Pregnyl

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The description is actual on 26.10.2014

  • Latin name: Pregnyl
  • ATH code: G03GA01
  • Active ingredient: Human chorionic gonadotrophin (Human ChorionicGonadotropin)
  • Producer: Organon (Netherlands)

Structure

Active agent — a human chorionic gonadotrophin.

Additional components: karmelloza of sodium, sodium hydrophosphate, Mannitolum, sodium dihydrophosphate.

Release form

Pregnyl (Pregnyl) is on sale in ampoules with the lyophilized powder for infusions. They contain in a blister strip packaging. In a set there is a solvent in ampoules. In one box there are three sets.

Pharmacological action

Gonadotropic means.

Pharmacodynamics and pharmacokinetics

Medicine is applied to women as substitute of emission of endogenous luteinizing hormone in the middle of a cycle. This means is appointed when planning pregnancy as an auxiliary method before artificial fertilization on purpose for support of a lyuteinovy phase of a menstrual cycle or for improvement of function of ovaries. For men it is used for the purpose of activation of process of formation of testosterone.

The maximum concentration of active component is reached after administration of drug in 20 hours at women and in 6-16 hours at men. About 80% of a human chorionic gonadotrophin are metabolized in kidneys.

Indications to use

This means has the indications for men and women:

  • for women — induction of an ovulation and superovulation, maintenance of function of a yellow body;
  • for men — a hypogonadism, a puberty delay in case of insufficiency of gonadotropic function of a hypophysis, disturbance of a spermatogenesis, a cryptorchism.

Contraindications

It is impossible to use drug at:

  • hypersensitivity to its components;
  • the tumors connected with sex hormones.

Besides, at boys drug in case of premature puberty is not used, and at women – if generative organs are created with the deviations not compatible to pregnancy, and also at incompatible with pregnancy by a fibrous tumor of a uterus.

With care medicine should be taken if women have a risk of development of thrombosis, and men have a latent or explicit heart failure, arterial hypertension, migraine, problems with work of kidneys, epilepsy. Under supervision of the specialist when using Pregnyl also there have to be boys in prepubertal age to avoid early closing of an epiphysis or puberty. It is necessary to monitor development and growth of a skeleton.

Side effects

Patients of both floors at use of this medicine can have following side reactions:

  • generalized rash;
  • fever;
  • reactions on site introductions: bruises, reddenings, itch, painful feelings, swellings.

At women at purpose of Pregnyl can appear:

  • thromboembolism;
  • hydrothorax;
  • painful feelings in a stomach;
  • nausea;
  • diarrhea;
  • ascites;
  • undesirable hyper stimulation of ovaries;
  • syndrome of hyper stimulation of ovaries;
  • morbidity of mammary glands;
  • increase in ovaries and cysts of ovaries;
  • big cysts of ovaries;
  • weight set.

At men and boys such side effects as were noticed:

  • delay of water and sodium;
  • gynecomastia.

Application instruction of Pregnyl (Way and dosage)

The instruction on Pregnyl 5000 and other forms of production of drug reports that medicine is applied in the form of injections. She also tells how to prick this means to patients: solvent mixes up with lyophilisate, and solution is slowly entered subcutaneously or intramusculary.

Dosages in each case are individual:

  • at a hypogonadism, a delay of puberty and a dyspermia appoint 1000–2000 ME 2–3 times a week;
  • at a cryptorchism to children till 6 flyings enter 500-1000 ME 2-3 times a week, and do to children of more advanced age injections Pregnyl 1500 2-3 times a week. Therapy is expected 6 weeks. If there is a need, it can be repeated;
  • for the purpose of induction of an ovulation after therapy by Humegon 5000-10000 ME medicine once is applied;
  • for the purpose of maintenance of a phase of a yellow body appoint 5000-10000 ME for injections 1–3 times. Medicine is entered within 9 days after an ovulation or a puncture of follicles.

Overdose

It is supposed that the raised doses of drug can cause a syndrome of hyper stimulation of ovaries.

Interaction

Medicinal interaction of this means with other drugs is not studied.

At forums, besides, quite often are interested about such combination as Pregnyl 1500 and the test for pregnancy. Specialists recommend to carry out the test for pregnancy not earlier than in 10 days after the last infusion of this medicine. Some doctors say about what after an ovulation or replanting of an embryo has to pass at all not less than 2 weeks before it is possible to carry out the test. So women should not draw premature conclusions: results can be both false positive, and false-negative.

For receiving reliable data it is necessary to watch the level of a human chorionic gonadotrophin in dynamics. It is the best of all to do it by means of laboratory blood tests.

Terms of sale

Medicine is released in drugstores only according to the recipe.

Storage conditions

Optimum temperature of storage of this means – from 2 to 15 °C. To the place where hold drug, the sunlight should not get. Ampoules should be protected from children.

Period of validity

Drug period of validity – three years. It is impossible to use it after the expiration of this term.

Analogs

Coincidence on the ATH code of the 4th level:

This medicine has the following analogs:

All given analogs have the nuances of use so it is not necessary to use them without appointment of the doctor.

Ovitrel or Pregnyl – what is better?

Many doctors claim that both means are identical and actually a difference between them only in the price. Some patients, however, report that Ovitrel is more convenient to use. Besides, cases when this drug was more effective than the analog are frequent. So there is an opinion that such high price of this drug is completely justified.

About Pregnyl

Responses on Pregnyl 5000 and other forms of this drug meet quite often. As a rule, they are left by women who struggle with infertility. They use medicine for stimulation and regulation of processes of maturing of a follicle.

About Pregnyl do not report about unpleasant feelings and side reactions. Its use is painless. Nevertheless, in each case effect of drug individually.

Unfortunately, it is difficult to find a forum at which after use of Pregnyl men share the opinion. However on short responses it is possible to draw a conclusion that use of medicine takes place quite successfully.

Zdravzona

  • Pregnyl 1500ME lyophilisate for Preeg. solution for ampoule injections No. 3 + solvent No. 3Organon
  • Amp No. 1 pregnyl 5000me.
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Apteka24

  • Pregnilorganon (Netherlands)
  • Pregnilorganon (Netherlands)

Paniapteka

  • Pregnyl of a time. for infection 1500ME of amp. No. 3 Organon
  • Pregnyl of a time. for infection 1500ME of amp. No. 3 Organon
Section: Gynecologic Hormonal
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