  • secondary hypocorticoidism and hypopituitarism (especially if reception of GKS matches the stress periods — injuries, surgeries, diseases, etc.), suppression of growth at children, a syndrome of Kushinga, disturbances of a menstrual cycle, manifestation of sugar LADA diabetes, decrease in tolerance to glucose, increases of need for peroral hypoglycemic means and insulin at diabetics;
  • increases of the ABP, HSN (or strengthenings of its expressiveness), the hypercoagulations characteristic of a hypopotassemia of ECG changes, thrombosis, distribution of the necrotic center and delay of forming of a hem with a possible rupture of a cardiac muscle at patients with acute/subacute to THEM, an obliterating endarteritis;
  • steroid myopathy, muscular weakness, aseptic necrosis of a head humeral and femur, loss of muscle bulk, compression spinal fracture and pathological fractures of tubular bones, osteoporosis;
  • ulcer esophagitis, meteorism, digestive disturbances, vomiting, nausea, strengthening of appetite, development of a steroid ulcer with possible complications in the form of its perforation and bleedings from ulcer defect, pancreatitis;
  • hypo - or hyperpegmentations of skin, an atrophy of skin and/or hypodermic cellulose, appearance of eels, atrophic strips, abscesses, the slowed-down healing of wounds, ecchymomas, petechias, thinnings of skin, strengthening of sweating, an erythema;
  • mental disturbances (hallucinations, a delirium, euphoria, a depression are possible), a brain pseudoneoplasm syndrome (most often develops at children at too fast dose decline and it is shown in the form of decrease in visual acuity, headaches, a diplopia), sleep disorders, vertigo, dizzinesses, a headache, development of a cataract with localization of opacification in back part of a crystalline lens, eye hypertensia (at the same time there is a probability of damage of an optic nerve), a steroid exophthalmos, glaucoma, a sudden blindness (at administration of solution for and to the area of nasal bosoms, the heads and necks);
  • hypersensitivity reactions (both local, and generalized);
  • general weakness;
  • unconscious states.

Use effects on skin:

  • teleangiectasias;
  • purpura;
  • steroid eels;
  • burning, irritation, dryness and itch of skin.

When drawing on extensive surfaces of an integument and/or at prolonged use of ointment system effects, a hypertrichosis develop, atrophic changes and secondary infection of skin are also possible.

Treatment by drops for eyes can be followed by eye hypertensia, damage of an optic nerve, disturbance by sharpness/narrowing of fields of vision, increase of probability of perforation of a cornea of an eye, development of a cataract with localization of opacification in back part of a crystalline lens. Distribution of a fungus or viral disease of eyes is in rare instances possible.

Withdrawal signs

"Withdrawal" can become one of effects of use of GKS. Its weight depends on a functional condition of bark of adrenal glands. In mild cases after the treatment termination by Prednisolonum the indisposition, weakness, fast fatigue, muscular pains, appetite loss, a hyperthermia, an aggravation of a basic disease are possible.

In hard cases at the patient hypoadrenal crisis which is followed by vomiting, spasms, a collapse can develop. Without introduction of GKS to short terms there occurs the death from acute cardiovascular insufficiency.

Application instruction of Prednisolonum

The application instruction of Prednisolonum in pricks

Solution is entered intravenously, intramusculary and vnutrisustavno.

The way of introduction and dosage of Prednisolonum (Prednisolonum Nikomed, Prednisolonum of a gemisuktsinat) are selected individually attending physician taking into account a type of pathology, weight of a condition of the patient, localization of the struck body.

At serious and life-threatening conditions to the patient appoint pulse therapy using during a short span of ultrahigh doses. Within 3-5 days to it by method of intravenous drop infusion daily enter 1-2 g of Prednisolonum. Duration of procedure is from 30 minutes till 1 o'clock.

During treatment the dosage is adjusted depending on the response of an organism of the patient to therapy.

Optimum it is considered to enter Prednisolonum in / century. For intra joint introduction of an ampoule with Prednisolonum use only when pathological process struck fabrics in a joint.

Positive dynamics is a reason for transfer of the patient into tablets or candles with Prednisolonum. Treatment by tablets is continued before development of permanent remission.

At impossibility of administration of Prednisolonum in/in, medicine should be entered deeply into a muscle. However it is necessary to consider that at such way it is soaked up more slowly.

In a human body emission of hormones of adrenal glands in a blood stream happens during the period between 6 and 8:00 in the morning therefore injections also should be done at this time. All daily dose is entered, as a rule, at once. If it is impossible, in the morning is entered not less ⅔ the appointed dose, remained a third it is necessary to enter during the lunchtime (approximately at 12:00).

Depending on pathology the dose can fluctuate within 30-1200 mg/days (with the subsequent its decrease).

To children aged from two months till 1 year enter from 2 to 3 mg/kg. A dosage to children from a year to 14 flyings — 1-2 mg/kg (in the form of slow, lasting 3 minutes, an intramuscular injection). If necessary in 20-30 minutes medicine is entered repeatedly in the same dose.

