Prenesa

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The description is actual on 19.07.2016

  • Latin name: Prenesa
  • ATH code: C09AA04
  • Active ingredient: Perindopril (Perindopril)
  • Producer: KRKA of of. The place (Slovenia) is new

Structure

In 1 tablet of a perindopril – 2 mg, 4 mg or 8 mg and excipients.

Release form

Tablets of 2 mg, 4 mg and 8 mg.

Pharmacological action

Anti-hypertensive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Anti-hypertensive means — inhibitor of an angiotensin-converting enzyme. Active ingredient is pro-medicine which in an organism will be transformed to an active metabolite perindoprilat, reducing activity of an angiotensin-converting enzyme.

Under the influence of this enzyme there is a transformation of angiotensin I into II which possesses vasopressor action. Drug reduces the general peripheric resistance, the ABP reduces, without causing tachycardia. There is a decrease in the diastolic and systolic ABP, the peripheral and renal blood stream improves, elasticity of arteries increases. At long reception the hypertrophy of a left ventricle decreases.

The maximum anti-hypertensive effect of drug is noted in 4 hours and in general 24 hours last. The withdrawal is absent.

Pharmacokinetics

Meal reduces bioavailability of drug a little. Peak of concentration of an active metabolite in plasma in 3-4 hours. Equilibrium concentration are reached in 4 days of reception. It is removed perindoprit also its metabolites kidneys. An elimination half-life — 25 hours. Does not kumulirut in an organism. At an impaired renal function the elimination half-life increases.

Indications to use

Contraindications

  • hypersensitivity to a perindopril;
  • galactosemia;
  • use in pediatrics;
  • stenosis of the aortal / mitral valve;
  • stenosis of renal arteries;
  • pregnancy (II, III trimester).

With care it is appointed at collagenoses, a diabetes mellitus, acute heart failure.

Side effects

Prenesa, application instruction (Way and dosage)

Prenes's pill is taken inside before meal of morning, they should not be crushed.

At arterial hypertension a starting dose of 4 mg a day. If in 2 weeks there is no effect, then the dose is increased, bringing 8 mg to the maximum daily dose. At reception of diuretic means reception of diuretic some days before the beginning of therapy by this drug is cancelled, and then gradually entered into the scheme of treatment. If cancellation of diuretic drugs is impossible, then perindoprit appoint in a smaller dose — 2 mg a day.

At heart failure against reception of digoxin, diuretics and beta adrenoblockers, treatment by Prenesa is begun with 2 mg a day. 14 days later a dose gradually increase. At heart failure the water-salt balance is constantly checked and adjusted.

At an ischemic heart disease a starting dose of 4 mg a day which increases in 14 days.

At cerebrovascular disturbances for prevention of a repeated stroke appoint to a dose 2 mg a day, raise a dose to 4 mg, not earlier, than in 14 days after the had stroke. An initial dose for elderly people — 2 mg a day.

Ko-Prenes's tablets are a combination of a perindopril with a diuretic indopamidy which supplement and strengthen effects of each other and therefore a therapeutic dose less, than at monotherapy by one perindopril. The effect remains within 24 hours. Reception begin with 2 mg / 0,625 mg — 1 tablet a day. If in 2 weeks necessary decrease in the ABP is not noted, a dose increase to 4 mg / 1,25 mg of times a day or a tablet in days.

Overdose

Overdose is shown by disturbances of water-salt balance, arterial hypotension (shock is possible) and a renal failure. Tachycardia/bradycardia, cough, dizziness is sometimes noted. The specific antidote does not exist. At the expressed arterial hypotension chloride, catecholamines enter 0,9% of sodium. At heavy intoxication carry out a hemodialysis.

Interaction

Diuretics, tricyclic antidepressants, antihypertensives and neuroleptics strengthen effect of drug. NPVS reduce its efficiency and increase a risk degree of a renal failure. Estrogen also reduces its efficiency. At use with potassium and kaliysberegayushchy diuretics the risk of a hyperpotassemia increases.

Toxicity of lithium at simultaneous use with Prenesa increases and effects of insulin in this connection the thicket needs to control glucose level amplify. Simultaneous use of drugs of gold leads to nitratopodobny reaction. Alcohol increases risk of orthostatic hypotension.

Terms of sale

It is released without recipe.

Storage conditions

Temperature is up to 30 °C.

Period of validity

2 years.

Analogs

Prestarium, Bee-Prestarium, Perindopril, Perinpress.

About Prenes

APF inhibitors to which Prenes's drug belongs are widely used in clinical practice. These drugs prevent development and progressing of heart failure and reduce mortality of patients with AG. This drug is noted by good tolerance and additional antiatherosclerotic action.

Tablets from Prenes's pressure, unlike other hypotensive drugs, are not contraindicated at asthma, a diabetes mellitus, depressions and atherosclerosis of peripheral vessels. They are well combined with other antihypertensives (β-blockers, diuretics, and antagonists of calcium). And confirmation to it is Ko-Prenes's drug representing a combination with diuretic. About that and other drug positive. However, if at soft hypertensia it is possible to control the ABP small doses of monodrug, then at more severe disease the patient appoint the combined means.

  • "... Drug good, suited me — holds pressure normal, never raised. It is very happy".
  • "… In the first week of reception of 4 mg nothing exchanged, the effect went from second week".
  • "… My pressure tall and still I swell therefore the doctor wrote out Ko-Prenes. Helps me, but it is necessary to drink tablets from pressure constantly — on itself it is checked".

Apteka24

  • Prenesakrka (Slovenia)
  • Prenesa30

Paniapteka

  • Prenesa of the tab. of 4 mg No. 30KPKA
  • Ko-Prenes of the tab. 2mg/0.625mg No. 30KPKA
  • Ko-Prenes of the tab. 2mg/0.625mg No. 30KPKA
  • Ko-Prenes of the tab. 2mg/0.625mg No. 30KPKA
  • Prenesa of the tab. of 4 mg No. 30KPKA
Section: Cardiovascular
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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