Primafungin

Примафунгин Drug photo

The description is actual on 28.07.2016

  • Latin name: Primafungin
  • ATH code: G01AA02
  • Active ingredient: Natamitsin (Natamycin)
  • Producer: LLC FARMAPRIM (Moldova)

Structure

In 1 suppository of a natamitsin of 100 mg. Cetyl alcohol, sorbitan, polysorbate, Natrii hydrocarbonas, adipic acid, semi-synthetic glycerides as excipients.

Release form

Vaginal suppositories No. 3.

Pharmacological action

Antifungal.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active agent belongs to half-yen antibiotics with antifungal fungicidal action. Natamitsin connects fatty acids of cellular membranes of microorganisms, breaks their function and causes death. Drozhzhepodobny mushrooms of Candida albicans, Microsporum, Trichophyton, Epidermophyton, Aspergillus, Fusarium, Penicillium are sensitive to it. It is active concerning protozoa (trichomonad). Suppositories melt, forming the volume foamy weight which evenly distributes active ingredient on mucous vaginas. Resistance to a natamitsin does not meet. Primafungin at pregnancy is resolved on all terms, and also it is possible to apply in the period of a lactation. At use of this drug the vulval biocenosis remains.

Pharmacokinetics

Almost it is not soaked up from a mucosal surface of a vagina and has no systemic action.

Indications to use

  • fungus diseases of a vagina and vulva;
  • prevention of fungal infections at treatment by glucocorticoids, cytostatics, or antibiotics.

Contraindications

Hypersensitivity.

Side effects

  • burning sensation in a vagina;
  • irritation of mucous.

Primafungin, application instruction (Way and dosage)

Candles Primafungin are appointed within 4-6 days. Enter on 1 candle deeply into a vagina, lying on spin, daily for the night. Suppositories cannot be cut on part as it breaks hypodispersion of active ingredient.

In the period of periods treatment needs to be interrupted. During treatment it is necessary to use barrier contraceptives.

Inspection of the sexual partner is recommended and if it is necessary to treat.

Overdose

Cases of overdose are not registered.

Interaction

Interaction was not studied.

Terms of sale

It is released according to the recipe.

Storage conditions

Temperature of storage is 15-20 °C.

Period of validity

2 years.

Primafungin's analogs

Coincidence on the ATH code of the 4th level:

Pimafutsin cream and candles.

About Primafungin

Primafungin — an effective remedy for topical treatment of a candidosis vulvovaginitis, including at pregnant women. Researches showed efficiency that was confirmed by positive dynamics and results of laboratory researches.

However, responses of patients meet different and many are frightened by plentiful allocations together with the leaving candle components. Many consider that treatment does not help. But for the sixth or seventh day improvement was noted: burning and an itch disappeared, allocations from a vagina stopped. At primary candidosis vulvovaginitis drug was appointed in the form of monotherapy within 6 days, and at recuring — a probiotics was in parallel appointed and treatment made 9 days.

  • "… Drug good, suits me, in the first days symptoms remain, and then everything passes for a long time".
  • "… I use them already the third time for pregnancy. Ceases for 2-3 months".
  • "… At pregnancy the safest drug. After the first candle it is already much easier, and after the termination of a course — a smear ideal".
  • "… Used Primafungin — he did not help me, the feeling of an itch all the same did not pass".
  • "… The most effective — relieved of the milkwoman in a week".
  • "… I prefer cheaper Primafungin".

Zdravzona

  • Primafungin No. 3 svechifarmapry
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BIOSPHERE

  • Primafungin of 100 mg No. 3 supp.vag.farmaprim SRL (Moldova)
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Section: Gynecologic Antifungal
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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