At damage of a large joint enter from 25 to 50 mg of Prednisolonum into it. Enter from 10 to 25 mg into joints of average size, in small — from 5 to 10 mg.

Tablets Prednisolonum: application instruction

Transfer to reception of tablets of the patient, following the principle of gradual cancellation of GKS.

In case of use of ZGT sick appoint from 20 to 30 mg of Prednisolonum a day. A maintenance dose — from 5 to 10 mg/days. At some pathologies — for example, at a nephrotic syndrome — it is reasonable to appoint higher doses.

For children the starting dose makes 1-2 mg/kg/days (it is necessary to divide it into 4-6 receptions), supporting — from 0,3 to 0,6 mg/kg/days. At appointment consider a day-night secretory rhythm of endogenous steroid hormones.

Recommendations concerning use of drugs of different producers identical. That is the instruction on tablets Nikomed does not differ from the instruction on the tablets made by the Biosintez company.

Ointment Prednisolonum: application instruction

Ointment is means of outside therapy. It is necessary to apply on affected areas of skin it with a thin layer to from 1 to 3 rubles/days. It is possible to apply an occlusive bandage for strengthening of effect the limited pathological centers.

In case of use for children is more senior than one-year-old age drug should be used shorter course. Also it is necessary to exclude the actions promoting strengthening of absorption and a resorption of Prednisolonum (the occlusal, fixing, warming bandages).

Eye drops: application instruction

Instillations by drug spend 3 rubles/days, digging in 1-2 drops of solution in a conjunctival cavity of the affected eye. In an acute phase of a disease procedure of an instillation is allowed to be repeated every 2-4 hour.

To the patients who underwent an ophthalmologic operation, drops are appointed to 3-5 days after surgical intervention.

How it is long possible to accept Prednisolonum?

Therapy by glucocorticosteroids is directed to achievement of the maximum effect by minimum possible doses.

Duration of treatment depends on the diagnosis of the patient and individual reaction to treatment. In some cases the course lasts till 6 days, at ZGT it lasts for months. Duration of outside therapy using ointment Prednisolonum usually from 6 to 14 days.

Dosage for animals

The dosage for dogs and for cats is selected individually depending on indications.

So, for example at infectious peritonitis the cat should give in 1 ruble/days on 2-4 mg/kg of Prednisolonum, at chronic panleukopenia — 2 rubles/days on 2,5 mg.

Standard dosage to a dog — 1 mg/kg of 2 rubles/days. Treatments 14 days last. Upon completion of a course it is necessary to make tests and to pass survey at the doctor. At drug withdrawal it is necessary to lower a dose for dogs by 25% every 14 days.

Overdose

Overdose is possible at prolonged use of drug, especially, if to the patient high doses are appointed. It is shown by peripheral hypostases, increase of the ABP, strengthening of side effects.

At acute overdose it is necessary to wash out immediately a stomach or to give to the patient emetic. Prednisolonum has no specific antidote. At emergence of symptoms of overdose of chronic character it is necessary to lower the used dose.

Interaction

Interaction with other means is noted only at system use of Prednisolonum.

Rifampicin, antiepileptic means, barbiturates promote acceleration of a metabolism of Prednisolonum and weaken its action. Efficiency of drug decreases also in combination with antihistaminic drugs.

Karboangidraza inhibitors, Amphotericinum In, thiazide diuretics increase probability of development of a heavy hypopotassemia, sodium the containing means — increases of the ABP and hypostases.

In a combination with Paracetamol the risk of development of hepatotoxic effects increases, in a combination with tricyclic antidepressants strengthening of the mental disturbances connected with reception of Prednisolonum (including expressiveness of a depression), in a combination with immunodepressants — increase of risk of development of an infection and limfoproliferativny processes is possible.

In combination with ASK, NPVP and alcohol the probability of development of a peptic ulcer and bleedings from ulcer defects increases.

Peroral contraceptive means change farmakodinamichesky parameters of Prednisolonum, strengthening that its therapeutic and toxic action.

Prednisolonum weakens anticoagulative effect of anticoagulants, and also effect of insulin and peroral hypoglycemic means.

Use of Prednisolonum in immunodepressive doses in combination with live vaccines can provoke replication of viruses, decrease in development of antibodies, development of viral diseases. In case of use with the inactivated vaccines the risk of decrease in development of antibodies and neurologic disturbances increases.

At prolonged use increases the content of folic acid, in a combination with diuretics can provoke disturbances of an electrolytic exchange.

Terms of sale

For acquisition of Prednisolonum it is necessary to have the recipe on drug.

The recipe of Prednisolonum on Latin (for introduction in oil to the child about one year):

Rp: Sol. Prednisoloni hydrochloride of 3% — 1,0

D.t.d. N 3 in amp.

S. 0,7 ml in oil (in oil – 2 mg/kg/days; in/in – 5 mg/kg/days)

Storage conditions

Ointment keeps the properties at a temperature of 5-15 °C, tablets and solution for system use — at a temperature up to 25 °C, drops for eyes — at a temperature of 15-25 °C.

Contents of the opened bottle with drops have to be used within 28 days.

Period of validity

For ointment, tablets and solution for system use — two years, for eye drops — three years.

Special instructions

Treatment by Prednisolonum needs to be stopped slowly, smoothly reducing a dose.

To the patients having psychoses in the anamnesis, it is allowed to appoint high doses only under strict control of the doctor.

How "to get down" from Prednisolonum?

Treatment by Prednisolonum should be completed gradually. The dose decline is carried out, weekly reducing the used dose on ⅛ or accepting the last dose every other day and reducing it at the same time on ⅕ (this way faster).

At a fast way in day without Prednisolonum stimulation of adrenal glands using UVCh DKV silt on their projection, reception of ascorbic acid (500 mg/days), administration of insulin in the accruing doses is shown to the patient (starting — 4 PIECES, further on each reception raise it on 2 PIECES; the highest dose — 16 PIECES).

Insulin should be pricked before a breakfast, within 6 hours after an injection of people has to remain under supervision.

If Prednisolonum is appointed at bronchial asthma, it is recommended to pass to inhalation steroids. If the indication to use is the autoimmune disease — on soft cytostatics.

Features of a diet at Prednisolonum reception

At reception of Prednisolonum it is recommended to exclude from a diet fried and acute products, and also fruit and acid juice which stimulate secretion of hydrochloric acid.

Besides, it is necessary to limit quantity of high-calorific food with the high content of carbohydrates and fats (their consumption against GKS-therapy promotes increase of level of glucose in blood and to a fast set of weight), table salt and liquid.

When cooking it is necessary to use products which contain potassium salts, calcium and protein (dietary grades of meat, dairy products, fruit, firm cheeses, baked potatoes, prunes, apricots, nuts, vegetable marrows and so forth).

What it is possible to replace Prednisolonum with?

Analogs on structure for dosage forms for system use: Prednisolonum Nikomed (in ampoules), Prednisolonum Nikomed in tablets, Prednisolonum Bufus (solution), Medopred (solution), Prednizol (solution).

Similar drugs with the close mechanism of action: Betamethasone, Hydrocortisone, Dexasonum, Deksamed, Dexamethasone, Kenalogum, Lemod, Medrolum, Deltason, Methypredum, Rektodelt, Triamcinolonum, Flosteron.

Analogs of ointment: Prednizolon-Fereyn, Hydrocortisone.

Analogs of eye drops: Hydrocortisone, Deksametazon, Deksapos, Maksideks, Oftan Deksametazon, Deksoftan, Prenatsid, Deksametazonlong, Ozurdeks.

Zdravzona

  • Prednisolonum 5 of mg No. 100 PFK Tablet/renewal/updating of closed joint stock company
  • Prednisolonum 5 of mg No. 30 of a tablet
  • Prednizolon-Nikomed 25mg/ml solution for injections of 1 ml No. 3 ampulynikomed Austria Gmbh
  • Prednisolonum 5 of mg No. 100 tabletkiakrikhin HFK of joint stock company
  • Prednizolonovy ointment of 0,5% 10gnizhfarm joint stock company

Drugstore of IFC

  • Prednisolonum tbl 5 mg No. 100, Gedeon Richter/Gideon-Richter-RUS Zaorossiya
  • Prednisolonum tbl 5 mg No. 100 **, Moskhimfarmpreparata of Semashkorossiya
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Apteka24

  • Prednizolonnizhfarm (Russia, Nizhny Novgorod)
  • Prednizolonkrasny star (Ukraine, Kharkiv)
  • Prednizolondarnitsa (Ukraine, Kiev)
  • Prednisolonum solution for in. 30mg/ml 1 ml of amp. No. 5biofarma (Ukraine, Kiev)
  • Prednisolonum solution for injections 30mg/ml 1 ml of an ampoule No. 3biofarma (Ukraine, Kiev)

Paniapteka

  • Ointment of prednizolonovy 0.5% 10 g
  • Ointment of prednizolonovy 0.5% 10 g
  • Prednisolonum of the tab. of 5 mg No. 40

BIOSPHERE

  • Prednisolonum of 30 mg/ml No. 3 solution for ин.амп.Agio Pharmaceuticals (India)
  • Prednisolonum of 0,5% 10 g ointment in a tuba
  • Prednisolonum of 5 mg No. 60 of table. Biosynthesis (Russia)
  • Prednisolonum of 5 mg No. 100 of the tab. Simpex Pharma (India)
  • Prednisolonum Nikomed of 25 mg/ml No. 3 solution for infection.
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Section: Dermatological
PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Prednisolonum surely consult with the attending physician.